I'm currently on 2 grains - due to up my dose to 2.5 next Tuesday. I have noticed that when I increase my dose, I feel better for a while but it tapers off a little after a week or so. Presumably this is just because I'm not on enough yet. I've noticed today that the tiredness is creeping back in, esp this afternoon (despite splitting my doses morn and avo). Would tomorrow be too soon to increase by another half? I haven't had any adverse effects when increasing dosages so far.