I was on 3 grains in the summer and it didn't work for me. I tried one grain and even half a grain and it stillI gave me violent stomach ache. You can ready my previous posts this past year for the different problems I have had. My private specialist was useless and my GP not interested. Prior to NDT I had been on 200mcg Levo and that gave me new symptoms and made my existing ones much worse. I had put on nearly four stone and couldn't shift it despite not having much of an appetite for a long time. I was a mess. I took matters into my own hands as I was at my wits end. I stopped NDT completely and didn't take anything for about two months. Then I ordered T3 without prescription and followed my own instincts and started taking 50mcg a day and increased to 75mcg. I have now lost TWO STONE!! YES TWO STONE! I am feeling much better and at last I am starting to feel as if I am getting me back again. You will get there.