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Autopsies tell us the secrets of Parkinson's...
The brains of Parkinson's patients tell us some of the secrets of the disease at autopsy... "For History must be our deliverer, not only from the undue influence of other times, but from the undue influence of our own, from the tyranny of environment and the pressure of the air we breathe". Acton.
The brains of Parkinson's patients tell us some of the secrets of the disease at autopsy... "For History must be our deliverer, not only from the undue influence of other times, but from the undue influence of our own, from the tyranny of environment and the pressure of the air we breathe". Acton.
parkinsonshereandnow
in
Cure Parkinson's
3 years ago
The more homocysteine, the worse the Parkinson's?
"You don't discover new continents if you don't have the courage to lose sight of the old shores." Andre Gide An elevated level of the amino acid homocysteine in the blood is neurotoxic and has been reported as a truly important risk factor for developing Parkinson's, as well as cardiovascular disease
"You don't discover new continents if you don't have the courage to lose sight of the old shores." Andre Gide An elevated level of the amino acid homocysteine in the blood is neurotoxic and has been reported as a truly important risk factor for developing Parkinson's, as well as cardiovascular disease
parkinsonshereandnow
in
Cure Parkinson's
3 years ago
Can we prevent, slow or halt, improve symptoms and reduce the severity of Parkinson's?
"Some things from the past are gone but others open a gap to the future and they are the ones I want to rescue." Mario Benedetti Current Neurology, which has made undeniable advances against Parkinson's, tells us that the disease is degenerative and symptoms are getting worse over the years, despite
"Some things from the past are gone but others open a gap to the future and they are the ones I want to rescue." Mario Benedetti Current Neurology, which has made undeniable advances against Parkinson's, tells us that the disease is degenerative and symptoms are getting worse over the years, despite
parkinsonshereandnow
in
Cure Parkinson's
3 years ago
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Levodopa vs. Mucuna Pruriens, How Similar Are They And Which One Is More Effective?
These two are discussed quite frequently on the forum so I decided to do some reading about them. Some members have reported better effects with Mucuna Pruriens (MP) while others are quite happy with Levodopa (L-Dopa) and see no need to to try anything else. Some on this forum have mentioned previously
These two are discussed quite frequently on the forum so I decided to do some reading about them. Some members have reported better effects with Mucuna Pruriens (MP) while others are quite happy with Levodopa (L-Dopa) and see no need to to try anything else. Some on this forum have mentioned previously
chartist
in
Cure Parkinson's
4 years ago
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
Niacin PD patients are found to have significantly decreased niacin levels compared to age-matched healthy controls [52]. This has been attributed to both the disease itself and the medication used to attenuate motor symptoms [58]. Sinemet, the most commonly used PD medication, includes carbidopa, which
Niacin PD patients are found to have significantly decreased niacin levels compared to age-matched healthy controls [52]. This has been attributed to both the disease itself and the medication used to attenuate motor symptoms [58]. Sinemet, the most commonly used PD medication, includes carbidopa, which
Farooqji
in
Cure Parkinson's
4 years ago
Controlled Release Carbidopa Levodopa
https://journeywithparkinsons.com/2020/11/27/treating-parkinsons-with-carbidopa-levodopa/amp/?__twitter_impression=true
https://journeywithparkinsons.com/2020/11/27/treating-parkinsons-with-carbidopa-levodopa/amp/?__twitter_impression=true
Hidden
in
Cure Parkinson's
4 years ago
Effects on Parkinson's disease patients chronically treated with L-dopa
L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias. Despite extensive research on L-dopa-induced dyskinesia, its pathogenesis remains poorly
L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias. Despite extensive research on L-dopa-induced dyskinesia, its pathogenesis remains poorly
Farooqji
in
Cure Parkinson's
4 years ago
Manganese?
