I expect you already know that CALR is the driver mutation that caused the MPN. Others on the forum who have the CALR mutation are more knowledgeable and can speak better to their experience with it. Here are a few references.
"Type 2-like CALR mutations were preferentially associated with an essential thrombocythemia phenotype, low risk of thrombosis despite very-high platelet counts and indolent clinical course." ncbi.nlm.nih.gov/pmc/articl....
IDH2 and TET2 are non-driver mutations that are associated with MPN risk of progression. I also have a non-driver mutation present, in my case a germline NF1 mutation. There is information in the literature about non-driver mutations. Here a a few examples.
DIPSS+, MIPSS70+, MYSEC-PM are all standardized MPN risk calculators. You can look up the meanings of the various scores on-line. Note that these scores are statistical projections. They cannot tell you all that you need to know about your individual prognosis.
Given that you have findings to discuss and likely some very reasonable concerns, suggest that you insist on an in-person appointment. I do not know whether you are consulting with a MPN Specialist. rather than a regular hematologist. This would certainly be the time to consult directly with a MPN Specialist if you are not already doing so.
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