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Sirolimus
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HV88 Virus
Thankfully copies are low and now on 1mg of
Sirolimus
to keep copies low Taking 0.5 Advagraf now as LFT's are still excellent and all well within range and the reduction has helped renal numbers dramatically. Anyone living with the HV88 virus?
Thankfully copies are low and now on 1mg of
Sirolimus
to keep copies low Taking 0.5 Advagraf now as LFT's are still excellent and all well within range and the reduction has helped renal numbers dramatically. Anyone living with the HV88 virus?
Geordiemac
in
British Liver Trust
2 years ago
Considering Rapamycin
Rapamycin (aka
Sirolimus
) is a very interesting drug of diverse effects. It is being explored in early trials for PC because of positive effects demonstrated in cell cultures of PC cell lines and in animal model (mice).
Rapamycin (aka
Sirolimus
) is a very interesting drug of diverse effects. It is being explored in early trials for PC because of positive effects demonstrated in cell cultures of PC cell lines and in animal model (mice).
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Neuroprotective effect of rapamycin against Parkinson's disease in mice - 2018 https://pubmed.ncbi.nlm.nih.gov/30693687/
Conclusions: Rapamycin inhibits the activation of mTOR pathway, which contributes to protect against the loss of dopaminergic neurons and provide behavioral improvements in mice with Parkinson's disease. These results are partially related to the ability of rapamycin in inducing autophagy and reducing
Conclusions: Rapamycin inhibits the activation of mTOR pathway, which contributes to protect against the loss of dopaminergic neurons and provide behavioral improvements in mice with Parkinson's disease. These results are partially related to the ability of rapamycin in inducing autophagy and reducing
Bolt_Upright
in
Cure Parkinson's
3 years ago
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Immunosuppressed Patients Respond to Booster Shots: Hope for a COVID Booster Vaccine for Lupus and Other Autoimmune Disease Patients? [Updat
Immunosuppressed Patients Respond to Booster Shots: Hope for a COVID Booster Vaccine for Lupus and Other Autoimmune Disease Patients? [Updated 8/12/21] August 11, 2021 TABLE OF CONTENTS 1) Will a COVID Booster Vaccine for Lupus Patients Increase Response Rates? 2) The COVID Booster Vaccine Study
Immunosuppressed Patients Respond to Booster Shots: Hope for a COVID Booster Vaccine for Lupus and Other Autoimmune Disease Patients? [Updated 8/12/21] August 11, 2021 TABLE OF CONTENTS 1) Will a COVID Booster Vaccine for Lupus Patients Increase Response Rates? 2) The COVID Booster Vaccine Study
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
3 years ago
The Dirty Drug and the Ice Cream Tub
Radiolab did an amazing piece on rapamycin: https://www.wnycstudios.org/podcasts/radiolab/articles/dirty-drug-and-ice-cream-tub "This episode, a tale of a wonder drug that will make you wonder about way more than just drugs. Doctor-reporter Avir Mitra follows the epic and fantastical journey of a
Radiolab did an amazing piece on rapamycin: https://www.wnycstudios.org/podcasts/radiolab/articles/dirty-drug-and-ice-cream-tub "This episode, a tale of a wonder drug that will make you wonder about way more than just drugs. Doctor-reporter Avir Mitra follows the epic and fantastical journey of a
Rhyothemis
in
Cure Parkinson's
3 years ago
Is anyone using Rapamycin for Parkinson's?
I am interested because of its' ability to stimulate autophagy in the mitochondria. https://www.lifeextension.com/magazine/2021/3/reduce-damaged-cells
I am interested because of its' ability to stimulate autophagy in the mitochondria. https://www.lifeextension.com/magazine/2021/3/reduce-damaged-cells
dick1van
in
Cure Parkinson's
3 years ago
Penn Researchers Identify Specific Genes and Cell Pathways as Key Players in the Rare Female Lung Disease Lymphangioleiomyomatosis (LAM)
Sirolimus
(rapamycin) is the first, and only, treatment approved by the FDA for the treatment of LAM. However, this drug is not effective or well tolerated by some LAM patients, and declining lung function has been shown to continue after treatment.
