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Interview: “Fresh” CAR-T cells for Richter's Transformation?Interview with Dr. John & Dr. Arnon Nagler
PLEASE TURN ON CLOSED CAPTIONS ("CC") FOR VIDEO SUBTITLES. https://cllsociety.org/2021/04/ash-2020-dr-arnon-nagler-on-safety-and-efficacy-of-cd19-car-t-cells-in-richters-transformation-after-targeted-therapy-for-chronic-
lymphocytic
-
leukemia
-cll/
PLEASE TURN ON CLOSED CAPTIONS ("CC") FOR VIDEO SUBTITLES. https://cllsociety.org/2021/04/ash-2020-dr-arnon-nagler-on-safety-and-efficacy-of-cd19-car-t-cells-in-richters-transformation-after-targeted-therapy-for-chronic-
lymphocytic
-
leukemia
-cll/
bkoffman
CLL CURE Hero
in
CLL Support
3 years ago
Doubling of absolute Lymphoctes
It has been 11 months now since I was diagnosed with CLL. Thereafter I have been tracking my WBC and Lymphocytes . The trend curve over a year is in the attached picture. I was also taking green tea extract , curcumin , vitamin C and D since being diagnosed. Until now did not experience any B symptoms
It has been 11 months now since I was diagnosed with CLL. Thereafter I have been tracking my WBC and Lymphocytes . The trend curve over a year is in the attached picture. I was also taking green tea extract , curcumin , vitamin C and D since being diagnosed. Until now did not experience any B symptoms
WilliamTan
in
CLL Support
3 years ago
Jakavi
I started Jakavi treatment some months ago as I was progressing from PV to myelofibrosis. I had immediate relief from itching but it seems to have returned. Enlsrged spleen, haematocrit down, platelets low and white cells not well controlled. What now?
I started Jakavi treatment some months ago as I was progressing from PV to myelofibrosis. I had immediate relief from itching but it seems to have returned. Enlsrged spleen, haematocrit down, platelets low and white cells not well controlled. What now?
lucieboo
in
MPN Voice
3 years ago
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Functional Consequences of Mutations in Myeloproliferative Neoplasms
« Of great interest, a set of epigenetic mutations can co-exist with the phenotypic driver mutations in 35%–40% of MPNs. These epigenetic mutations, such as TET2, EZH2, ASXL1, or DNMT3A mutations, promote clonal hematopoiesis and increased fitness of aged hematopoietic stem cells in both clonal hematopoiesis
« Of great interest, a set of epigenetic mutations can co-exist with the phenotypic driver mutations in 35%–40% of MPNs. These epigenetic mutations, such as TET2, EZH2, ASXL1, or DNMT3A mutations, promote clonal hematopoiesis and increased fitness of aged hematopoietic stem cells in both clonal hematopoiesis
Manouche
in
MPN Voice
3 years ago
Getting frustrated with the delay approval of ropeg In the US
Sometimes I can't help to think if enough is being done for MPN sufferers. According to multiple research ropeg has shown superiority over hydroxyurea with Ultimate possible significant molecular response in a selective number of MNP patients. So why there's a delay in getting access
Sometimes I can't help to think if enough is being done for MPN sufferers. According to multiple research ropeg has shown superiority over hydroxyurea with Ultimate possible significant molecular response in a selective number of MNP patients. So why there's a delay in getting access
markgenious1981
in
MPN Voice
3 years ago
Someone please answer this
My sister was diagnosed in October with cml after she said she needed some blood work done from feeling unwell. She has developed a mutation that is resistant to most treatments. She is going down hill. Someone please answer my question. 1 year prior to her Lukiema she randomly had both retinas detached
My sister was diagnosed in October with cml after she said she needed some blood work done from feeling unwell. She has developed a mutation that is resistant to most treatments. She is going down hill. Someone please answer my question. 1 year prior to her Lukiema she randomly had both retinas detached
Natweb76
in
Leukaemia Support
3 years ago
Introduction of myself, PMF, from China
Hi, I'm Qi, from China, I'm 34 years old this year. I confirmed PMF in 2017. At that time, the splenomegaly was high, but it was not very high, and it was not so high all the time. These symptoms began to happen to me one after another as early as 2013. JAK2V617F gene mutation, there is only one mutation
Hi, I'm Qi, from China, I'm 34 years old this year. I confirmed PMF in 2017. At that time, the splenomegaly was high, but it was not very high, and it was not so high all the time. These symptoms began to happen to me one after another as early as 2013. JAK2V617F gene mutation, there is only one mutation
merlisa
in
MPN Voice
3 years ago
Leukaemia Care Interview
Hello all, I have just finished recording an interview with Leukaemia Care for use in their Spot Leukaemia Early publicity in September. I think it went well and covered my story from pre diagnosis through to where I am now. I spoke about first finding a raised lymph node and the progression of ultra
Hello all, I have just finished recording an interview with Leukaemia Care for use in their Spot Leukaemia Early publicity in September. I think it went well and covered my story from pre diagnosis through to where I am now. I spoke about first finding a raised lymph node and the progression of ultra
kitchengardener2
in
CLL Support
3 years ago
Scientists discover novel oncogenic driver gene in human lung cancer
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
2greys
in
Lung Conditions Community Forum
3 years ago
Transplant at age 68 or not
I've had myelofibrosis for about 30 years and been on ruxolitinib successfully for about 8 years. We have just moved to Scotland and my new consultant has laid it on the line that rux doesn't go on working for ever and my only other option is transplant. This seems right to me but I am very nervous about
I've had myelofibrosis for about 30 years and been on ruxolitinib successfully for about 8 years. We have just moved to Scotland and my new consultant has laid it on the line that rux doesn't go on working for ever and my only other option is transplant. This seems right to me but I am very nervous about
Bullace
in
MPN Voice
3 years ago
Nutrition and Cll
I was diagnosed with Cll 3 months ago but my GP doctor suspected it a year ago. I am on W&W. I am wondering if I need to be on any kind of special diet and what supplements to take or not to take? The hematologist asked for a list of prescriptions and supplements I take but did not comment on them.
