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PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0
https://clinicaltrials.gov/ct2/show/NCT03655236
https://clinicaltrials.gov/ct2/show/NCT03655236
Farooqji
in
Cure Parkinson's
5 years ago
Allergic reaction to thyroid meds
My daughter has tried np and levo Both gave her itchy,swollen throat which I know is an allergic reaction to something Now the doc wants her to try tirosint Does anyone else have the same reaction to meds Or could it be something different
My daughter has tried np and levo Both gave her itchy,swollen throat which I know is an allergic reaction to something Now the doc wants her to try tirosint Does anyone else have the same reaction to meds Or could it be something different
Itileguy
in
Thyroid UK
5 years ago
cytomel side effects
Anyone experience acid reflux from cytomel ? Been on 5mcg added to Tirosint 50mcg and have had terrible heart burn. It isn't on the list of sides, doc said he hasn't heard of this. Probably due to something else ...
Anyone experience acid reflux from cytomel ? Been on 5mcg added to Tirosint 50mcg and have had terrible heart burn. It isn't on the list of sides, doc said he hasn't heard of this. Probably due to something else ...
abartme
in
Thyroid UK
5 years ago
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Approved Treatments for Triple Negative MBC Patients
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Hashimoto's - med decrease and feeling awful
Hi, I am 35yo female with Hashimoto’s thyroiditis. I got labs done last week and my doc said I'm border line hyper. I think I most definitely am b/c I was STARVING every 45 minutes and eating constantly. I ended up gaining weight and I just wasn’t feeling good about myself. My lab results were: TSH
Hi, I am 35yo female with Hashimoto’s thyroiditis. I got labs done last week and my doc said I'm border line hyper. I think I most definitely am b/c I was STARVING every 45 minutes and eating constantly. I ended up gaining weight and I just wasn’t feeling good about myself. My lab results were: TSH
Fmljkl
in
Thyroid UK
5 years ago
Approved Therapies for Triple Positive (HR+, HER2+) MBC Patients
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
FDA-Approved Treatments for HER2+, Hormone Receptor Negative Patients
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
CRPC & 'Drug Repositioning'
lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users.[2] It costs $163,381 per year for the average patient." [6a] [6b] Pazopanib "(trade name Votrient) is a potent and selective multi-targeted receptor
tyrosine
lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users.[2] It costs $163,381 per year for the average patient." [6a] [6b] Pazopanib "(trade name Votrient) is a potent and selective multi-targeted receptor
tyrosine
pjoshea13
in
Advanced Prostate Cancer
5 years ago
FDA-Approved Treatments for HR+, HER2- Premenopausal Patients
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Fat-soluble B1, for a 25x enhancement at the brain ?
Note: A commercial presentation of L-
Tyrosine
by Country Life makes no mention of vitamin B1: « L-
Tyrosine
is an amino acid that supports the production of brain neurotransmitters dopamine and norepinephrine. Country Life uses vitamin B6 in order to aid in utilization.»
Note: A commercial presentation of L-
Tyrosine
by Country Life makes no mention of vitamin B1: « L-
Tyrosine
is an amino acid that supports the production of brain neurotransmitters dopamine and norepinephrine. Country Life uses vitamin B6 in order to aid in utilization.»
Pa-zzi69
in
Cure Parkinson's
5 years ago
Approved Treatment Options for HR+, HER2- Postmenopausal Women
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Advice on most complete lab tests to do, including possible Vitamin deficiencies, for Hypothyroidism after radiation therapy
Hi to all, I have found various lists of labs to be done, one that seemed comprehensive I couldn't download, and would be thankful if someone could spell it out for me again (my memory is not too good...!) I am currently on Tirosint, since May, and it's proving difficult to manage. (I can give more info
Hi to all, I have found various lists of labs to be done, one that seemed comprehensive I couldn't download, and would be thankful if someone could spell it out for me again (my memory is not too good...!) I am currently on Tirosint, since May, and it's proving difficult to manage. (I can give more info
Koola
in
Thyroid UK
5 years ago
Mucuna 40% -100% LDOPA? B1 regimen - thoughts?
I also experience a ton of nausea which I can combat with 1/4 tsp powdered L-
Tyrosine
and that works great as a precursor. I experience so much gas, belching and sometimes projectile vomit that I’m unsure of what I’m doing wrong.
