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Enzalutamide
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Actinium shortage - oh no!!!
Just when I was about to start a promising new trial using 225Ac-J591, along with Keytruda +
Enzalutamide
- “While early clinical results from actinium-225-based radiopharmaceuticals have been promising, the extreme global shortage of actinium-225 has slowed research and development activities and made
Just when I was about to start a promising new trial using 225Ac-J591, along with Keytruda +
Enzalutamide
- “While early clinical results from actinium-225-based radiopharmaceuticals have been promising, the extreme global shortage of actinium-225 has slowed research and development activities and made
HopingForTheBest1
in
Advanced Prostate Cancer
3 years ago
Input?
Bo says I am M1 CRPC (I am not really sure if this is really the case), and he suggested either Abiraterone,
Enzalutamide
, or Radium-233. Will also see Ohio State Dr. Min Yin July 21 to see what he thinks. Any thoughts? Thanks
Bo says I am M1 CRPC (I am not really sure if this is really the case), and he suggested either Abiraterone,
Enzalutamide
, or Radium-233. Will also see Ohio State Dr. Min Yin July 21 to see what he thinks. Any thoughts? Thanks
RunThru
in
Advanced Prostate Cancer
3 years ago
Stump the Oncologist!
I am on monotherapy
enzalutamide
and have been for some time. My T is 600+. Enza prohibits the uptake of androgens everywhere in the body, not just the tumor cells, so no T in muscles and elsewhere while it circulates in serum. He noted I had not had a bone density test in several years.
I am on monotherapy
enzalutamide
and have been for some time. My T is 600+. Enza prohibits the uptake of androgens everywhere in the body, not just the tumor cells, so no T in muscles and elsewhere while it circulates in serum. He noted I had not had a bone density test in several years.
tarhoosier
in
Advanced Prostate Cancer
3 years ago
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The C-reactive protein-albumin ratio [CAR]
[u]patients with CAR > 0.5 has significantly shorter CSS than those with CAR ≤ 0.5 in abiraterone (median of 23 vs 49 months ...) and
enzalutamide
(median of 23 vs 41 months[/u] ...)" Quite a big difference. What does "prognostic" mean?
[u]patients with CAR > 0.5 has significantly shorter CSS than those with CAR ≤ 0.5 in abiraterone (median of 23 vs 49 months ...) and
enzalutamide
(median of 23 vs 41 months[/u] ...)" Quite a big difference. What does "prognostic" mean?
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Most likely radiation schedule
Will reevaluate after 6th chemo, but likely course is adding abiraterone or
enzalutamide
, and radiation to prostate. We are both still working and live by our calendars. We can relocate to Rochester, MN and work remotely if necessary but it would be great to plan for possible scenarios.
Will reevaluate after 6th chemo, but likely course is adding abiraterone or
enzalutamide
, and radiation to prostate. We are both still working and live by our calendars. We can relocate to Rochester, MN and work remotely if necessary but it would be great to plan for possible scenarios.
leebeth
in
Advanced Prostate Cancer
3 years ago
Which is better regarding Cognitive and Fatigue Side Effects: Abiratirone + Pred. or Enzalutamide in mCRPC?
) and
enzalutamide
(ENZ) are commonly prescribed for metastatic castration-resistant prostate cancer (mCRPC).
) and
enzalutamide
(ENZ) are commonly prescribed for metastatic castration-resistant prostate cancer (mCRPC).
MateoBeach
in
Advanced Prostate Cancer
3 years ago
Statins and adrenal androgen levels in prostate cancer: A new twist
The clinical relevance of intratumoural androgens in promoting prostate tumour growth is clearly confirmed by the efficacy of potent ligand synthesis and AR inhibitors such as abiraterone and
enzalutamide
.
The clinical relevance of intratumoural androgens in promoting prostate tumour growth is clearly confirmed by the efficacy of potent ligand synthesis and AR inhibitors such as abiraterone and
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Enzalutamide after abiraterone
Has anyone had a good response with
enzalutamide
(Xtandi) after abiraterone? *My father has not been on chemo yet.
Has anyone had a good response with
enzalutamide
(Xtandi) after abiraterone? *My father has not been on chemo yet.
Vsahay
in
Advanced Prostate Cancer
3 years ago
Changing horses, Enzalutamide to Abiraterone(Zytiga)
New activity is likely the old adenocarcinoma which has found a "work around" after 10 plus years of ADT and
Enzalutamide
not working to block AR receptors. So we made a decision to start on Abiraterone/prednisone now while continuing on Lupron. So far tolerating the new drugs and labs are okay.
New activity is likely the old adenocarcinoma which has found a "work around" after 10 plus years of ADT and
Enzalutamide
not working to block AR receptors. So we made a decision to start on Abiraterone/prednisone now while continuing on Lupron. So far tolerating the new drugs and labs are okay.
