Can you help me please? My 19 year old daughter has chronic hypothyroid symptoms. She was put on Levothyroxine (50mgm) and Liothyronine - at my insistence -(10mcg) 6 weeks ago. Her initial blood tests showed TSH 2.73, FT4 13.6 and FT3 4.82. Her endo agreed to put her on medication for a short time to rest and reset her system - we think she has adrenal fatigue. She started immediately to feel better. After the first month her blood tests showed TSH 0.06, T4 15 and T3 4.84. I was surprised and disappointed her T4 and T3 hadn't improved. Since then she has got steadily worse again, so that now she is just as exhausted as she was prior to going on the medication. Can you tell me whether it is the Levo or the Lio that I need to see whether we can increase? Does the Lio effect the T4 and T3. I can see that her TSH should be low enough now. Initially her endo had been talking about a ratio of Levo to Lio of !:5, but she is on 1:10, so I assume it is Lio we need to try and up? Many thanks for your help.