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Docetaxel
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Good News-But Do I Belong Here?
Early
docetaxel
probably didn't help any (as has been shown by now in STAMPEDE) but the hope is that the rest of it was worth it. Early treatment this aggressive in my type situation has not been proven efficacious either but my hunch (shared by my MO) is that could be.
Early
docetaxel
probably didn't help any (as has been shown by now in STAMPEDE) but the hope is that the rest of it was worth it. Early treatment this aggressive in my type situation has not been proven efficacious either but my hunch (shared by my MO) is that could be.
London441
in
Advanced Prostate Cancer
2 years ago
Progressing on multiple line, Ac225 next ???
53 yrs male post BSO Diagnosed metatstatic CRPC progressed on abiraterone ,
docetaxel
, cabazetaxel started on enza since aug 21 added Lu-PSMA therapy since Sept 21 (received 3 sessions) Progression on PSMA scan, 2/3 new bone sites, PSA 22.7 (Aug 21) to 43.3 (Mar 22) FDG low burden.
53 yrs male post BSO Diagnosed metatstatic CRPC progressed on abiraterone ,
docetaxel
, cabazetaxel started on enza since aug 21 added Lu-PSMA therapy since Sept 21 (received 3 sessions) Progression on PSMA scan, 2/3 new bone sites, PSA 22.7 (Aug 21) to 43.3 (Mar 22) FDG low burden.
pka21
in
Advanced Prostate Cancer
2 years ago
Docetaxel PSA decreased but new bone mets
I started my therapy in March with ADT +
Docetaxel
every 28/21days. PSA dropped to 13 last month and to 3 last week. I generally feel good and blood tests are good too.
I started my therapy in March with ADT +
Docetaxel
every 28/21days. PSA dropped to 13 last month and to 3 last week. I generally feel good and blood tests are good too.
Rafa2
in
Advanced Prostate Cancer
2 years ago
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'Substandard' Control Arms in Clinical Trials– Practice found common in prostate cancer studies
Thirty-five percent of patients had not received prior
docetaxel
, and 45% of
docetaxel
-pretreated patients had not received prior cabazitaxel -- treatments proven to improve survival in the mCRPC setting.
Thirty-five percent of patients had not received prior
docetaxel
, and 45% of
docetaxel
-pretreated patients had not received prior cabazitaxel -- treatments proven to improve survival in the mCRPC setting.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Boring! (In a good way.)
Spouse21 ended his 10th
docetaxel
infusion over two years ago, which is a very decent result that a lot of men don't experience. Who knows why? We sure don't. He's on the Lupron life sentence and gets an Xgeva shot every three months. Both suck.
Spouse21 ended his 10th
docetaxel
infusion over two years ago, which is a very decent result that a lot of men don't experience. Who knows why? We sure don't. He's on the Lupron life sentence and gets an Xgeva shot every three months. Both suck.
spouse21
in
Advanced Prostate Cancer
2 years ago
Combining Immunotherapy with Docetaxel?
with
docetaxel
. He heard the yet unpublished results are very good. Anyone heard of this or know about this? Thanks very much to all who post.
with
docetaxel
. He heard the yet unpublished results are very good. Anyone heard of this or know about this? Thanks very much to all who post.
CalBear
in
Advanced Prostate Cancer
2 years ago
So what do I do now?
Got through 4
docetaxel
cycles.
Got through 4
docetaxel
cycles.
Miccoman
in
Advanced Prostate Cancer
2 years ago
Supplements now treatment is over
After a combination of Degarelix, 3x Lu-177, 3 x
Docetaxel
my PSA was 98% reduced to 0.19 and scans showed a strong response but some activity remained so I followed up with 3x SBRT to T9 which was still showing ( a much reduced 1.5 SUV) and 20 lots of VMAT radiation to prostate and oelvic area and a
After a combination of Degarelix, 3x Lu-177, 3 x
Docetaxel
my PSA was 98% reduced to 0.19 and scans showed a strong response but some activity remained so I followed up with 3x SBRT to T9 which was still showing ( a much reduced 1.5 SUV) and 20 lots of VMAT radiation to prostate and oelvic area and a
Brysonal
in
Advanced Prostate Cancer
2 years ago
Lutetium-177 PSMA Is a Suitable Option for Post-Docetaxel mCRPC
PSMA PET and FDG PET as predictors of response and prognosis in a randomized phase 2 trial of 177Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic, castration-resistant prostate cancer (mCRPC) progressing after
docetaxel
. (TheraP ANZUP 1603).
PSMA PET and FDG PET as predictors of response and prognosis in a randomized phase 2 trial of 177Lu-PSMA-617 (LuPSMA) versus cabazitaxel in metastatic, castration-resistant prostate cancer (mCRPC) progressing after
docetaxel
. (TheraP ANZUP 1603).
Graham49
in
Advanced Prostate Cancer
2 years ago
Is it possible to have chemo again after radiation?
After 4yrs and several treatment protocols (zytiga,
docetaxel
, xtandi, lu177, cabazitaxel, cabazitaxel+carbo) my husband now has numerous mets on the spine and his pca has traveled to the rectum as well. Nothing worked. PSA kept rising altho his pca emits little PSA.
