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World Cancer Day
Hence, CLL and other liquid cancers such as CML (chronic myelogenous leukemia) are the poster children for the development of biological (think monoclonal antibodies such as rituximab) and targeted non-chemo therapies such as
imatinib
or Gleevec for CML (the first truly targeted therapy and a true miracle
Hence, CLL and other liquid cancers such as CML (chronic myelogenous leukemia) are the poster children for the development of biological (think monoclonal antibodies such as rituximab) and targeted non-chemo therapies such as
imatinib
or Gleevec for CML (the first truly targeted therapy and a true miracle
bkoffman
CLL CURE Hero
in
CLL Support
8 years ago
New Discovery for MPN's
“[MSK physician-scientist] Charles Sawyers showed that a second-generation drug, dasatinib, worked in CML patients who failed
imatinib
because dasatinib binds to the target differently,” Dr. Levine says.
“[MSK physician-scientist] Charles Sawyers showed that a second-generation drug, dasatinib, worked in CML patients who failed
imatinib
because dasatinib binds to the target differently,” Dr. Levine says.
light
in
MPN Voice
9 years ago
Nobel Prize in Chemistry highlights how our bodies can repair our fragile DNA - and provides the basis for cancer treatments
This led to the development of
imatinib
/Gleevec, which dramatically increased the length of time patients with CML can survive with the disease: http://genetics.thetech.org/ask/ask298 Unfortunately, CLL researchers trying to achieve the same kind of breakthrough, have been disappointed to find that
This led to the development of
imatinib
/Gleevec, which dramatically increased the length of time patients with CML can survive with the disease: http://genetics.thetech.org/ask/ask298 Unfortunately, CLL researchers trying to achieve the same kind of breakthrough, have been disappointed to find that
AussieNeil
Partner
in
CLL Support
9 years ago
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If we don’t talk about value, cancer drugs will become terminal for health systems
[i]"In 2013, for example, group of experts in chronic myeloid leukemia described how the price of
imatinib
(Gleevec) increased three-fold over a decade.
[i]"In 2013, for example, group of experts in chronic myeloid leukemia described how the price of
imatinib
(Gleevec) increased three-fold over a decade.
AussieNeil
Partner
in
CLL Support
9 years ago
April Hematology Times: "How vitamin D fights lymphoma" and "Low doses of imatinib promote hematopoiesis"
Low doses of
promote hematopoiesis http://www.hematologytimes.com/p_article.do?id=5010 Perhaps this may prove a way of boosting our immunity if further research and trials are successful.
Imatinib
may be better known under its marketing name Gleevec.
Low doses of
promote hematopoiesis http://www.hematologytimes.com/p_article.do?id=5010 Perhaps this may prove a way of boosting our immunity if further research and trials are successful.
Imatinib
may be better known under its marketing name Gleevec.
AussieNeil
Partner
in
CLL Support
9 years ago
The future for CLL?
healthy cells,
imatinib
works as a form of targeted therapy—only cancer cells are killed through the drug's action."
healthy cells,
imatinib
works as a form of targeted therapy—only cancer cells are killed through the drug's action."
AussieNeil
Partner
in
CLL Support
9 years ago
Chemo makes resistant cancer stem cells???
(Ibruinib, Idelalisib,
Imatinib
), deacetylase inhibitors etc.? In CML the chosen therapy of
Imatinib
aka Gleevec still produces resistant cancer. Curiously to both "mammary carcinoma" and
Imatinib
relapsed CML patients, Dasatinib, a Src tyrosine kinase inhibitor, has shown efficacy.
(Ibruinib, Idelalisib,
Imatinib
), deacetylase inhibitors etc.? In CML the chosen therapy of
Imatinib
aka Gleevec still produces resistant cancer. Curiously to both "mammary carcinoma" and
Imatinib
relapsed CML patients, Dasatinib, a Src tyrosine kinase inhibitor, has shown efficacy.
ThreeWs
in
CLL Support
9 years ago
Imbruvica is on track to be a top seller for J&J and Pharmacyclics for years to come
Many are familiar to us; Imbruvica of course and Revlimid (Lenalidomide), Rituxan (Rituximab/Mabthera) and perhaps Gleevec (
Imatinib
), the drug that did for CML what we are still looking for with CLL.
Many are familiar to us; Imbruvica of course and Revlimid (Lenalidomide), Rituxan (Rituximab/Mabthera) and perhaps Gleevec (
Imatinib
), the drug that did for CML what we are still looking for with CLL.
