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Lymphocytic leukemia
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Pelabresib in Combination With Ruxolitinib for Myelofibrosis
“To our knowledge, the MANIFEST trial in JAKi treatment-naïve patients is the first study with a rational combination of BETi pelabresib and ruxolitinib that showed clinically meaningful durable improvements in splenomegaly and symptoms, was associated with biomarker findings indicating potential disease
“To our knowledge, the MANIFEST trial in JAKi treatment-naïve patients is the first study with a rational combination of BETi pelabresib and ruxolitinib that showed clinically meaningful durable improvements in splenomegaly and symptoms, was associated with biomarker findings indicating potential disease
Manouche
in
MPN Voice
1 year ago
Support ,tears , questions. Low hemoglobin . Severe pain l4l5 s1. ( Facet injections failed ) . Severely anemic ,three months bed ridden
He has secondary chronic
lymphocytic
leukemia
stage 0 as of last year . I'm frustrated bc I can't get him a blood transfusion he needs bc his Dr won't do it unless he's signed up for lu177 which he is but idk when bc my mind is spinning.
He has secondary chronic
lymphocytic
leukemia
stage 0 as of last year . I'm frustrated bc I can't get him a blood transfusion he needs bc his Dr won't do it unless he's signed up for lu177 which he is but idk when bc my mind is spinning.
Daddyishealing
in
Fight Prostate Cancer
1 year ago
Help understanding my BMB results
Just an update, I have received my post clinic letter from my consultant and the results of the genetic tests are now in. CALR mutated 9 no deletion- neither type 1 nor type 2 ( probably best described as type 2 like) Post ET MF on bone marrow - CALR, IDH2, TET2 mutation s and no copy number abnormalities
Just an update, I have received my post clinic letter from my consultant and the results of the genetic tests are now in. CALR mutated 9 no deletion- neither type 1 nor type 2 ( probably best described as type 2 like) Post ET MF on bone marrow - CALR, IDH2, TET2 mutation s and no copy number abnormalities
UKZA
in
MPN Voice
1 year ago
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Besremi Titration Questions
I am 50yo diagnosed with PV/JAK2+ since 2018. I went through HU and then Jakafi before MPN specialist at Johns Hopkins recommended switching to Besremi for longer term complete blood response. I started Besremi titration Dec 21, 2022 at 100mcg. I have been increasing 50mcg every 2 weeks after CBC checks
I am 50yo diagnosed with PV/JAK2+ since 2018. I went through HU and then Jakafi before MPN specialist at Johns Hopkins recommended switching to Besremi for longer term complete blood response. I started Besremi titration Dec 21, 2022 at 100mcg. I have been increasing 50mcg every 2 weeks after CBC checks
RyanCB
in
MPN Voice
1 year ago
NEW DISCOVERIES WITH RICHTERS
I just read an article that I felt would interest a significant number of our members, so I'm providing a link to it here: https://www.dana-farber.org/newsroom/news-releases/2022/scientists-map-genetic-evolution-of-chronic-
lymphocytic
-
leukemia
-to-richter-s-syndrome/ As a patient at Dana Farber I get
I just read an article that I felt would interest a significant number of our members, so I'm providing a link to it here: https://www.dana-farber.org/newsroom/news-releases/2022/scientists-map-genetic-evolution-of-chronic-
lymphocytic
-
leukemia
-to-richter-s-syndrome/ As a patient at Dana Farber I get
wizzard166
in
CLL Support
1 year ago
UK NICE Approves Ibrutinib +Venetoclax for First Line treatment for ALL Patients from today
Probably one of the best news stories that we have been able to announce in many years for patients in England and Wales. We are absolutely delighted that this effective treatment is now available for ALL CLL patients as their first treatment if their doctor feels it is appropriate. This treatment
Probably one of the best news stories that we have been able to announce in many years for patients in England and Wales. We are absolutely delighted that this effective treatment is now available for ALL CLL patients as their first treatment if their doctor feels it is appropriate. This treatment
Jm954
Administrator
in
CLL Support
1 year ago
Expression of TCL1A gene is found to drive onset of blood cancer
[i]One of the causes of blood cancer is non-inherited mutations in blood stem cells that can lead to the cancerous growth of abnormal cells. Reporting in Nature, scientists now suggest that targeting a gene called TCL1A may be able to suppress such growth and decrease the risk of blood cancer....[/i]
[i]One of the causes of blood cancer is non-inherited mutations in blood stem cells that can lead to the cancerous growth of abnormal cells. Reporting in Nature, scientists now suggest that targeting a gene called TCL1A may be able to suppress such growth and decrease the risk of blood cancer....[/i]
bennevisplace
in
CLL Support
1 year ago
Optimal Treatment Combinations in the Management of CLL/SLL Jeff Sharman, MD Provided by Clinical Care Options, LLC
-
Overview
Treatment choices in chronic
lymphocytic
leukemia
(CLL)/small
lymphocytic
lymphoma (SLL) have rapidly expanded in the past decade.