After 4yrs and several treatment protocols (zytiga,
docetaxel
, xtandi, lu177, cabazitaxel, cabazitaxel+carbo) my husband now has numerous mets on the spine and his pca has traveled to the rectum as well. Nothing worked. PSA kept rising altho his pca emits little PSA.
dvcarola2
in
Advanced Prostate Cancer
2 years ago
First-Line Ribociclib Plus Endocrine Therapy Bests Chemo for Aggressive Breast Cancer
with no prior systemic therapy were recruited; 112 patients were randomly assigned to ribociclib (600 mg daily, three weeks on/one week off) plus an aromatase inhibitor – letrozole or anastrozole – and goserelin and 110 patients were assigned to a physicians’ choice combination chemotherapy regimen (
docetaxel
with no prior systemic therapy were recruited; 112 patients were randomly assigned to ribociclib (600 mg daily, three weeks on/one week off) plus an aromatase inhibitor – letrozole or anastrozole – and goserelin and 110 patients were assigned to a physicians’ choice combination chemotherapy regimen (
docetaxel
Hazelgreen
in
SHARE Metastatic Breast Cancer
1 year ago
PSA now at 15 time to start a treatment but don’t know which drugs.
How many
docetaxel
cycles and is there such a thing as low dose
docetaxel
? Dr Saylor at MGH says time to start lupron Consult at Dana Faber says lupron + abiraterone/prednisone Dr Laccetti at MSK ADT+Abiraterone/prednisone Thank you for your expert opinions
How many
docetaxel
cycles and is there such a thing as low dose
docetaxel
? Dr Saylor at MGH says time to start lupron Consult at Dana Faber says lupron + abiraterone/prednisone Dr Laccetti at MSK ADT+Abiraterone/prednisone Thank you for your expert opinions
KocoPr
in
Prostate Cancer Network
2 years ago
Back to plan B - No longer chasing Lu177
Hubby had been through 10 sessions of
docetaxel
in 2021 where PSA went down to 1.1 (previously 117 at start of chemo). He got a break from it for 2 months, but it climbed back up to 46.8 and had to go back on
docetaxel
again. It didn't work as well as last time - his PSA never got below 24.
Hubby had been through 10 sessions of
docetaxel
in 2021 where PSA went down to 1.1 (previously 117 at start of chemo). He got a break from it for 2 months, but it climbed back up to 46.8 and had to go back on
docetaxel
again. It didn't work as well as last time - his PSA never got below 24.
Yadifan
in
Advanced Prostate Cancer
2 years ago
Soy Isoflavones-Updated 071522
I am stage 4 (diagnosed 09/2016) gleason 9, tx has been
docetaxel
, lupron, xgeva, and zytiga. Please let me know what you guys think. Best, Philip
I am stage 4 (diagnosed 09/2016) gleason 9, tx has been
docetaxel
, lupron, xgeva, and zytiga. Please let me know what you guys think. Best, Philip
pbaldwin
in
Advanced Prostate Cancer
2 years ago
Should i include docetaxel with lupron +darolutamide.
Ive read the trial results but they don’t include ADT+darolutamide with
docetaxel
. Im 64 and healthy with no symptoms.
Ive read the trial results but they don’t include ADT+darolutamide with
docetaxel
. Im 64 and healthy with no symptoms.
KocoPr
in
Advanced Prostate Cancer
2 years ago
Stampede Trial: Arm H
Arm H found significant improvement by adding SBRT/SABR to Primary Prostate gland in addition to Lupron, Abi,
Docetaxel
(Triple ADT) to Oligometastatic Men, or low Metastatic Burden Men. 81% of Men were Alive at 3yrs of all causes vs 73% with Trip ADT alone.
Arm H found significant improvement by adding SBRT/SABR to Primary Prostate gland in addition to Lupron, Abi,
Docetaxel
(Triple ADT) to Oligometastatic Men, or low Metastatic Burden Men. 81% of Men were Alive at 3yrs of all causes vs 73% with Trip ADT alone.
Spyder54
in
Advanced Prostate Cancer
2 years ago
Docetaxel didn't work, what's next?
Completed 7 cycles of
chemotherapy (Feb 2022 - June 2022). Rising PSA and imaging had shown progression with intra-abdominal disease, and new lung involvement. Switched to
cabazitaxel
and has completed two cycles, needs to complete 8 more. Isn't tolerating it well.
Completed 7 cycles of
chemotherapy (Feb 2022 - June 2022). Rising PSA and imaging had shown progression with intra-abdominal disease, and new lung involvement. Switched to
cabazitaxel
and has completed two cycles, needs to complete 8 more. Isn't tolerating it well.
anscombethomson
in
Advanced Prostate Cancer
2 years ago
Wondering which arm of STAMPEDE dictated my 18 to 16 month ADT plus Zytiga treatment plan ?
The STAMPEDE article posted by today by Spyder includes
Docetaxel
( which I’m not taking ) in the trial . Does anyone know which arm of Stampede dictates my treatment plan ?
The STAMPEDE article posted by today by Spyder includes
Docetaxel
( which I’m not taking ) in the trial . Does anyone know which arm of Stampede dictates my treatment plan ?
PBnative
in
Advanced Prostate Cancer
2 years ago
DOCETAXEL FATIGUE
I have had 2 rounds of somewhat reduced dose
docetaxel
. PSA down after the first round which is terrific, but I am trying to wrap my head around the fatigue I am experiencing.
I have had 2 rounds of somewhat reduced dose
docetaxel
. PSA down after the first round which is terrific, but I am trying to wrap my head around the fatigue I am experiencing.
Arthur479
in
Advanced Prostate Cancer
2 years ago
Looking for thoughts on next treatment after Docetaxel
. - Started on
Docetaxel
in Fall 2021 for 10 cycles. - PSA dropped to 10 but the mets had a very slight increase. So what's next: more chemo, Radium 223 (I have no pain), PARP inhibitor, or something else. Thanks for your thoughts.
. - Started on
Docetaxel
in Fall 2021 for 10 cycles. - PSA dropped to 10 but the mets had a very slight increase. So what's next: more chemo, Radium 223 (I have no pain), PARP inhibitor, or something else. Thanks for your thoughts.
davebliz
in
Advanced Prostate Cancer
2 years ago
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