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Re: Safety of Zytiga & Xtandi
Many will have seen the piece by Mary Clare Fischer in the Malecare newsletter [1]; below is the link to the published paper [2]. "Men with advanced prostate cancer and their use of abiraterone or enzalutamide were identified in a 20% sample of the 2010-2017 national Medicare claims. "The primary composite
Many will have seen the piece by Mary Clare Fischer in the Malecare newsletter [1]; below is the link to the published paper [2]. "Men with advanced prostate cancer and their use of abiraterone or enzalutamide were identified in a 20% sample of the 2010-2017 national Medicare claims. "The primary composite
pjoshea13
in
Advanced Prostate Cancer
2 years ago
New Trial: A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as Monotherapy or in Combination With Pembrolizumab in Adults With MAST
As most here know, Immunotherapies have not so far proven to be especially effective in PCa. Here is info on a new viral agent that, while not targeting PCa specifically, is starting clinical trials focused on [i]"Metastatic or Advanced Solid Tumours (MAST)"[/i]. With 100 participants, it will hopefully
As most here know, Immunotherapies have not so far proven to be especially effective in PCa. Here is info on a new viral agent that, while not targeting PCa specifically, is starting clinical trials focused on [i]"Metastatic or Advanced Solid Tumours (MAST)"[/i]. With 100 participants, it will hopefully
cujoe
in
Fight Prostate Cancer
2 years ago
Phase II/III trial of troriluzole in spinocerebellar ataxia
Melissa Beiner, MD, Biohaven Pharmaceuticals, Inc., New Haven, CT, discusses the findings of a Phase II/III clinical trial (NCT02960893) of troriluzole in patients with spinocerebellar ataxia. Following the demonstration of troriluzole’s ability to attenuate disease progression in a 48-week open-label
Melissa Beiner, MD, Biohaven Pharmaceuticals, Inc., New Haven, CT, discusses the findings of a Phase II/III clinical trial (NCT02960893) of troriluzole in patients with spinocerebellar ataxia. Following the demonstration of troriluzole’s ability to attenuate disease progression in a 48-week open-label
skyasll
in
Ataxia UK
2 years ago
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4D pharma announces FDA clearance of IND application for Live Biotherapeutics MRx0005 and MRx0029 for the treatment of Parkinson’s disease
https://www.4dpharmaplc.com/en/newsroom/press-releases/fda-clearance-ind-mrx0005-and-mrx0029-parkinsons-disease About MRx0005 and MRx0029 MRx0005 and MRx0029 are oral single strain Live Biotherapeutic products in development for the treatment of neurodegenerative conditions such as Parkinson’s disease
https://www.4dpharmaplc.com/en/newsroom/press-releases/fda-clearance-ind-mrx0005-and-mrx0029-parkinsons-disease About MRx0005 and MRx0029 MRx0005 and MRx0029 are oral single strain Live Biotherapeutic products in development for the treatment of neurodegenerative conditions such as Parkinson’s disease
PDWarrior1900
in
Cure Parkinson's
2 years ago
Some Interesting Information - Parkin-mediated Mitophagy
While the clinical trial in the article does not target PD, some interesting facts that may be related to PD. (Inflammation). Will leave to you guys to infer, especially something related Parkin-mediated Mitophagy and how it is affected in PD patients https://www.cell.com/cell-reports-medicine/fulltext
While the clinical trial in the article does not target PD, some interesting facts that may be related to PD. (Inflammation). Will leave to you guys to infer, especially something related Parkin-mediated Mitophagy and how it is affected in PD patients https://www.cell.com/cell-reports-medicine/fulltext
John_morris71
in
Cure Parkinson's
2 years ago
What are your thoughts on breathing techniques vs medication?
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
joshuap001
in
Asthma Community Forum
2 years ago
What are your thoughts on breathing techniques vs medication?
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
joshuap001
in
Lung Conditions Community Forum
2 years ago
Nubequa Failing?
I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
Joey40
in
Advanced Prostate Cancer
2 years ago
Any association between rising PSA and falling T during BCR?