-
Overview
Treatment choices in chronic
lymphocytic
leukemia
(CLL)/small
lymphocytic
lymphoma (SLL) have rapidly expanded in the past decade.
lankisterguy
Volunteer
in
CLL Support
2 years ago
Doctor cannot fully diagnose without bone marrow biopsy and PET scan?
The overall immunophenotype is compatible with chronic
lymphocytic
leukemia
/small
lymphocytic
lymphoma, although not entirely specific. The number of these cells based on the concurrent CBC is 1.9 k/uL, less than the 5.0 k/uL generally required for a diagnosis of chronic
lymphocytic
leukemia
.
The overall immunophenotype is compatible with chronic
lymphocytic
leukemia
/small
lymphocytic
lymphoma, although not entirely specific. The number of these cells based on the concurrent CBC is 1.9 k/uL, less than the 5.0 k/uL generally required for a diagnosis of chronic
lymphocytic
leukemia
.
SunCalifornia
in
CLL Support
2 years ago
Oncology Learning Network CME- Emerging Treatments for CLL / SLL included in NCCN and ESMO guidelines
leukemia
, acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.
leukemia
, acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.
lankisterguy
Volunteer
in
CLL Support
2 years ago
More on Cimetidine (Tagamet) and CLL & NK Cell improvements
”Peripheral blood natural killer (NK) activity in patients with B-cell chronic
lymphocytic
leukemia
(B-CLL) is frequently low or absent.
”Peripheral blood natural killer (NK) activity in patients with B-cell chronic
lymphocytic
leukemia
(B-CLL) is frequently low or absent.
Rando21
in
CLL Support
2 years ago
My chemo experience
I started with fludarabine and rituximab which wasn't great. I had feelings of hot and cold, spots before my eyes, vertigo and blacking out. My haematologist was there in minutes, lowered my dose and I was able to complete the course over 6 hours without further adverse effects. Subsequent treatments
I started with fludarabine and rituximab which wasn't great. I had feelings of hot and cold, spots before my eyes, vertigo and blacking out. My haematologist was there in minutes, lowered my dose and I was able to complete the course over 6 hours without further adverse effects. Subsequent treatments
kiwiCanuck
in
CLL Support
1 year ago
SCT while feeling well
I have been put forward for a SCT, providing a further heart scan is ok. I have Post ET Myelofibrosis, MPL positive, I also have another mutation, which I’ve been told will increase my chances of getting leukaemia. I have pretty much decided I will go through with it, but know it will be very tough.
I have been put forward for a SCT, providing a further heart scan is ok. I have Post ET Myelofibrosis, MPL positive, I also have another mutation, which I’ve been told will increase my chances of getting leukaemia. I have pretty much decided I will go through with it, but know it will be very tough.
