Any recommendations for digestive enzyme brands?

I have IBS-D (with gas) and control my symptoms very successfully with the low FODMAP diet. I can also now infrequently eat small quantities of high FODMAPs and would like to to expand on this theme a bit.

On the strength of posts on this site, I thought I might give digestive enzymes a go, but not only are there lots out there, they all seem to have one or more ingredients that I can't tolerate.

Has anybody had any success with a brand that doesn't contain any of the following: sodium benzoate (E211), rice, sweeteners ending in -ol and powdered fruits?

I'd be very grateful for a lead on this.

11 Replies

  • Not sure if this is suitable but worth a look

  • Thanks very much for this info.

    Have just read the ingredients and can't see anything on there that I know will give me problems so I may well give this a try.

  • I saw my GP for the very same problem and was eventualy prescribed Creon 40000. It is a pancreatic enzyme that helps aid the digestion of proteins in particular. There are different strengths available of Creon and I have to take it 3 times a day at the same time as any kind of food but it is worth it. It has helped me gain some lost weight after IBS-D stopped me from being discharged from hospital after having my J-Tube feeding tube resited. Have a word with your GP about it for more information.

  • Thank you so much for this information, I didn't know that enzymes were available on prescription.

    I'm due to see my GP in the next couple of weeks and will ask her about Creon 40000 then.

    I hope you continue to do well.


  • Thank you so much for wishing me well. Remember that there are different strengths of Creon available on prescription. Take my advice and google Creon and you will see everything about it. Good Luck on getting your GP to prescribe it. Creon more or less forces the body to absorb nutrients from whatever you eat so it is important to take 1 capsule immedietaly before eating or during a meal. This is important.

  • I was on the web looking up Creon as soon as I read your answer - I'm always ready to have a go at possible new solutions! It certainly looks the business and if I can talk my GP into prescribing it for me, I'll let you know how I get on.


  • You might find this interesting:


  • I've just finished reading that article with great interest, many thanks once again.

  • Just read the article. Interesting. I have been on Creon 40000 which I take in capsule form 3 times a day with food. I have been on Creon now for 3 1/2 years and though it remains effective I am a bit wary about being on it long term though.

  • Perhaps you could try one of the OTC enzyme products suggested in the article instead. Until I can get to see my GP about Creon, I've ordered Nutrigest (suggested by Therapist above) as a stop-gap as it doesn't contain any of the ingredients I can't tolerate.

  • I have pancreatic inefficiency and have been prescribed Creon 10000. I have been on this for 12 months and when I went to see consultant and told him that I still had bouts of diahorrea. He told me to increase dose from 1 tablet for snack 2 tablets main meal to 3 tablets each meal. I am now back to square one with diahorrea and back off work. Awaiting to see my GP to see if special diet will help me.

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