To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
shueswim
in
Advanced Prostate Cancer
2 years ago
MY JOURNEY: COVID, EVUSHELD, PAXLOVID and CLL
I am sorry this is so long. I really wanted to document and share my journey and remind everyone to be very careful, thoughtful and educated. COVID is no joke! I was diagnosed with Chronic Lymphocytic Leukemia (CLL) in July, 2015. Started a clinical trial of Acalabrutinib (Calquence) in July, 2016 at
I am sorry this is so long. I really wanted to document and share my journey and remind everyone to be very careful, thoughtful and educated. COVID is no joke! I was diagnosed with Chronic Lymphocytic Leukemia (CLL) in July, 2015. Started a clinical trial of Acalabrutinib (Calquence) in July, 2016 at
SandiC
in
CLL Support
2 years ago
Preventing Drug Resistance - Thinking Outside The Box - PRINT Phase 2 Study
One of the biggest challenges of PCa treatment is eventual drug resistance. I've been thinking that maybe Oncologists may have their thinking locked in a box. This is understandable as most take a conservative approach probably, recommending what is "tried and true." So to speak. So I was thinking,
One of the biggest challenges of PCa treatment is eventual drug resistance. I've been thinking that maybe Oncologists may have their thinking locked in a box. This is understandable as most take a conservative approach probably, recommending what is "tried and true." So to speak. So I was thinking,
jazj
in
Advanced Prostate Cancer
2 years ago
Clinical Trials: costs passed to the patient?
Good morning to all in the best support group team ever! Anybody out there participating in a clinical trial research study and then getting billed for part of the cost of it??? After your insurance coverage has been claimed and paid to your provider, do any of you then get billed for any remaining
Good morning to all in the best support group team ever! Anybody out there participating in a clinical trial research study and then getting billed for part of the cost of it??? After your insurance coverage has been claimed and paid to your provider, do any of you then get billed for any remaining
pollymacchili
in
SHARE Metastatic Breast Cancer
2 years ago
Is a Clinical Trial Right for You?
Hi, Have you ever considered participating in a clinical trial? Join CLL Society on Monday, May 16 at 11am PT / 2pm ET for our webinar: Is a Clinical Trial Right for You? Dr. Adrian Wiestner from the NIH and RN Kennard from U PENN will detail the benefits and risks of participating in a clinical trial
Hi, Have you ever considered participating in a clinical trial? Join CLL Society on Monday, May 16 at 11am PT / 2pm ET for our webinar: Is a Clinical Trial Right for You? Dr. Adrian Wiestner from the NIH and RN Kennard from U PENN will detail the benefits and risks of participating in a clinical trial
bkoffman
CLL CURE Hero
in
CLL Support
2 years ago
Mixed news for flavonoids.
New meta-analysis below [1]. The flavonoid family (Anthocyanidins, Anthoxanthins, Flavanones, Flavanonols, Flavans, & Isoflavonoids) include members that have hormone-like properties. "This meta-analysis was aimed to explore the association between flavonoids intake and {hormone-related cancer} HRC
New meta-analysis below [1]. The flavonoid family (Anthocyanidins, Anthoxanthins, Flavanones, Flavanonols, Flavans, & Isoflavonoids) include members that have hormone-like properties. "This meta-analysis was aimed to explore the association between flavonoids intake and {hormone-related cancer} HRC
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Fight Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Advanced Prostate Cancer
2 years ago
We have reached castrate resistance...what to do next?
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
Bmvg02
in
Advanced Prostate Cancer
2 years ago
Rank Neutraceuticals / Off-Label Drugs By Most Likely Most Beneficial
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
jazj
in
Advanced Prostate Cancer
2 years ago
From S of PD. Could all the benefit of B1 be the placebo affect? I think it's time for me to switch to benfotiamine instead.
"So it doesn’t look like there is a strong association between low thiamine levels and PD." "The (Costantini) researchers proposed that “the motor and non-motor symptoms of PD could derive from a chronic thiamine deficiency” in specific regions of the brain. And by increasing in thiamine levels in these
"So it doesn’t look like there is a strong association between low thiamine levels and PD." "The (Costantini) researchers proposed that “the motor and non-motor symptoms of PD could derive from a chronic thiamine deficiency” in specific regions of the brain. And by increasing in thiamine levels in these
MBAnderson
in
Cure Parkinson's
2 years ago
A phase 3 clinical trial found ultra-high dose methylcobalamin slowed functional decline in patients with early-stage ALS
A phase 3 clinical trial found ultra-high dose methylcobalamin slowed functional decline in patients with early-stage amyotrophic lateral sclerosis. https://ja.ma/3L1hd6C
Question
Does twice-weekly intramuscular injection of 50-mg ultrahigh-dose methylcobalamin slow clinical progression in
A phase 3 clinical trial found ultra-high dose methylcobalamin slowed functional decline in patients with early-stage amyotrophic lateral sclerosis. https://ja.ma/3L1hd6C
Question
Does twice-weekly intramuscular injection of 50-mg ultrahigh-dose methylcobalamin slow clinical progression in
Hidden
in
Cure Parkinson's
2 years ago
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