Resolor (prucalopride) good or bad?

[Lovemyfamily89]

Does anyone have any experiences with Resolor ( Prucalopride) that they could share with me? I have just been prescribed these for chronic constipation which I've had since birth. I took one 2mg tablet yesterday and within 1 hour they had the desired effect and I had a comfortable bowel movement but unfortunately I also had a horrific headache which felt as though my head was in a vice and I still have the headache over 24 hours after taking the tablet. As wel as the vice type gripp on my head I have pain running up through my shoulders and neck. I didn't get much sleep last night and I feel dithery and really quite ill. I have checked the side effects list and know headaches is the first one listed but I can't work out if all my symptoms are due to the tablet or if I'm mysteriously 'going down' with something else at the same time- I know I cannot take any more 2mg tablets as I cannot get through a working day feeling like this, I haven't left my bed for over 18 hours, but I'm considering cutting the tablets in half to try taking just 1mg next time. Any experiences and thoughts on this would be gratefully received.

[Hidden]

Oh you poor thing. I have never had these tablets but have more IBS C so know what it's like to be constipated. I soak a rounded dessertspoonful of Linseeds in around a 3rd of a mug of water for an hour or longer if needs be and then drink, this works wonders for me for constipation and of course is natural. Quite a few people use ground down Linseeds.

In the meantime I would definitely go back to your GP as I think you are suffering far too much.

Hope you feel better very soon.

[Lovemyfamily89 in reply to Hidden]

Thanks. I tried linseed before but it didn't work for me. I've just recently seen my consultant and this tablet was the last medical option, I have to consider surgery next, if I can't make the tablets work.

[n9ome in reply to Lovemyfamily89]

Hi

I have been on prucalopride/reselor for a few years now as I have slow gut transition and rectocele. When you first take reselor I had a bad headache for about a week but after that it seemed to go so I would stick with it and see how you feel. My constipation is really bad also from a young age, i was under 1 specialist at a hospital and they didnt have a clue what to do with me so put me onto another specialist at another hospital and now i take upto 8 sachets of movicol a day, 4mg reselor at bed time and I also have a quofora toilet system which is like a colonic irrigation kit which I have to do every morning. Try to stick with it even with all these meds I still have trouble with going to the toilet. I was offered surgery but with me being a young woman they said it was upto me as they said it may cure it but could also leave me with an issue of leakage after surgery so I refused it.

[Lovemyfamily89 in reply to n9ome]

Thank you. I have been on prucalopride now for 14 months and I’m fine with it. I take it at night with bisacodyl and it mostly works for me. I had movicol for 12 years but it stopped working for me. Can you tell me how long you have had prucalopride? I’m trying to guess how long I will get success from it, before it stops working too. The colonic irrigation has been ruled out as an option for me & an Illeostomy is being suggested now, but I’m wondering if I can avoid it for a few more years, if the prucalopride will keep working.

[n9ome in reply to Lovemyfamily89]

I've been on prucalopride for about 5years x

[Lovemyfamily89 in reply to n9ome]

Thank you x

[Lovemyfamily89 in reply to n9ome]

Five years is really good- is it still as effective as when you first took it?

[Love_vodka in reply to n9ome]

Hi n9ome

Are you still taking prucalopride?

You sound like you have similar problems to me. Are you in the UK?

[Lovemyfamily89 in reply to Love_vodka]

Hi, yes I’m still taking prucalopride and bisacodyl at night. Mostly it’s still working although I don’t think it is quite as affective as it was originally. Yes, I am in the UK.

[SlowT1]

I’ve been on Prucalopride on and off for about 4 years due to slow transit. It worked really well for me for several months but then my bloating and stomach pain got worse. That said, up until recently it always help me have a bowel movement although it makes me feel depressed and gives me heart palpitations. I’m now trying Dulcolax liquid but getting the dose right is proving problematic x

[Lovemyfamily89 in reply to SlowT1]

Coincidentally, I have been feeling a little low but I have a few family problems ongoing at the moment plus I’m menopausal so I never thought to blame the prucalopride. I’ve never had dulcolax liquid although I believe that’s the same as the tablets I take with my prucalopride (bisacodyl) - it’s a constant juggle, just trying to make my digestive system work, when most people don’t even have to think about theirs but I try to remind myself that there are many people worse off than me. Good luck 👍

[Love_vodka in reply to Lovemyfamily89]

Thanks so much for replying I’ve been using bisacodyl tablets one or two but they are inconsistent, either don’t work at all or I’m on and off the loo all day. Are you on 2mg resolor, it’s working a little, was thinking of trying 4mg?

I’m also menopausal. Hope your family stuff gets resolved xxx

[Lovemyfamily89 in reply to Love_vodka]

I’m on 2mg nightly but when I suggested to my consultant that I increase it he said it would make no difference but I think I might try it, just to see what happens- have you been taking 2mg or 4mg?

[Love_vodka in reply to Lovemyfamily89]

2 mg , I’m just on my first week so should probably give them a bit more time.

Have you tried any different diets? I don’t think it’s the solution but I only feel ok when I don’t eat or have one meal, bloating just awful (which I think is down to taking medication)

Was thinking of trying elimination to see if it makes any difference xx

[Lovemyfamily89 in reply to Love_vodka]

I’ve had my problems since birth so I tried the various diets when I was younger. Nothing made a difference and as I have got older, upper digestion problems stop me altering my diet much. I have to eat very plain food, no herbs, spices and most fruit gives me problems and a lot of veg too nowadays. This part has only happened over the last 13 years though, before that, I could eat most things. I had my gallbladder out but it didn’t help.

[Love_vodka in reply to Lovemyfamily89]

Well let me know if you try the 4mg? I’m going to try upping it in a few weeks if I’m still not getting great results and just keep an eye on my mood.

Thanks for your help, I really appreciate being able to talk to someone and trying to get as much info as possible.

Take care xx

[Lovemyfamily89 in reply to Love_vodka]

I will. I agree, it’s great to find someone to compare results with. Good luck, let me know how you get on xx