I was diagnosed with Cll 3 months ago but my GP doctor suspected it a year ago. I am on W&W. I am wondering if I need to be on any kind of special diet and what supplements to take or not to take? The hematologist asked for a list of prescriptions and supplements I take but did not comment on them.
sugar03
in
CLL Support
3 years ago
MBL is now CLL
Hi all, My MBL has progressed to CLL stage 1 after 8 years which I am struggling to come to terms with. I am now 51. Small glands in neck and groin and possibly a slightly enlarged spleen my lymphocytes were around 12-14 For couple of years but shot up to 24 recently. I am getting scams in 3 months.
Hi all, My MBL has progressed to CLL stage 1 after 8 years which I am struggling to come to terms with. I am now 51. Small glands in neck and groin and possibly a slightly enlarged spleen my lymphocytes were around 12-14 For couple of years but shot up to 24 recently. I am getting scams in 3 months.
Billy_Oz
in
CLL Support
3 years ago
8 months
So after 8 months on Ibrutinib my spleen is close to normal size, my blood count is normal, but 1/4 to 1/3 of my lymphocytes are still CLL. Side effects are gone, although I do get the odd day with stiff joints. Great progress, and my life is almost normal again. I didn’t respond to the Covid vaccines
So after 8 months on Ibrutinib my spleen is close to normal size, my blood count is normal, but 1/4 to 1/3 of my lymphocytes are still CLL. Side effects are gone, although I do get the odd day with stiff joints. Great progress, and my life is almost normal again. I didn’t respond to the Covid vaccines
809123
in
CLL Support
3 years ago
Chronic Lymphocytic Leukemia - CLL: When Being Fully Vaccinated for Covid-19 Doesn’t Mean Fully Protected
Here is the identical locked post for those who prefer to comment in the CLL Support community [/i] https://healthunlocked.com/cllsupport/posts/private/146150380/chronic-
lymphocytic
-
leukemia
-cll-when-being-fully-vaccinated-for-covid-19-doesn%E2%80%99t-mean-fully-protected
[i] ] [/i]
Recent
Here is the identical locked post for those who prefer to comment in the CLL Support community [/i] https://healthunlocked.com/cllsupport/posts/private/146150380/chronic-
lymphocytic
-
leukemia
-cll-when-being-fully-vaccinated-for-covid-19-doesn%E2%80%99t-mean-fully-protected
[i] ] [/i]
Recent
KatieBlue
in
CLL Support
3 years ago
Relapsing on Ibrutinib
Hello everyone, as I mention here a few weeks ago, my treatment with Ibrutinib is going to end soon due to (Dr. thinks) a mutation. I am going to see the Oncologist in 2 weeks and I have to make a decision which treatment I want to be put on. There are two options open for me. One is Venetoclax and
Hello everyone, as I mention here a few weeks ago, my treatment with Ibrutinib is going to end soon due to (Dr. thinks) a mutation. I am going to see the Oncologist in 2 weeks and I have to make a decision which treatment I want to be put on. There are two options open for me. One is Venetoclax and
Doremefasol
in
CLL Support
3 years ago
Greater Understanding of PV, ET Drives Potential New Treatment Options
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
Manouche
in
MPN Voice
3 years ago
From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
Jm954
Administrator
in
CLL Support
3 years ago
STELLAR Trial in the UK for Richter's
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Jm954
Administrator
in
CLL Support
3 years ago
I have had both doses of the Pfizer vaccine, while they applauded me after I got my 2nd dose, 90 days later I found that I have no immunity!
I took Ibrutinib prior to January 20 when it gave me AFib and a few other problems, then stated Venetoclax in July of 2020, and in August started the first of six doses of Rituxan. It would seem that Rituxan is the main culprit, as in my research I found that no immunity was created in cases which
I took Ibrutinib prior to January 20 when it gave me AFib and a few other problems, then stated Venetoclax in July of 2020, and in August started the first of six doses of Rituxan. It would seem that Rituxan is the main culprit, as in my research I found that no immunity was created in cases which
KevinCLLITP
in
CLL Support
3 years ago
Ruxolitinib discontinuation in polycythemia vera:
« After discontinuation, only 4 patients (18 %) received subsequent cytoreductive therapy, including hydroxyurea in one patient and pegylated interferon α-2a in three patients »… « discontinuation of ruxolitinib in PV was associated with generally favorable outcomes. However, there is a lack of available
« After discontinuation, only 4 patients (18 %) received subsequent cytoreductive therapy, including hydroxyurea in one patient and pegylated interferon α-2a in three patients »… « discontinuation of ruxolitinib in PV was associated with generally favorable outcomes. However, there is a lack of available
Manouche
in
MPN Voice
3 years ago
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