AussieNeil
Partner
in
CLL Support
10 years ago
Musculosceletal pain even after TKI treatment
(TKI) such as
imatinib
(Gleevec).
(TKI) such as
imatinib
(Gleevec).
zevkalman
in
CLL Support
10 years ago
LEVOTHYROXINE INTERACTIONS - useful list
Other drugs that may increase elimination of thyroid hormone include
imatinib
(GLEEVEC), which is used to treat leukemia and other cancers and may result in hypothyroidism when used together with levothyroxine.
Other drugs that may increase elimination of thyroid hormone include
imatinib
(GLEEVEC), which is used to treat leukemia and other cancers and may result in hypothyroidism when used together with levothyroxine.
Hidden
in
Thyroid UK
11 years ago
Drugs/food and drink that interfere with Levothyroxine Absorption
John’s wort OTHER DRUGS
imatinib
(GLEEVEC) sertraline (ZOLOFT)** Interactions that result in changes of levothyroxine binding in blood Estrogens Interaction that results in increased or decreased levels of other drugs warfarin (COUMADIN)
John’s wort OTHER DRUGS
imatinib
(GLEEVEC) sertraline (ZOLOFT)** Interactions that result in changes of levothyroxine binding in blood Estrogens Interaction that results in increased or decreased levels of other drugs warfarin (COUMADIN)
Nathalina
in
Thyroid UK
11 years ago
Has anyone had any experience of Afatinib?
In order to support a submission to the Scottish medicines consortium (SMC) for the availability of Afatinib (Gilotrif) which is a targeted (biological) therapy it would be helpful to hear from anyone that may have experience of it either through your Consultant or as part of a clinical trial
In order to support a submission to the Scottish medicines consortium (SMC) for the availability of Afatinib (Gilotrif) which is a targeted (biological) therapy it would be helpful to hear from anyone that may have experience of it either through your Consultant or as part of a clinical trial
Hidden
Roy Castle
in
The Roy Castle Lung Cancer Foundation
11 years ago
Just a quick update
I have just had my latest scan results, much earlier than expected. My November scan showed progression of the main tumour. It had gone from 11cms to collapsed and immeasurable in 8 months, this had remained so for another year. Then November showed it was 2cms x 3mm. We didn't know how long it had taken
I have just had my latest scan results, much earlier than expected. My November scan showed progression of the main tumour. It had gone from 11cms to collapsed and immeasurable in 8 months, this had remained so for another year. Then November showed it was 2cms x 3mm. We didn't know how long it had taken
Hidden
in
The Roy Castle Lung Cancer Foundation
11 years ago
Not the news I wanted to hear :((
Just returned from my oncology appointment, the one I have been waiting for to get the results of my latest CT scan. Not the best of news....I have some tumour progression. I knew It would happen eventually and did expect it as I've been coughing for the last 3 weeks but still it was a shock. I've been
Just returned from my oncology appointment, the one I have been waiting for to get the results of my latest CT scan. Not the best of news....I have some tumour progression. I knew It would happen eventually and did expect it as I've been coughing for the last 3 weeks but still it was a shock. I've been
Hidden
in
The Roy Castle Lung Cancer Foundation
12 years ago
Update from lung cancer study day and other things :)
Not written a post myself for a while although I always try to answer other posts and give some hope to others in a similar position to myself. I have had a very busy few weeks since coming back from the USA. We now have our support group up and running, our first 'official' meeting in 26th October
Not written a post myself for a while although I always try to answer other posts and give some hope to others in a similar position to myself. I have had a very busy few weeks since coming back from the USA. We now have our support group up and running, our first 'official' meeting in 26th October
Hidden
in
The Roy Castle Lung Cancer Foundation
12 years ago
Day 2 of taking Afatinib
My partner was diagnosed with stage 4 lung cancer (nsclc) in June 2009. He has had Chemotherapy, Radiotherapy & Tarceva. It has now spread to the spleen & he goes for a bone scan next week as they think it has also spread to his bones.He started taking the new unlicensed drug Afatinib yesterday & so
My partner was diagnosed with stage 4 lung cancer (nsclc) in June 2009. He has had Chemotherapy, Radiotherapy & Tarceva. It has now spread to the spleen & he goes for a bone scan next week as they think it has also spread to his bones.He started taking the new unlicensed drug Afatinib yesterday & so
VeeJayBee
in
The Roy Castle Lung Cancer Foundation
12 years ago
Does anyone know anybody who has been offered a new drug called Afatinib? My partner has been offered this as Tarceva has stopped working.
VeeJayBee
in
The Roy Castle Lung Cancer Foundation
12 years ago
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