Experiences with
Methimazole154 public posts
MCT8 is Downregulated by Short Time Iodine Overload in the Thyroid Gland of Rats
The inhibition of thyroperoxidase activity by methimazole prevented the inhibitory effect of NaI on thyroid monocarboxylate transporter 8 expression, suggesting that an active thyroperoxidase is necessary for MCT8 downregulation by iodine overload, similarly to other thyroid markers, such as sodium iodide
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T3 and vascular calcification
Methimazole (400 mg/L) blocked the beneficial effect of T3 on VC. These results suggested that T3 can inhibit VC development.
PMID:
25416842
[PubMed - as supplied by publisher] [/i]
http://www.ncbi.nlm.nih.gov/pubmed/25416842
Rod
Agranulocytosis: carbimazole, methimazole and propylthiouracil
There are other causes but in this forum I guess the interest will be when it is caused by the anti-thyroid medicines: carbimazole, methimazole (not used in the UK) and propylthiouracil.
Over-the-Counter Drug-Induced Thyroid Disorders
Results: Case 1 involved acute exacerbation of thyrotoxicosis induced by taking OTC Tri-iodine TM in a 35-year-old woman while still on methimazole therapy.
Falsely Undetectable TSH in a Cohort of South Asian Euthyroid Patients
Half of these individuals were initially treated based on repeated falsely undetectable TSH values (seven euthyroid patients were treated with methimazole; two hypothyroid patients had doses of levothyroxine decreased).
Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compound
To establish patterns predictive effects on the thyroid, animals have been treated with reference compounds directly acting on the thyroid hormone formation (such as methimazole, ethylenethiourea) as well as liver enzyme inducers leading to an increased excretion of thyroid hormones and therewith to
Over-the-Counter-Drug-Induced Thyroid Disorders
[Added 13:10 27/03/2013 - Methimazole is like carbimazole - an anti-thyroid medicine used for treating Graves' disease.]
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism
Development of hyperthyroidism was assessed as initiation of methimazole or propylthiouracil up to a 13-year period. Risk of hyperthyroidism was analysed by Poisson regression models adjusted for important confounders such as amiodarone treatment.