DenDoc
in
Advanced Prostate Cancer
3 years ago
Hexose-6-phosphate dehydrogenase blockade reverses enzalutamide resistance
New Paper: “Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation” https://stm.sciencemag.org/content/13/595/eabe8226
New Paper: “Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation” https://stm.sciencemag.org/content/13/595/eabe8226
SimonHL
in
Advanced Prostate Cancer
3 years ago
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - ERC -6.15.21
Signaling Inhibitor) ******************************************************** [i]For the purposes of this review, we will focus our discussion on the newer, more effective ARSIs: specifically, the CYP17 inhibitor abiraterone and the 2nd generation AR ligand-binding domain (LBD) antagonists (antiandrogens)
enzalutamide
Signaling Inhibitor) ******************************************************** [i]For the purposes of this review, we will focus our discussion on the newer, more effective ARSIs: specifically, the CYP17 inhibitor abiraterone and the 2nd generation AR ligand-binding domain (LBD) antagonists (antiandrogens)
enzalutamide
cujoe
in
Fight Prostate Cancer
3 years ago
Results of Second Fusion of LU-177
I had my first infusion in Febuary 2021 after
Enzalutamide
(Xtandi) stopped working and PSA increased to 50. My first infusion reduced my PSA to 3.5. My second infusion on 8 April 2021 reduced my PSA to .6.
I had my first infusion in Febuary 2021 after
Enzalutamide
(Xtandi) stopped working and PSA increased to 50. My first infusion reduced my PSA to 3.5. My second infusion on 8 April 2021 reduced my PSA to .6.
topofthemountain
in
Advanced Prostate Cancer
3 years ago
Article: FDA grants 177Lu-PSMA-617 breakthrough designation for mCRPC
The open-label phase 3 VISION trial (NCT03511664) included 831 patients (1179 initially screened) with progressive PSMA-positive mCRPC who received at least 1 novel androgen axis drug (eg,
enzalutamide
[Xtandi] or abiraterone acetate [Zytiga]) and were previously treated with 1 to 2 taxane regimens.
The open-label phase 3 VISION trial (NCT03511664) included 831 patients (1179 initially screened) with progressive PSMA-positive mCRPC who received at least 1 novel androgen axis drug (eg,
enzalutamide
[Xtandi] or abiraterone acetate [Zytiga]) and were previously treated with 1 to 2 taxane regimens.
GregHouston
in
Advanced Prostate Cancer
3 years ago
Combination Treatments for Hormone Sensitive PC (mHSPC): Trusting a Meta-Analysis
Enzalutamide
appeared to have better OS compared with docetaxel in men with low-volume disease, but there was no difference in other comparisons.
Enzalutamide
appeared to have better OS compared with docetaxel in men with low-volume disease, but there was no difference in other comparisons.
MateoBeach
in
Advanced Prostate Cancer
3 years ago
CRPC special-- causes of Enzalutamide resistance, Treatment comparisons in nMCRPC, and Improved OS with Masitinib and Docetaxel
We demonstrate an increased number of BRCA2 alterations post-
enzalutamide
highlighting importance of serial tumor sampling in CRPC.
We demonstrate an increased number of BRCA2 alterations post-
enzalutamide
highlighting importance of serial tumor sampling in CRPC.
NPfisherman
in
Fight Prostate Cancer
3 years ago
Akkermansia
demonstrated A. muciniphila to invoke a multiplicity of health benefits in their hosts and improve the efficacy of checkpoint inhibitor cancer immunotherapies" 2] 2018, Johns Hopkins: This study reported that that [u]
oral
[/u] androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
demonstrated A. muciniphila to invoke a multiplicity of health benefits in their hosts and improve the efficacy of checkpoint inhibitor cancer immunotherapies" 2] 2018, Johns Hopkins: This study reported that that [u]
oral
[/u] androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Radiotherapy - are there any disadvantages?
So, 7 months on
enzalutamide
has passed quickly and I get a phone call out of the blue from the Royal Marsden. "We want you to start targeted radiotherapy on your prostate. Please come in for us to arrange this." My PSA currently hovers around 0.18.
So, 7 months on
enzalutamide
has passed quickly and I get a phone call out of the blue from the Royal Marsden. "We want you to start targeted radiotherapy on your prostate. Please come in for us to arrange this." My PSA currently hovers around 0.18.
londoncyclist48
in
Advanced Prostate Cancer
3 years ago
Immunotherapy Clinical Trial or Olaparib (Lynparza)?
But, if he is put into the control group, he'd receive
enzalutamide
(another ADT drug). 2. Olaparib (Lynparza) - I'm not super convinced of the efficacy of this treatment course.
But, if he is put into the control group, he'd receive
enzalutamide
(another ADT drug). 2. Olaparib (Lynparza) - I'm not super convinced of the efficacy of this treatment course.
PCdaughte
in
Advanced Prostate Cancer
3 years ago
Sartor on BAT and genomic profiling (excerpts)
By the way, one of the important findings from the transformer study is that after the use of testosterone, you can re-sensitize to things like
enzalutamide
, and you can come back with the
enzalutamide
and get a very high response rate. And that is a different subset analysis.
By the way, one of the important findings from the transformer study is that after the use of testosterone, you can re-sensitize to things like
enzalutamide
, and you can come back with the
enzalutamide
and get a very high response rate. And that is a different subset analysis.
cigafred
in
Advanced Prostate Cancer
3 years ago
The same mRNA science that brought us the COVID-19 vaccine is being studied for mCRPCa
., abiraterone or
enzalutamide
, docetaxel, cabazitaxel) or cannot tolerate any of these therapies. These lines of therapy include life-prolonging therapies administered in the metastatic hormone-sensitive setting.”
., abiraterone or
enzalutamide
, docetaxel, cabazitaxel) or cannot tolerate any of these therapies. These lines of therapy include life-prolonging therapies administered in the metastatic hormone-sensitive setting.”
tallguy2
in
Advanced Prostate Cancer
3 years ago
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