Has anyone had any experience with this drug? Especially after coming off DAs.
perampanel: Has anyone had any... - Restless Legs Syn...
perampanel
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sigurdur
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It may actually help RLS.
My doctor gave me 3 prescriptions to try and perampanel is one of them. I will get it filled and report back.
what were the other 2?
They were numbered.
#1 Gabapentin. I have been trying Gabapentin, up to 600mg, had previously tried Pregabalin and hated it. Gabapentin agrees with me more than Pregabalin, but I still really don't like it and I would hate to have to increase the dosage as already don't feel 100% when taking it. There is also no lack of Gabapentin horror stories.
#2 Perampanel.
#3 Targin. I don't know why he prescribed targin as I can't get that prescription filled without a blessing from the Spanish king. I live in Spain.
As I said the Perampanel "may" help but it will not control it like gabapentin will. Did you give it at least a month for the side effects to go away or lessen? I take it and have no problems on it.
Another one to try is dipyridamole. You might want to discuss this with your doctor. It has helped some people on this forum and another forum I am on and has completely eliminated RLS in some. In the winter 2022 edition of Night Walkers, the publication of RLS.org there is an article by Sergi Ferre about dipyridamole discussing the effectiveness of it in a 2 week double blind placebo controlled study showing it completely ameliorated all symptoms. The study was by Dr. Garcia Borreguero movementdisorders.onlinelib... sciencedirect.com/science/a...
Take it on an empty stomach. (fats inhibit absorption) about 1-1/2 to 2 hours before bed. If you have headaches they tend to disappear or lessen after around 5 days.
No to be honest I haven't taken gabapentin frequently for a full month. And I increased the dose too fast, which made me feel really strange. I did try dipyridamole, but it didn't work for me, and as I understand it rarely does for those who have messed up their dopamine system with DAs. Perampanel is also from a study done by the same people. My sleep doctor is friends with Dr. Garcia Borreguero.
My laugh for the day - "without a blessing from the Spanish king" 😀😀😀
However I know a doctor in Spain that will prescribe buprenorphine and the pharmacy fills it so why not call your pharmacy and ask. I don't think he would have prescribed it if she didn't think it could be filled.
My pharmacy refused to fill it. Which is OK, there were the other 2 to try first. I am also reluctant to try opioids as I have a history of substance abuse.
Understood. Then lets hope the Perampanel works well for you.🤞
There is one study by a Spanish group headed by prof Diego Garcia-Borrguero, that trialled perampanel for RLS. pubmed.ncbi.nlm.nih.gov/285... Somewhat positive, but not overwhelmingly, according to my memory.
That group also trialled dipyridamole. pubmed.ncbi.nlm.nih.gov/341...
Hope the perampanel works for you.
Dipyridamole (trademarked as Persantine and others) is a nucleoside transport inhibitor and a PDE3 inhibitor medication that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.
Highly unlikely to mitigate RLS symptoms in any. way.
It has other properties as well. There is a difficult to read and lengthy research paper by Sergi Ferre and coworkers from a few years ago. About adenosine and its role in the dopamine transport/signalling system. Dipyridamole is also an ENT1/2 blocker if I remember correctly, and through that role influences the adenosine-dopamine connection. Something like that. I am tired and it has been a few years since this study and that I read it. Bit long story short, there is good scientific backup for the potential of dipyridamole to affect (positively) RLS.
The drug label has a black box warning that the drug may cause serious psychiatric and behavioral changes; it may cause homicidal or suicidal thoughts. Other side effects have included dizziness, somnolence, vertigo, aggression, anger, loss of coordination, blurred vision, irritability, and slurred speech. Perampanel reduced the effectiveness of levonorgestrel oral contraceptives by about 40%. Women who may get pregnant should not take it as studies in animals show it may harm a fetus.[12] Perampanel is liable to be abused; very high doses produced euphoria responses similar to ketamine. It is designated as a Schedule III controlled substance by the Drug Enforcement Administration.
As of August 2016 perampanel had been studied and development discontinued in migraine, multiple sclerosis, neuropathic pain, and Parkinson's disease.
Beware of these non-standard drugs, especially outside the USA.
