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What treatment next as PSA increasing on Daroludamide & Lupron
My PSA is increasing after a year on Daroludamide and Lupron.
Questions:
1) can the Daroludamide be increased?
2) what is the next treatment after this to reduce PSA?
Sincere thanks.
My PSA is increasing after a year on Daroludamide and Lupron.
Questions:
1) can the Daroludamide be increased?
2) what is the next treatment after this to reduce PSA?
Sincere thanks.
mklc
in
Advanced Prostate Cancer
3 months ago
Researchers discover new cellular mechanisms in Parkinson’s disease (technical)
“Our studies show that multiple pathways are perturbed in the disease and so we think that rescuing multiple pathways at once is essential for disease modification.” “We’re not saying that [alpha-synuclein aggregation] is not important, but we’re showing that there are other proteins and RNA inclusions
“Our studies show that multiple pathways are perturbed in the disease and so we think that rescuing multiple pathways at once is essential for disease modification.” “We’re not saying that [alpha-synuclein aggregation] is not important, but we’re showing that there are other proteins and RNA inclusions
jeffreyn
in
Cure Parkinson's
3 months ago
recent cirrhosis diagnosis scared
Hi I’m new to this so not sure I can post this here , yesterday I received bad news about my liver , having cirrhosis NAFL metabolic dysfunction related liver disease I haven’t been given a prognosis however I am so scared , I am an alcoholic and morbidly obese , I have been given guidance ( brief
Hi I’m new to this so not sure I can post this here , yesterday I received bad news about my liver , having cirrhosis NAFL metabolic dysfunction related liver disease I haven’t been given a prognosis however I am so scared , I am an alcoholic and morbidly obese , I have been given guidance ( brief
Charlotteb1991
in
British Liver Trust
3 months ago
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Sacituzumab govitecan, an anti-Trop-2 antibody-drug conjugate, for treating cerebral metastasized castration-resistant prostate cancer.
Improved survival rates have been observed in castration-resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorable prognosis. Therefore, there is an urgent need to explore new therapeutic
Improved survival rates have been observed in castration-resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorable prognosis. Therefore, there is an urgent need to explore new therapeutic
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
What a difference a year makes!
This is probably a post for those who are fairly new to the site, I still consider myself one of those people. This isn’t a post about reversing cirrhosis. Or some miracle I’ve experienced. It’s purely to provide my experience, the questions I had at the start, the complete hopeless feelings I experienced
This is probably a post for those who are fairly new to the site, I still consider myself one of those people. This isn’t a post about reversing cirrhosis. Or some miracle I’ve experienced. It’s purely to provide my experience, the questions I had at the start, the complete hopeless feelings I experienced
DaveQ67
in
British Liver Trust
3 months ago
Good news from Korea - Stem cell-based therapy being developed by S.Biomedics
TED-A9 is an investigational therapy consisting of dopaminergic neuron precursors derived from human embryonic stem cells. These precursors are generated in a laboratory and have the potential to differentiate into various cell types under appropriate conditions. The therapy is surgically implanted
TED-A9 is an investigational therapy consisting of dopaminergic neuron precursors derived from human embryonic stem cells. These precursors are generated in a laboratory and have the potential to differentiate into various cell types under appropriate conditions. The therapy is surgically implanted
Farooqji
in
Cure Parkinson's
3 months ago
Slight PSA rise and MO discontinuing ADT due to fatigue
Father, 86, Stage 4A prostate cancer has been treated under STAMPEDE Protocol since November 2022 including prostate + whole pelvic radiation completed March 2023 (history in bio). Had appointment with MO today - initial plan was for this to be last shot of Lupron while Zytiga would be continued for
Father, 86, Stage 4A prostate cancer has been treated under STAMPEDE Protocol since November 2022 including prostate + whole pelvic radiation completed March 2023 (history in bio). Had appointment with MO today - initial plan was for this to be last shot of Lupron while Zytiga would be continued for
