Taking Amitriptyline with underactive thyroid - Thyroid UK

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Taking Amitriptyline with underactive thyroid

sidneymark70 profile image
25 Replies

Just been prescribed amitriptyline (10mg) at night because of clenching jaw problems while sleeping - pain and bad clicking jaw. I am also on 100mg levothyroxine because of Hashis. Have just read on the leaflet inside that there is a warning with taking this with thyroid disease. My GP knows this of course so am loathe to contact her to ask if its ok because presumably she thinks it is. Does anyone know anything about this please?

(p.s. have been on Sertraline for depression and anxiety and the consultant I saw for the jaw problem thinks this might be causing sleep problems e.g. have the most vivid dreams every night and beginning to wonder which is reality and what I have dreamt!And it is him who has suggested I change to amitriptyline) I now feel really low with the mess that I seem to be in, all because I've been struggling to feel better. Thank you.

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25 Replies
KLR22 profile image
KLR22

I take 10mg Amitriptyline and also am on thyroxine. Don't think there's a probem with taking both. I've never had any problems although I'd like to get off Amitriptyline.

Karen

sidneymark70 profile image
sidneymark70 in reply toKLR22

Thanks Karen. Can I ask why you'd like to get off Amitriptyline please?

KLR22 profile image
KLR22

I've been on it a long time and have slightly raised liver enzymes which I'm unsure is caused by Amitriptyline. I only went on it because I felt so ill as I was undermedicated with thyroxine but find it difficult to come off Amitriptyline because I then can't sleep.

Karen

Karlos profile image
Karlos in reply toKLR22

This is most ineteresting, I was taking amitriptyline and recently also had raised liver enzymes! I have since been for a liver scan and it showed that I have fat on my liver.

What makes you think it's the Amitriptyline that causes this?

Regards

Karl.

Loetitia profile image
Loetitia in reply toKarlos

Because I never had Liver enzymes before I started taking it, so very interesting!

Regards Loetitia

Loetitia profile image
Loetitia in reply toKLR22

\thanks

Karen, same withdrawal symtoms, so any other idea's to make the coming off Amtripyline easier?

Loetitia

klr31 profile image
klr31 in reply toLoetitia

Just cutting it down slowly. I haven't managed this as yet (although did get down to half - 5mg - at one time, but I have had a lot of stress over the past couple of years so need my sleep to feel as okay as possible. I do intend to try again once things settle down. I know I ought to come off it to help myself but sleep is SO important, isn't it. I'm currently on around 12/15 mg.

Karen

lifexperience profile image
lifexperience in reply toKLR22

I had raised liver enzymes when I was on Amitriptyline. Had to see a liver surgeon. But turned out to be the Amtriptyline as they went back to normal after stopping them. Daresay they are raised again as I am back on them.

klr31 profile image
klr31 in reply tolifexperience

Does it damage the liver?

sidneymark70 profile image
sidneymark70

Thank you for that Karen. Hope you feel better than you did, despite the liver problems. Isnt it all a nightmare? You help one part of yourself and damage another. Take care.

shaws profile image
shawsAdministrator

If you cursor down to the l/h side of the page you will see a reference to amytriptyline

web.archive.org/web/2010122...

KLR22 profile image
KLR22

Karlos - Just something I've heard about that Amitriptyline can cause raised liver enzymes; also heart abnormalities when take in high doses for a long time. I had a scan too but it showed nothing untoward.

Sidneymark70 - yes it is a nightmare and doctors don't know much about medications to advise.

Karen

deb25426 profile image
deb25426

I had a terrible jaw clenching problem that was causing be terrible migraines! A trip to the dentist helped, solving it by wearing a bite guard... The dentist actually said that my muscles round my jaw were like a body builders as I'd clenched them that much!!!!!

sidneymark70 profile image
sidneymark70 in reply todeb25426

Pleased to hear you found the answer to your problem, I had been thinking this might be the answer. However I did have a bite guard made by my dentist and now I cant find it! (think my dog might have buried it in my garden along with many other missing items!!) and now I cant afford to have another one made as it was quite expensive.

deb25426 profile image
deb25426 in reply tosidneymark70

It is expensive.Mine was part of treatment £204 for crown, fillings etc.. It was the maximum they could charge for treatment!!!!

bailey72009 profile image
bailey72009

Hello I am new to the forum. But 20 years ago put on Amitriptyline. I found many side effects. I have not taken it since but been put on many antidepressants over the years. Have you tried herbal medication. There is 1 available which I can recommend. Also the shop where it is available also the web site. Never give up there is help out there.

sidneymark70 profile image
sidneymark70 in reply tobailey72009

Would love your recommendation please Bailey please

Sedgie profile image
Sedgie in reply tosidneymark70

And me please 😊

Loetitia profile image
Loetitia

I take both, and have done now for about 18years, Ampitriptyline 100mg and 100mg thyroid however, decided to try to come off Amtriptyline today, so please can anyone help coming off suc a large dose, feel not working any longer, am ob Nitrizipan as well, far too much. Amy help appreciated, thank you

Sedgie profile image
Sedgie in reply toLoetitia

I was on 50mg of amitriptyline having started on 10mg. My dose was for chronic headaches. I built up a tolerance. My dr wanted me off if a year ago. I found it very difficult. I cut down very slowly. I must have taken 2-3 months. Ask for some lower dose pills so you can do this. I also came off all other pain killers too so it was a tricky time.

Your dose is therapeutic for depression, lower doses are used for pain. Perhaps you can speak to your GP to make sure that you have the support you need.

Loetitia profile image
Loetitia

I too have liver Enzymes, so there must be a link? interesting, It really must be Ampriptyline or Thyroxin, anyone else? Thank you

Loetitia

-deni- profile image
-deni-

I was at dr today, I am on 100mg levo and because I have dizziness, headache dry skin etc he was going to prescribe me amitriptyline! I asked if it was ok (always check)! To take with Levo and he said yes it's fine.

Ruthi profile image
Ruthi

I suffered from jaw clenching, in the end it went on day and night. All I was offered was a mouth guard thing, which hardly treated the cause of the problem.

I did loads of internet research and found many references to TMJ being linked to parasites. No joy from the doc, of course. So I bought a herbal parasite cleanse. Nothing obvious happened, a bit of a headache, but the TMJ disappeared!

lifexperience profile image
lifexperience

I am on 125mg Levothyroxine, 20mg Amtripyline. And I suffer from Buxism overnight and clenching my teeth during the day when I am stressed. I have a mouth guard which I bite like mad. I set my tooth off being painful again two days ago. I take Trazodone for depression and I suffer from insomnia. I don't dream very often. I don't think the Amtripyline is effecting the Levothyroxine. I take both before bed.

I have just done a bit of routing around and thought worth posting here for any one in the future who may be interested in the amitriptaline and thyroid hormone question. Apparently amitriptaline prevents the absorption of thyroid hormones. The hormone replacement needs to be taken at a different time of day and the dose of thyroid hormones may need to be increased when someone is taking amitriptaline.

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