For hyper/subclinical hyper, what would be a recommended low dose of Carbimazole to relieve symptoms?

[londonish]

My TSH is 0.6 (0.3 - 4.2), FT4 is normal 15.1 (12 - 22), lab did not test FT3 but have requested again.

I have lots of clinical symptoms

[Hidden]

What are your symptoms? I can't believe you'd be hyper with a T4 of 15.1. Could be something else like adrenals, B12 etc.

Hampster

[londonish]

Hi Hamster and thanks for replying.

Symptoms are jumpy heart, hair loss, inability to keep still, overheating physically and emotionally, anxiety, eating large amounts to maintain weight, soft stools, prominent neck, other endocrine irregularities over the years, grandmother hypo.

It may be that I am subclinical, but I do feel that something's going on!

[Hidden in reply to londonish]

Have you got copies of all your blood test results? It might be worth posting them if you've had full blood count etc., maybe some clues there. Agree that T3 test would be good. You say you've got a prominent neck, has the doc ever done an ultrasound scan? Also, have they checked for thyroid antibodies?

I would definitely ask the doc to do the vits and mins tests, if they're saying it's not thyroid then it must be something else and they have an obligation to investigate in my mind. So the usual B12, folate, ferritin (iron), vit D, calcium.

[bunny7872]

I had to have betablockers increased to compensate the symptoms as they increased rather than retracted as I came into normal range. Took 6 months before they were lowered and finally stopped after a year along with most symptoms. I still get most in a milder dose including palpitations, red rage, anxiety and weight changes but I now sleep and that helps alot. Wishing you well

[londonish]

Amen to sleeping well! My sleeping is dire but did not list that in symptoms as I'm also menopausal which muddies the waters (though have had hot flushes all life)

My neck is not gross, just not quite like other people's.

My GP is great and has reordered T3, and also antibodies, oestradiol, progesterone, testosterone, sex hormone binding globulin, calcium, Vit D, B12, ferritin, folate and haemoglobin electrophoresis.

He has also referred me to an Endo.

The previous basic bloods were normal except that my cholestrol is high (I do smoke but am slim, active and eat healthily), and my MCV and MCH were near the top of the range.

Thank you again

[greenginger in reply to londonish]

Hi when I was subclinical and before I became hyper with Graves in 2011, I also had higher cholesterol and my MCV and MCH were high ( these can also indicate viral illness btw). Are you in your 40's ?

I agree that betablockers might help. However it is not likely that you will be given carbimazole with those numbers. I know that hypos are sometimes given levo when borderline but I have never heard of anyone being given carb for that reason.

[Hidden in reply to londonish]

High MCV and MCH do generally suggest B12 or folate deficiency, so it's good the docs tested these. As always get copies as low normal is usually a problem.

labtestsonline.org.uk/under...

"Mean corpuscular volume (MCV) is a measurement of the average size of your RBCs. The MCV is elevated when your RBCs are larger than normal (macrocytic), for example in anaemia caused by vitamin B12 deficiency or folic acid deficiency. When the MCV is decreased, your RBCs are smaller than normal (microcytic), which may indicate iron deficiency anaemia, inflammation or occasionally thalassaemias.

Mean corpuscular haemoglobin (MCH) is a calculation of the amount of oxygen-carrying haemoglobin inside your RBCs. Since macrocytic RBCs are larger than either normal or microcytic RBCs, they would also tend to have higher MCH values."

b12deficiency.info

[londonish]

Yes, I had read that about B!2 and iron (here!). Plus I have been craving meat.

I am in my 50s, GG, but have had most of these symptoms most of my life.

Is there a link to high cholestrol, then?

[Hidden in reply to londonish]

Not sure, think high cholesterol is more associated with hypothyroidism? There's a symptom checker here, see how you score:

b12d.org/b12-signs-symptoms...

[londonish]

Thanks for the link