Superbfloor
in
Advanced Prostate Cancer
3 months ago
heparin innohep Uk
hi all, I’m in the U.K. I don’t have a specialist just GP and a nurse anticoagulant clinic I visit. Are U.K. APS patients on warfarin suppose to have a heparin injections supply at home for emergencies when inr too low. The nurse said it’s a good idea since pharmacies don’t usually have in in stock
hi all, I’m in the U.K. I don’t have a specialist just GP and a nurse anticoagulant clinic I visit. Are U.K. APS patients on warfarin suppose to have a heparin injections supply at home for emergencies when inr too low. The nurse said it’s a good idea since pharmacies don’t usually have in in stock
Kev667
in
Hughes Syndrome APS Forum
1 year ago
looking for input - RIsing PSA with Negative PSMA Pet scan
diagnosed in 2020 with Oligometastatic prostate cancer (1 spot detected on right ischium (hip)). Had prostate removed via surgery, did 39 radiation treatments to hip and prostate bed and took Lupron and Erleada . Stopped the hormone therapy in July 2022 (psa undetectable for 2 yrs). My psa in 2024
diagnosed in 2020 with Oligometastatic prostate cancer (1 spot detected on right ischium (hip)). Had prostate removed via surgery, did 39 radiation treatments to hip and prostate bed and took Lupron and Erleada . Stopped the hormone therapy in July 2022 (psa undetectable for 2 yrs). My psa in 2024
ND1988
in
Advanced Prostate Cancer
3 months ago
LVV Relapse Update
Good news … after 2 weeks at 25mgs pred, my markers are back to “normal”, ie CRP at 2 and ESR is 8. I have had two TCZ jabs a week apart, so could this have already created the masking effect, which had waned with the 4 weekly jabs? Now to begin the taper: 20mgs for 2 weeks and then 17.5 x 2 etc.
Good news … after 2 weeks at 25mgs pred, my markers are back to “normal”, ie CRP at 2 and ESR is 8. I have had two TCZ jabs a week apart, so could this have already created the masking effect, which had waned with the 4 weekly jabs? Now to begin the taper: 20mgs for 2 weeks and then 17.5 x 2 etc.
LemonZest11
in
PMRGCAuk
3 months ago
Borderline/low cortisol child
Hello lovely people, I posted last week about my 9 year old daughter being diagnosed with autoimmune hypothyroidism. I received some great support from this community and wonder whether you could perhaps offer me some further wisdom please. It transpires that she also has a cortisol level that is just
Hello lovely people, I posted last week about my 9 year old daughter being diagnosed with autoimmune hypothyroidism. I received some great support from this community and wonder whether you could perhaps offer me some further wisdom please. It transpires that she also has a cortisol level that is just
figster
in
Thyroid UK
3 months ago
Minor change in psa - reason to be concern?
Hi, My dad just got an update on his PSA #. 3 weeks ago his PSA was 0.37, our family went on vacation, and he just got back and had his blood work done again. All enzymes normal, but PSA ticked up slightly to 0.47. Is this concerning at all? I thought PSA was suppose to trend to undetectable levels
Hi, My dad just got an update on his PSA #. 3 weeks ago his PSA was 0.37, our family went on vacation, and he just got back and had his blood work done again. All enzymes normal, but PSA ticked up slightly to 0.47. Is this concerning at all? I thought PSA was suppose to trend to undetectable levels
Cafu6
in
Advanced Prostate Cancer
3 months ago
in remission and stable
I have AIH/PBC and Barrett’s oesophagus I have been in remission for about 18months , interested to hear how long anyone else has stayed in remission? I am still on 3mg budesonide, mycophenolate and urso and numerous other tablets, unfortunately I am getting a lot of IBS does anyone else suffer with
I have AIH/PBC and Barrett’s oesophagus I have been in remission for about 18months , interested to hear how long anyone else has stayed in remission? I am still on 3mg budesonide, mycophenolate and urso and numerous other tablets, unfortunately I am getting a lot of IBS does anyone else suffer with
Suecong
in
British Liver Trust
3 months ago
Finally found some relief for IC
Hi everyone, I’m 48 & was diagnosed with IC & Hunners ulcers after having a bladder lift in 2005 & having the mesh fall apart & get stuck in my pelvic floor wall. The mesh was of course toxic and did a number on my bladder as well. I tried EVERYTHING you could imagine & kept track of when pain would