I've always wondered about the PD diagnosis because I don't respond to Sinemet. So what else might be involved? For the past 30 years my hobby has been restoring 1960s-era VWs. Which involved a lot of welding using my cheap flux wire mig welder. And never using a mask. Some of the early
I've always wondered about the PD diagnosis because I don't respond to Sinemet. So what else might be involved? For the past 30 years my hobby has been restoring 1960s-era VWs. Which involved a lot of welding using my cheap flux wire mig welder. And never using a mask. Some of the early
kaypeeoh
in
Cure Parkinson's
4 years ago
Age-Adjusted Death Rates* for Parkinson Disease† Among Adults Aged ≥65 Years — National Vital Statistics System, United States, 1999–2017
Age-Adjusted Death Rates* for Parkinson Disease† Among Adults Aged ≥65 Years — National Vital Statistics System, United States, 1999–2017 "From 1999 to 2017, age-adjusted death rates for Parkinson disease among adults aged ≥65 years increased from 41.7 to 65.3 per 100,000 population. Among men, the
Age-Adjusted Death Rates* for Parkinson Disease† Among Adults Aged ≥65 Years — National Vital Statistics System, United States, 1999–2017 "From 1999 to 2017, age-adjusted death rates for Parkinson disease among adults aged ≥65 years increased from 41.7 to 65.3 per 100,000 population. Among men, the
sharoncrayn
in
Cure Parkinson's
4 years ago
90% paralysed from the waist down when OFF the influence of L-Dopa. Does anyone share these symptoms ?
While getting up in the morning, with virtually no L-Dopa “coverage” I’m practically incapable of walking the 3 meters that separates the bed from the bathroom. The legs will simply not obey. Also during the day, if I fail to take my next dose in time, within minutes my forward motion is almost impossible
While getting up in the morning, with virtually no L-Dopa “coverage” I’m practically incapable of walking the 3 meters that separates the bed from the bathroom. The legs will simply not obey. Also during the day, if I fail to take my next dose in time, within minutes my forward motion is almost impossible
9Rafiki9
in
Cure Parkinson's
4 years ago
Avoid levodopa phobia
I was reading Simon’s latest article about the PD drug development pipeline, which is a good read anyway - https://scienceofparkinsons.com/2020/12/02/drug-pipeline/ - and watched this video from Dr Kelly Mills of Johns Hopkins University about disease-modifying vs symptomatic therapy - https://youtu.be
I was reading Simon’s latest article about the PD drug development pipeline, which is a good read anyway - https://scienceofparkinsons.com/2020/12/02/drug-pipeline/ - and watched this video from Dr Kelly Mills of Johns Hopkins University about disease-modifying vs symptomatic therapy - https://youtu.be
Cagey84
in
Cure Parkinson's
4 years ago
"Alternative" treatments are not harmless when whey cost you quality of life
It's common to read on this forum that alternatives are harmless and have no side effects. But what about when a PWP eschews traditional treatment in favour of an alternative, and their quality of life suffers as a result? All we have is the immediate future. Today. Probably tomorrow. Maybe the day
It's common to read on this forum that alternatives are harmless and have no side effects. But what about when a PWP eschews traditional treatment in favour of an alternative, and their quality of life suffers as a result? All we have is the immediate future. Today. Probably tomorrow. Maybe the day
Hidden
in
Cure Parkinson's
4 years ago
Levodopa question
Do people find increasing their levodopa dosage helps extend their on time for longer or improves the quality of their on time?
Do people find increasing their levodopa dosage helps extend their on time for longer or improves the quality of their on time?
