Endo called today (Sunday) to give me my latest TSH results, etc. My TSH six weeks earlier had been 5.4, which was my primary reason for seeing an endo, as my internist planned to keep me on the same levo dose for another three months and retest. Well, in the interim my TSH has dropped to 0.1! The endo asked whether I'd changed anything about the timing or circumstances of my taking levo. Since I've been following this community and reading everything I can find online about Hashimoto's/hypothyroidism, I have switched from taking levo at night - often not long after eating or drinking something caloric and/or followed 1-4 hours later by antacids - to taking it in the morning on an empty stomach about an hour before eating breakfast and taking my other meds and supplements. Can that really make such a huge difference in TSH?!? I am on the generic Levothroid, whose dosage supposedly is not as well-controlled as that of the USA gold standard, Synthroid. The endo plans to reduce my dose from 125 mcg to 112 mcg and recheck my TSH in six weeks. At least she won't make me wait three months! I'm still suffering with painful joints, muscles and tendons, brain fog and assorted other symptoms. Can those persist after one's TSH drops so precipitously? Perhaps it takes time for the damage to repair?