Experiences with

Perampanel

I heard Dr Berkowski speak about mainstream treatments (gabapentinoids, iron, opioids in particular buprenorphine) as well as the Nidra device, dipyridamole, ecopicam and perampanel. Was there anything else?

Has anyone had any experience with this drug? Especially after coming off DAs.

He points out that there are limited medications available to treat RLS, but does mention dipyradimole, perampanel and Ganoderma Lucidum mushrooms. He also mentions Tramadol, but not the other low dose opioids set out in the Mayo Algorithm.

Source: https://www.youtube.com/watch?v=L6CtKeOAzGE BUT the likelihood of patients to respond to these treatments is lower if treated for 5+ years with dopaminergics. The reason being the upregulation of D1 receptor responsible for sensitivity to pain and abnormal sensations.

Several anticonvulsant and anti-seizure drugs, including perampanel, lamotrigine, and gabapentin, target glutamate receptors. And at least one small study has shown perampanel prescribed off-label can improve RLS symptoms.

I've been to see Prof Walker who has prescribed me Clonazepam, if that doesn't work he wants me to try Targinact (Oxy) or Perampanel. I'd love to hear back from y'all with your experiences with these medications (positive or negative).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983500/ Keywords: clonidine, dipyridamole, perampanel, amantadine, ketamine, carbamazepine, oxcarbazepine, lamotrigine, topiramate, valproic acid, levetiracetam, steroids, cannabis, bupropion

Perampanel and dypiridamole showed promising but still insufficient data. The same applies to iron supplementation. CONCLUSIONS:Dopaminergic agents are the most powerful suppressors of PLMS.

My neurologist has recently added on perampanel at 2mg to start for 4 weeks then a gradual increase to 4mg to take in the evening.

I have been on Fycompa [Perampanel] for juvenile myoclonic epilepsy since Christmas 2016, my testosterone levels are at an all time high, it affects my sleeping in that it makes me very hyper active my concentration and sleeping patterns are practically non-existent, does anybody else have a similar

13 July, 2015 The epilepsy drug perampanel has been launched across the UK for the treatment of primary generalised tonic-clonic seizures. Will it revolutionise seizure control for thousands of people? https://www.epilepsy.org.uk/news/news/epilepsy-drug-fycompa-launched-nhs-across-uk-64849