Sirolimus
(rapamycin) is the first, and only, treatment approved by the FDA for the treatment of LAM. However, this drug is not effective or well tolerated by some LAM patients, and declining lung function has been shown to continue after treatment.
2greys
in
Lung Conditions Community Forum
3 years ago
THE LETTER
All patients on the following medications have been centrally identified and will be contacted via the letter: • Azathioprine • Mycophenolate (both types) • Cyclosporin •
Sirolimus
• Tacrolimus [UNQUOTE] Hope this helps..
All patients on the following medications have been centrally identified and will be contacted via the letter: • Azathioprine • Mycophenolate (both types) • Cyclosporin •
Sirolimus
• Tacrolimus [UNQUOTE] Hope this helps..
Ern007
in
NRAS
4 years ago
Trial IPT Drug rapamycin
Trial IPT Drug https://www.pdsa.org/products-a-publications/e-news/2018-enews/item/1613-pdsa-enews-032818.html Rapamycin is an interesting drug. First, in trials as a cure for (I think) athletes' foot, it was never marketed for that because it was a powerful immune suppressor. It became the "go to
Trial IPT Drug https://www.pdsa.org/products-a-publications/e-news/2018-enews/item/1613-pdsa-enews-032818.html Rapamycin is an interesting drug. First, in trials as a cure for (I think) athletes' foot, it was never marketed for that because it was a powerful immune suppressor. It became the "go to
SurferDude
in
ITP Support Association
4 years ago
Survival With Sirolimus Plus Tacrolimus Maintenance Without Induction Therapy Compared With Standard Immunosuppression After Lung Transplant
Findings In this cohort study of US recipients of lung transplants,
sirolimus
plus tacrolimus was associated with significantly better conditional survival from 1 year after transplant compared with mycophenolate mofetil plus tacrolimus (median survival, 8.9 vs 7.1 years after transplant).
Findings In this cohort study of US recipients of lung transplants,
sirolimus
plus tacrolimus was associated with significantly better conditional survival from 1 year after transplant compared with mycophenolate mofetil plus tacrolimus (median survival, 8.9 vs 7.1 years after transplant).
2greys
in
Lung Conditions Community Forum
5 years ago
SM-88 Report; #2 of 2 from Tyme
Patients also received oral doses of methoxsalen (10 mg), phenytoin (50 mg), and
sirolimus
(0.5 mg) once per day. Most patients had previously received ADT after radiation therapy or surgery, but ADT treatment was not permitted during the trial.
Patients also received oral doses of methoxsalen (10 mg), phenytoin (50 mg), and
sirolimus
(0.5 mg) once per day. Most patients had previously received ADT after radiation therapy or surgery, but ADT treatment was not permitted during the trial.
mistersafety
in
Advanced Prostate Cancer
5 years ago
Use of Rx drugs and botanical compounds to prevent chemo drug-resistance with Docetaxel.
Docetaxel is a common therapuetic used in advanced prostate cancers. There are some combinations you can ask your doctor about that will definitely and safely maximize its effects. Obviously we all all heard of radiation resistance but there is also such a thing as chemo drug-resistance. Countless research
Docetaxel is a common therapuetic used in advanced prostate cancers. There are some combinations you can ask your doctor about that will definitely and safely maximize its effects. Obviously we all all heard of radiation resistance but there is also such a thing as chemo drug-resistance. Countless research
chillpill7
in
Advanced Prostate Cancer
5 years ago
Sirolimus
Hi, I’m almost 6 months post transplant and my creatinine is around 2.2 and my doctors want me to go on
sirolimus
and stop my cellcept. I wanted to know is anyone taking
sirolimus
and have you had side effects?
Hi, I’m almost 6 months post transplant and my creatinine is around 2.2 and my doctors want me to go on
sirolimus
and stop my cellcept. I wanted to know is anyone taking
sirolimus
and have you had side effects?
