Experiences with

Xgeva

I’m on faslodex and Verzenio and Xgeva. Help.

Dorf, continued Orgovyx with 90-day shots of Xgeva. (My hemoglobin immediately dropped to 12.) At the thirteenth month on Orgovyx, PSA began a slow rise indicating castrate resistance. We briefly added 250mg Zytiga + 5mg prednisone before starting Eclipse trial (LU-177 I&T) in June 2023.

He is recommending no surgery but a multimodal therapy with androgen deprivation therapy, medication for the bony metastases (Xgeva) and oncolytic treatment. Did not recommend radiation at this time but not sure if that is the direction he is going.

I also asked her to add maybe Zytiga into the mix he is also having zoladex and Xgeva but she says she is waiting for genomic testing results before she adds anything else . is this normal practice or should I be fighting for something else to be added . any info will be much appreciated . thanks

Xgeva is the next step. I get a Dex scan in Dec. I have a great MO and Urologist and I thank God for them and that these treatments are available. God Bless.

He is on 3 monthly zoladex monthly xgeva he takes the steroid they give him dexamethsone (I think it’s called) day before , day of and day after the chemo . They said it shouldn’t be the cause . They said they might put a stent in each kidney to leery the tubes open .?

He said it would consist of androgen deprivation therapy, medication for the bony metastases (Xgeva) and oncolytic treatment.

In 2021 I had cyberknife radiation to new lesions in spinal vertebrae L3 and T9, which knocked the cancer back but also weakened the bone and led to compression fractures, to harden the bone I'm now also getting an Xgeva (bisphospehante) injection every 90 days, along with a ton of calcium every day.

My doctor also recommends Xgeva shots to strengthen my bones. I know not. Everybody responds to docetaxel, but it appears that , about two out of three have a response and maybe one out of three have a good response.

I will take hormone therapy Letrozole and monthly injection Xgeva-no IV and no chemo. Watch thyroid nodules yearly. Doc V. is very aware of kidney function. Only colonoscopy tomorrow. Thanks for your prayers!

My husband is still chemically sensitive to Eligard and he takes Erleada daily plus Xgeva for bone protection. Anyone is welcome to PM me, especially if the diagnosis is new, the panic and waiting is indescribable. We'll probably learn from each other but mostly I wanted to say I am here for you.

drug interaction between the the Xgeva and my cholesterol meds. I'm wondering if it is going to be worth continuing the Xgeva. Any thoughts or comments?

I seem to recall that you shouldn't have an Xgeva shot just before starting Pluvicto. Thoughts? Thanks to all the great contributors on this site. I rely on you more than you know as I enter the last months of my existence.

My Husband John age 58 was diagnosed in July 2021 Dx PSA 122 Gleason score 9 unfortunately it was already out of his prostate and in surrounding areas they put him straight on Erleada + zoladex + xgeva he went aslong quite nicely for about a year then PSA began to rise so they gave him another PSMA

I finished 10 cycles of doxytaxel and got XGEVA several times. The last two it was discontinued because I reported minor oddities in my teeth. These have gotten a little worse. I will be seeing my dentist but not for about a month.

I’ve been on letrozole, Ibrance and Xgeva for a year and it appears it’s not doing its job any longer. I will know more after scans next week. If not, are you on a clinical trial?

1st treatment after mets dx (and only bone mets except a tiny liver spot) was iBrance 75 mg/Faslodex/xgeva for nearly 3 years (liver resolved itself). 2nd treatment line was Lynparza/Xgeva for about a year - then I got multiple liver mets appear (and yes I'm getting the Guardant360 test done within a

70 yo with Stage 4, multiple bone mets, on Orgovyx daily and Xgeva every 3 months. DaVinci in past.

All labs are good….PSA down from 250 to 215, hemoglobin is at 8.5, calcium is slightly lower so his Xgeva be held in the month of June, Alk Phosphates were 500, now down to 215….and they’ll recheck a few days before treatment.

On a previous post I said that I insisted on discontinuing Xgeva (afraid of the osteonecrosis of the jaw it can cause) injection once a month ( I actually only got the first injection) I got some negative feedback here for this.