Diclofenac Sodium (declophen) is a nonsteroidal anti-inflammatory drug recently categorized as thyroid antagonist.

[escalade]

ejhistology.eg.net/Pdf2010/...

[helvella Administrator Thyroid UK]

Thanks for posting.

A paper from 1980 says something similar about fenclofenac.

ncbi.nlm.nih.gov/pubmed/722...

Rod

[escalade in reply to helvella]

Thanks Rod

[diogenes Remembering in reply to helvella]

Care is needed in extrapolating from rats to humans. In small animals like cats and dogs, diclofenac can be very toxic. I think it is fatal to vultures. Toxicity studies in humans (apart from the danger of stomach bleeds) show it is well tolerated in pharmacological doses - I take it periodically myself. The link between hypothyroidism and the drug easily could be coincidence - elderly people take more drugs against arthritis and have also a higher incidence of thyroid disease - just because they happen together doesn't mean there is a link. Re fenclofenac - this is different - it actually displaces T4 from the transport proteins and suppresses the thyroid thereby, causing insufficient T4 to be made. I got into a row with Reckitts on this one when we first published work in The Lancet in 1980 on an FT4 test using fenclofenac patients and showed the depressive effect. After a while they took it off the market I believe.

[Afaghieh]

Well I am so angry. Two weeks ago had to call 111 had a locked neck. My GP gave me IM Diclofenac to follow by tabs 3 times a day. I specificily asked her Whether it will interfere with my Hasi she said no. Its a good job I only took one tablet daily afterwards. The funny part is that the next day I had a blood test for tsh.

[escalade in reply to Afaghieh]

pulsetoday.co.uk/clinical/t...

European Medicines Agency – new safety advice for diclofenac

[r0dg3r]

wow well I take my thyroxine and diclofenic and a couple of other things first thing every morning on an empty stomach and am feeling fine and doing well I thinnk it's all mind over matter and not what you put intop the body I also do an hour and a half pilates three times a week

[HarryE in reply to r0dg3r]

While I am very glad you are doing well, I think 'mind over matter' is a very simplistic and quite judgemental statement. Everyone is different, but we are united by trying to be as well as we possibly can be

[r0dg3r in reply to HarryE]

pricisly everyone is differant and everyone copes in a differant way with pain etc

[serenfach]

I was given this when I was in hospital and had what I can only describe as a panic attack. I wanted to "get away", but due to all sorts of tubes in and out, could not move. When I asked for help, the nurses said they were too busy. I told the doctor in the morning, but he repeated the dose for me. I refused to take it, and a Sister went to fetch the contra list to allay my fears. There in black and white it said "panic attacks rarely". It is now a warning on my medical notes. It was replaced with Tramadol for over a year (I weaned myself off gradually but still suffered withdrawal symptoms) and then was replaced with Codeine, for over 2 years. This has just been suddenly cut completely from my repeat prescription, and when I queried this, was told "get something from the chemist". Trouble is nothing they sell touches the pain unless I take a packet a day!