I also experience a ton of nausea which I can combat with 1/4 tsp powdered L-
Tyrosine
and that works great as a precursor. I experience so much gas, belching and sometimes projectile vomit that I’m unsure of what I’m doing wrong.
MissRita
in
Cure Parkinson's
5 years ago
Tirosint
Can you get tirosint on prescription in the UK?
Can you get tirosint on prescription in the UK?
kingyl
in
Thyroid UK
5 years ago
Transcriptional profiling reveals a potent activity ofanticancer imidazoacridinone C-1311 against prostatecancer cells
Anticancer imidazoarcidinone C-1311 (Symadex™) is a new inhibitor of topisomerase II and receptor
tyrosine
kinase FLT3 that has been tested in phase II studies against metastatic breast cancer.
Anticancer imidazoarcidinone C-1311 (Symadex™) is a new inhibitor of topisomerase II and receptor
tyrosine
kinase FLT3 that has been tested in phase II studies against metastatic breast cancer.
puxi
in
Advanced Prostate Cancer
5 years ago
Tirosint and cytomel over ndt
So I'm not doing well on compound ndt here in Canada, even though my bloods are close to being optimal. I've gained so much weight this past few months it crazy. My naturopath is considering changing my to tirosint and cytomel. Im due to return to the UK at the end of the year and I'm wondering if
So I'm not doing well on compound ndt here in Canada, even though my bloods are close to being optimal. I've gained so much weight this past few months it crazy. My naturopath is considering changing my to tirosint and cytomel. Im due to return to the UK at the end of the year and I'm wondering if
kingyl
in
Thyroid UK
5 years ago
Could you please help me?
Hi, everybody. How bad are these numbers? TSH 6.97 (0.4-4.5), T3 Total 64 (76-181)and T4 free 0.9. (0.8-1.8) Magnesium 2.2 (1.5-2.5) My doctor increased Levo from 100 to 112. I don't feel any better since that change two months ago. I used to have low TSH until the same doctor changed me to Tirosint
Hi, everybody. How bad are these numbers? TSH 6.97 (0.4-4.5), T3 Total 64 (76-181)and T4 free 0.9. (0.8-1.8) Magnesium 2.2 (1.5-2.5) My doctor increased Levo from 100 to 112. I don't feel any better since that change two months ago. I used to have low TSH until the same doctor changed me to Tirosint
Hidden
in
Thyroid UK
5 years ago
Totally confused now....help with understanding endocrinologist please
A week or so ago I posted the following ‘ would be grateful for a little advice following my recent blood tests so that I’m prepared when I return to see the endocrinologist. TSH 0.35 (0.3-3.6) FT3 2.0 (2.2 - 4.2) FT4 0.83 (0.8 -1.7) I am currently on 100mcg levothyroxine (triosint). When I last saw
A week or so ago I posted the following ‘ would be grateful for a little advice following my recent blood tests so that I’m prepared when I return to see the endocrinologist. TSH 0.35 (0.3-3.6) FT3 2.0 (2.2 - 4.2) FT4 0.83 (0.8 -1.7) I am currently on 100mcg levothyroxine (triosint). When I last saw
Aesm
in
Thyroid UK
5 years ago
Thoughts on Tirosint
Hello all! Looking to get any kind of thoughts or feedback in terms of anyone’s experiences using Tirosint. Any information is quite helpful!
Hello all! Looking to get any kind of thoughts or feedback in terms of anyone’s experiences using Tirosint. Any information is quite helpful!
MissRita
in
Thyroid UK
5 years ago
Zanubrutinib-Gazyva Shows Promise for CLL/SLL
June 25, 2019 Zanubrutinib (BGB-3111) is an investigational small molecule inhibitor of Bruton’s
tyrosine
kinase (BTK). Gazyva is a monoclonal antibody designed to bind to CD20, a protein found on the surface of certain types of B cells, including malignant CLL or SLL cells.
June 25, 2019 Zanubrutinib (BGB-3111) is an investigational small molecule inhibitor of Bruton’s
tyrosine
kinase (BTK). Gazyva is a monoclonal antibody designed to bind to CD20, a protein found on the surface of certain types of B cells, including malignant CLL or SLL cells.
Jm954
Administrator
in
CLL Support
5 years ago
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