Hi everyone, I’m 48 & was diagnosed with IC & Hunners ulcers after having a bladder lift in 2005 & having the mesh fall apart & get stuck in my pelvic floor wall. The mesh was of course toxic and did a number on my bladder as well. I tried EVERYTHING you could imagine & kept track of when pain would
Ali_rivers
in
Pelvic Pain Support Network
3 months ago
Continued Journey
Day +14: I am presently unhooked from my medication pole. It is a great feeling to be able to be more mobile around my “suite”. Accommodations here quite nice considering what most hospital rooms are like. it has been a rough go with a certain amount of nausea, lack of energy, and G.I. situations
Day +14: I am presently unhooked from my medication pole. It is a great feeling to be able to be more mobile around my “suite”. Accommodations here quite nice considering what most hospital rooms are like. it has been a rough go with a certain amount of nausea, lack of energy, and G.I. situations
FiArt12X
in
CLL Support
3 months ago
Subcutaneous combination therapy improves ‘good on’ time in Parkinson’s
Primary analyses from this phase 3 clinical trial of the investigational, subcutaneous infusion of levodopa/carbidopa (LD/CD) (ND0612) showed that treatment in doses of up to 720 mg/90 mg per day, supplemented with oral levodopa provided almost 2 additional hours per day of “Good On” time without troublesome
Primary analyses from this phase 3 clinical trial of the investigational, subcutaneous infusion of levodopa/carbidopa (LD/CD) (ND0612) showed that treatment in doses of up to 720 mg/90 mg per day, supplemented with oral levodopa provided almost 2 additional hours per day of “Good On” time without troublesome
Farooqji
in
Cure Parkinson's
3 months ago
Ultrasound result and am now panicking
Hi, I wonder if anyone could offer some words of wisdom, I had an ultrasound yesterday and the sonographer said I had some fat in my liver, nothing to worry about. A week for results to GP. Phone call today from receptionist for urgent bloods, in a week and appt with GP, in 2 weeks. Asked to speak to
Hi, I wonder if anyone could offer some words of wisdom, I had an ultrasound yesterday and the sonographer said I had some fat in my liver, nothing to worry about. A week for results to GP. Phone call today from receptionist for urgent bloods, in a week and appt with GP, in 2 weeks. Asked to speak to
Owlie
in
British Liver Trust
3 months ago
Low cortisol
rheumatologist referred me to endocrinologist as Cortisol levels low He booked me in for a synacthen test. Which I had 3 weeks ago. I havnt got an appointment with him till end of August. I contacted his secretary who spoke to him and he said that level was inadequate and to continue with 5 mg of
rheumatologist referred me to endocrinologist as Cortisol levels low He booked me in for a synacthen test. Which I had 3 weeks ago. I havnt got an appointment with him till end of August. I contacted his secretary who spoke to him and he said that level was inadequate and to continue with 5 mg of
Creamtea
in
PMRGCAuk
3 months ago
update
Update on my post “What should I do”, thank you for all your helpful replies. I had my COVID Jab and no after effects from that. I am seeing the Surgery Nurse to have my leg dressed twice a week.The haematoma is slow to heal due to the blood thinning medication but Hopefully it will heal soon. I heard
Update on my post “What should I do”, thank you for all your helpful replies. I had my COVID Jab and no after effects from that. I am seeing the Surgery Nurse to have my leg dressed twice a week.The haematoma is slow to heal due to the blood thinning medication but Hopefully it will heal soon. I heard
Macas
in
PMRGCAuk
3 months ago
Ablation appointment take two …..
Deep breath and all fingers crossed, I’ve been given provisional appointment for cryoablation end of this month. They need to use an internal echocardiogram on me (ICE) due to previous heart surgery and clot risk. There is only one such thing in the locality which is why they had to cancel todays appointment
Deep breath and all fingers crossed, I’ve been given provisional appointment for cryoablation end of this month. They need to use an internal echocardiogram on me (ICE) due to previous heart surgery and clot risk. There is only one such thing in the locality which is why they had to cancel todays appointment
Rainfern
in
AF Association
1 year ago
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