Curvychic_76
in
Kidney Transplant
5 years ago
Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy
Recently, my doctor is using rapamycin test on ald children patients. The test is from this literature, but the literature was published in 2015. Is there any similar test conducted in other places? https://link.springer.com/article/10.1007/s00401-014-1378-8
Recently, my doctor is using rapamycin test on ald children patients. The test is from this literature, but the literature was published in 2015. Is there any similar test conducted in other places? https://link.springer.com/article/10.1007/s00401-014-1378-8
jayxie
in
Cure Parkinson's
5 years ago
Gou Teng helps with my tremors .
Hi everyone came across Gou Teng and have been trying for the last 3months. I find it does help with my tremor and energy. Thought I’d post and see what you think, I had never heard of it . Wishing everyone the best 🙂 Can you tell me about the Chinese herb gou teng, which I understand is helpful
Hi everyone came across Gou Teng and have been trying for the last 3months. I find it does help with my tremor and energy. Thought I’d post and see what you think, I had never heard of it . Wishing everyone the best 🙂 Can you tell me about the Chinese herb gou teng, which I understand is helpful
twotutts42
in
Cure Parkinson's
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
Good article that provides an update - LOTS going on!! Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resistant Prostate Cancer Bryden Considine, DODaniel P. Petrylak, MD March 13, 2019 Volume: 33Issue: 3 Prostate
Good article that provides an update - LOTS going on!! Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resistant Prostate Cancer Bryden Considine, DODaniel P. Petrylak, MD March 13, 2019 Volume: 33Issue: 3 Prostate
JLS1
in
Advanced Prostate Cancer
5 years ago
Sirolimus
Has anyone been on
sirolimus
or is on it? Leeds are talking about putting me on this as my kidneys are not getting any better on advagraf, but I have heard a few bad things about this medication
Has anyone been on
sirolimus
or is on it? Leeds are talking about putting me on this as my kidneys are not getting any better on advagraf, but I have heard a few bad things about this medication
jojokarak
in
British Liver Trust
5 years ago
A Secondary Analysis of the Exenatide-PD Trial
In this seconday analysis of a randomized clinical trial, serum samples from 60 participants in the Exenatide-PD trial were used to isolate neuronal-derived exosomes to evaluate levels of the brain insulin-signaling proteins and downstream effectors protein kinase B (Akt) and mechanistic target of rapamycin
In this seconday analysis of a randomized clinical trial, serum samples from 60 participants in the Exenatide-PD trial were used to isolate neuronal-derived exosomes to evaluate levels of the brain insulin-signaling proteins and downstream effectors protein kinase B (Akt) and mechanistic target of rapamycin
Farooqji
in
Cure Parkinson's
5 years ago
Chronic gvhd and treatments
Hi ,is anybody taking
sirolimus
for chronic gvhd. Been on few months now seems to be slowing it down. Second attempt on this been on a few treatments but had different side effects which didn't help
Hi ,is anybody taking
sirolimus
for chronic gvhd. Been on few months now seems to be slowing it down. Second attempt on this been on a few treatments but had different side effects which didn't help
jontee
in
Scleroderma & Raynaud's UK (SRUK)
5 years ago
Aspirin & radiation.
New study. -Patrick https://www.ncbi.nlm.nih.gov/pubmed/30609074 Prostate. 2019 Jan 4. doi: 10.1002/pros.23755. [Epub ahead of print] Salicylate enhances the response of prostate cancer to radiotherapy. Broadfield LA1, Marcinko K1, Tsakiridis E1,2, Zacharidis PG1,2, Villani L1, Lally JSV1, Menjolian
New study. -Patrick https://www.ncbi.nlm.nih.gov/pubmed/30609074 Prostate. 2019 Jan 4. doi: 10.1002/pros.23755. [Epub ahead of print] Salicylate enhances the response of prostate cancer to radiotherapy. Broadfield LA1, Marcinko K1, Tsakiridis E1,2, Zacharidis PG1,2, Villani L1, Lally JSV1, Menjolian
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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