The impacts of T3 slowly unfurl like an infinite Swiss roll. Insufficient T3, in the right place, at the right time, will most obviously have impacts and, in this paper, they are seen on the adult brain - in ageing and disease.
The hippocampus is a prime part of the brain involved with memory. Perhaps less than surprising that memory issues are reported so often by thyroid patients.
As so often, the abstract is tantalising.This time, the full paper is also available here:
I have yet to tackle it!
Front Endocrinol (Lausanne). 2014 Apr 28;5:62. eCollection 2014.
Thyroid Hormone Signaling and Adult Neurogenesis in Mammals.
Remaud S, Gothié JD, Morvan-Dubois G, Demeneix BA.
UMR CNRS 7221, Evolution des Régulations Endocriniennes, Département Régulations, Développement et Diversité Moléculaire, Muséum National d'Histoire Naturelle , Paris , France.
The vital roles of thyroid hormone in multiple aspects of perinatal brain development have been known for over a century. In the last decades, the molecular mechanisms underlying effects of thyroid hormone on proliferation, differentiation, migration, synaptogenesis, and myelination in the developing nervous system have been gradually dissected. However, recent data reveal that thyroid signaling influences neuronal development throughout life, from early embryogenesis to the neurogenesis in the adult brain. This review deals with the latter phase and analyses current knowledge on the role of T3, the active form of thyroid hormone, and its receptors in regulating neural stem cell function in the hippocampus and the subventricular zone, the two principal sites harboring neurogenesis in the adult mammalian brain. In particular, we discuss the critical roles of T3 and TRα1 in commitment to a neuronal phenotype, a process that entails the repression of a number of genes notably that encoding the pluripotency factor, Sox2. Furthermore, the question of the relevance of thyroid hormone control of adult neurogenesis is considered in the context of brain aging, cognitive decline, and neurodegenerative disease.
adult neural stem cells, adult neurogenesis, brain functions, physiology, plasticity, thyroid hormones
PMID: 24808891 [PubMed - as supplied by publisher]
Image: Structure of the SOX2 protein. Based on PyMOL rendering of PDB 1gt0. 15 December 2009 Author Emw