SRH55
in
MPN Voice
1 year ago
New and Emerging Treatments for Newly Diagnosed and R/R CLL/SLL: Targeted Inhibitors - Dr. Susan O'Brien
This webcast on new and emerging treatments for newly diagnosed and R/R CLL/SLL with a focus on targeted inhibitors, presented by Dr. Susan O'Brien is intended for medical professionals and uses moderate "Med-Speak." So only recommended for those accustomed to the medical language. But if you can follow
This webcast on new and emerging treatments for newly diagnosed and R/R CLL/SLL with a focus on targeted inhibitors, presented by Dr. Susan O'Brien is intended for medical professionals and uses moderate "Med-Speak." So only recommended for those accustomed to the medical language. But if you can follow
lankisterguy
Volunteer
in
CLL Support
1 year ago
Interesting
Clinical Review of ropeginterferon alfa-2b Suggests Amended Dosing Schedule May Support Improved Clinical Outcomes in Polycythemia Vera Review of studies published in Frontiers in Oncology highlights dosing considerations that may help more patients achieve earlier complete hematological response
Clinical Review of ropeginterferon alfa-2b Suggests Amended Dosing Schedule May Support Improved Clinical Outcomes in Polycythemia Vera Review of studies published in Frontiers in Oncology highlights dosing considerations that may help more patients achieve earlier complete hematological response
wateron
in
MPN Voice
1 year ago
Essential Thrombocythaemia and Pneumococcal vaccine safe to take?
hello my husband is 36 with Essential Thrombocythaemia Calr type 1 and on aspirin only he has received a letter for the Pneumococcal vaccine but I’m wondering is it safe to take with having ET?
hello my husband is 36 with Essential Thrombocythaemia Calr type 1 and on aspirin only he has received a letter for the Pneumococcal vaccine but I’m wondering is it safe to take with having ET?
Green1988
in
MPN Voice
1 year ago
Upcoming Events of Interest
[i]Just received an announcement from our friends at MPN Advocacy & Education International of some interesting upcoming events. [/i] [u]
Webinars
[/u] A Conversation with an MPN Specialist: Everything You Should Know About Clinical Trials Tuesday, February 28, 2023 1:30 - 3:00 pm EST
[i]Just received an announcement from our friends at MPN Advocacy & Education International of some interesting upcoming events. [/i] [u]
Webinars
[/u] A Conversation with an MPN Specialist: Everything You Should Know About Clinical Trials Tuesday, February 28, 2023 1:30 - 3:00 pm EST
hunter5582
in
MPN Voice
1 year ago
APS - Increased Risk of Blood Clots
Has anyone with an MPN with JAK-2 had an Extended Antiphospholipid Profile done? These blood tests check your antibodies (immunoglobulin) which are protective proteins (made by your plasma cells - WBC) produced by your immune system. They attach to foreign substances (antigens) such as bacteria, fungi
Has anyone with an MPN with JAK-2 had an Extended Antiphospholipid Profile done? These blood tests check your antibodies (immunoglobulin) which are protective proteins (made by your plasma cells - WBC) produced by your immune system. They attach to foreign substances (antigens) such as bacteria, fungi
Buggerbear
in
MPN Voice
1 year ago
Allogenic Stem Cell Transplant
I [i]received a Stem cell transplant six months ago. My decision was based on the availability of a suitable donor and being able to get to remission through aggressive chemotherapy. Other treatments had no effect on my rapidly growing leukemia. As of today I’m still in remission, showing 97% chimerism
I [i]received a Stem cell transplant six months ago. My decision was based on the availability of a suitable donor and being able to get to remission through aggressive chemotherapy. Other treatments had no effect on my rapidly growing leukemia. As of today I’m still in remission, showing 97% chimerism
GarciaB
in
MPN Voice
1 year ago
Doctor mentioned Richters???
I am on the Bruin trial and was randomized to Arm B which is Idelalisib and Rituximab ( 6 months of infusions ). My bloodwork so far has shown slight improvement since the start in January of this year. Now at my last blood work and appointment the doctor has noticed some lymph nodes increasing in size
I am on the Bruin trial and was randomized to Arm B which is Idelalisib and Rituximab ( 6 months of infusions ). My bloodwork so far has shown slight improvement since the start in January of this year. Now at my last blood work and appointment the doctor has noticed some lymph nodes increasing in size
rcusher
in
CLL Support
1 year ago
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