Parkinsonjisung
in
Cure Parkinson's
4 years ago
Tomatoes engineered to produce vital Parkinson’s disease medicine
https://newatlas.com/science/tomatoes-engineered-parkinsons-disease-levodopa/ The part of this article I find most interesting is this, for the deniers... Alongside presenting a novel mode of manufacturing, the study hypothesizes this naturally produced form of the molecule may help reduce the adverse
https://newatlas.com/science/tomatoes-engineered-parkinsons-disease-levodopa/ The part of this article I find most interesting is this, for the deniers... Alongside presenting a novel mode of manufacturing, the study hypothesizes this naturally produced form of the molecule may help reduce the adverse
Erniediaz1018
in
Cure Parkinson's
4 years ago
Tomato crop enriched with Parkinson's disease drug created
Scientists want to create a production pipeline of a tomato crop enriched with the Parkinson's disease drug L-DOPA, giving patients new access to one of the world's most essential medicines. The development of the genetically modified (GM) tomato, led by British researchers, has implications for developing
Scientists want to create a production pipeline of a tomato crop enriched with the Parkinson's disease drug L-DOPA, giving patients new access to one of the world's most essential medicines. The development of the genetically modified (GM) tomato, led by British researchers, has implications for developing
Farooqji
in
Cure Parkinson's
4 years ago
Phase 2b Trial of Prasinezumab in Patients With Early Parkinson’s Expected by 2021
Note:. Prior apologies if someone has already posted it. I am posting this as this is one of the main pipeline item in the ongoing PD trials. Failure or success of future therapies will greatly depend upon the results of this trial. Roche, in partnership with Prothena, will launch a Phase 2b clinical
Note:. Prior apologies if someone has already posted it. I am posting this as this is one of the main pipeline item in the ongoing PD trials. Failure or success of future therapies will greatly depend upon the results of this trial. Roche, in partnership with Prothena, will launch a Phase 2b clinical
Farooqji
in
Cure Parkinson's
4 years ago
Botox For Dystonia
Well im climbing out the rabbit hole of covid hell.........scheduled for spinal unilateral botox injections over the mountains 28th december ,university hospital Denver, to alleviate MASSIVE cervical etc dystonic pain hoollllaayyyy! bring on the botox next stop the pump for Apomrphine and a seperate
Well im climbing out the rabbit hole of covid hell.........scheduled for spinal unilateral botox injections over the mountains 28th december ,university hospital Denver, to alleviate MASSIVE cervical etc dystonic pain hoollllaayyyy! bring on the botox next stop the pump for Apomrphine and a seperate
beehive23
in
Cure Parkinson's
4 years ago
Researchers have devised a way to upcycle waste into the Parkinson’s disease drug L-DOPA
Associate professor Yan Ning and assistant professor Zhou Kang from NUS Chemical and Biomolecular Engineering led the team that devised a method to turn shells from prawns and crabs into L-DOPA, a common drug for treating Parkinson’s disease. A similar method can convert wood waste to proline, which
Associate professor Yan Ning and assistant professor Zhou Kang from NUS Chemical and Biomolecular Engineering led the team that devised a method to turn shells from prawns and crabs into L-DOPA, a common drug for treating Parkinson’s disease. A similar method can convert wood waste to proline, which
Farooqji
in
Cure Parkinson's
4 years ago
Home Test with L-Dopa?
Hey Folks, I am suspecting Parkinsons (Have the cogwheel rigidity) and I ordered some L-Dopa. Would this work without the Decarboxylase Inhibitor? If not, is there something else I can add to see if it improves symptoms? I am in lively contact with doctors and visiting one soon, but I would like answers
Hey Folks, I am suspecting Parkinsons (Have the cogwheel rigidity) and I ordered some L-Dopa. Would this work without the Decarboxylase Inhibitor? If not, is there something else I can add to see if it improves symptoms? I am in lively contact with doctors and visiting one soon, but I would like answers
FelixSMueller
in
Cure Parkinson's
4 years ago
Heart racing and Mucuna
Good morning all! I was looking up reasons as to why my heart races after I take even an eighth of a teaspoon of l-dopa powder which is actually Mucuna. I usually take 3 1/8 of a teaspoon of L tyrosine powder because a lot of the times the Mucuna has a tendency to make me nauseous or vomit. I came across
Good morning all! I was looking up reasons as to why my heart races after I take even an eighth of a teaspoon of l-dopa powder which is actually Mucuna. I usually take 3 1/8 of a teaspoon of L tyrosine powder because a lot of the times the Mucuna has a tendency to make me nauseous or vomit. I came across
MissRita
in
Cure Parkinson's
4 years ago
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