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Darolutamide failing after 2 years. Any success if I switch to Xandi or Zytiga or do I need to move to Pluvicto.
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Longterm101
in
Advanced Prostate Cancer
6 months ago
Blood results help
Hi I have had blood test tsh is one (range 0.4 to 5) and T4 is 14 ( range is 9 to 19). Also had an ultrasound which showed altered echotexture but no enlargement of thyroid. Are these results OK? Have symptoms of underactive thyroid but results all in range. Thanks
Hi I have had blood test tsh is one (range 0.4 to 5) and T4 is 14 ( range is 9 to 19). Also had an ultrasound which showed altered echotexture but no enlargement of thyroid. Are these results OK? Have symptoms of underactive thyroid but results all in range. Thanks
Lolly2564
in
Thyroid UK
2 months ago
Other blood results
I now have more results Serum folate 14.3 (3.1-17.5) Ferritin 138 (13-150) Iron 14 (5-28) B12 280 (200-940) Since they are in the range ‘everything is normal’! The coeliac one was clear so I can now try gluten free for 3 months to see if it makes any changes. But I am still tired, muscle aches
I now have more results Serum folate 14.3 (3.1-17.5) Ferritin 138 (13-150) Iron 14 (5-28) B12 280 (200-940) Since they are in the range ‘everything is normal’! The coeliac one was clear so I can now try gluten free for 3 months to see if it makes any changes. But I am still tired, muscle aches
Purple450
in
Thyroid UK
2 months ago
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hi everyone l joined this group today was wondering could l get any advice, am 38 been recently diagnosed with underactive thyroid l am currently on 100mg of Lev tablets but l still feel tired l have put on so much weigh in past few years and didn’t know what was causing it, I have bought the semuglutide
hi everyone l joined this group today was wondering could l get any advice, am 38 been recently diagnosed with underactive thyroid l am currently on 100mg of Lev tablets but l still feel tired l have put on so much weigh in past few years and didn’t know what was causing it, I have bought the semuglutide
Preciouspearl
in
Thyroid UK
2 months ago
Lupus re-diagnosis UCTD
Hello All, so when I last posted I had been to the rheumatologist Prof X and told my bloods were not suggestive of lupus but he did not suggest want condition could be the underlying cause of my symptoms. This morning he chose not to see me, instead I saw a very nice female doctor in clinical research
Hello All, so when I last posted I had been to the rheumatologist Prof X and told my bloods were not suggestive of lupus but he did not suggest want condition could be the underlying cause of my symptoms. This morning he chose not to see me, instead I saw a very nice female doctor in clinical research
KeepingUpBeat
in
LUPUS UK
2 months ago
Overall Survival With [177]Lu-PSMA-617 vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
Magnus1964
in
Advanced Prostate Cancer
6 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
jackwfrench
in
Advanced Prostate Cancer
6 months ago
Parkinson’s and vagal nerve stimulation, promising human studies.
RESULTS: PD patients showed instable gait with insufficient range of motion during usual walking. [u]
Active taVNS improved gait characteristics including step length, stride velocity, stride length, and step length variability compared with sham taVNS after completion of the 7-day therapy.
[/u]
RESULTS: PD patients showed instable gait with insufficient range of motion during usual walking. [u]
Active taVNS improved gait characteristics including step length, stride velocity, stride length, and step length variability compared with sham taVNS after completion of the 7-day therapy.
[/u]
House2
in
Cure Parkinson's
6 months ago
Study: Depression is largely prevalent, but undiagnosed in SLEResearchers in Pakistan surveyed 40 people with SLE using PHQ-9 scale
Depression is highly prevalent among people with systemic lupus erythematosus (SLE), but often goes undiagnosed, according to a single center study in Pakistan. The “treatment of depression is a vital component in the management of these patients and should be offered where appropriate,” the researchers
Depression is highly prevalent among people with systemic lupus erythematosus (SLE), but often goes undiagnosed, according to a single center study in Pakistan. The “treatment of depression is a vital component in the management of these patients and should be offered where appropriate,” the researchers
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 months ago
I wonder how many of us have this gene snip?It seems responsible for some autoimmune Thyroid disease and is quite rare
I have my nebula genomics results and this snip in particular seems relevant . Does anyone else have their results? Snip rs2476601 it says in snpedia.com that it is bad to have an A and very rare to have 2 AA Can cause lots of other autoimmune diseases too Best wishes Manjushri
I have my nebula genomics results and this snip in particular seems relevant . Does anyone else have their results? Snip rs2476601 it says in snpedia.com that it is bad to have an A and very rare to have 2 AA Can cause lots of other autoimmune diseases too Best wishes Manjushri
Manjushri
in
Thyroid UK
2 months ago
T3 when to take it
have been put on a T3 trial by a private doctor who specialises in thyroid conditions, just wondered what time of day morning and evening is best to take it, as have been told to take it twice a day. Been on thyroid medication for over 70 years. For a underactive thyroid. As members say the thyroid
have been put on a T3 trial by a private doctor who specialises in thyroid conditions, just wondered what time of day morning and evening is best to take it, as have been told to take it twice a day. Been on thyroid medication for over 70 years. For a underactive thyroid. As members say the thyroid
elwins
in
Thyroid UK
2 months ago
Does anyone with LUPUS get reoccurring Shingles/ Herpes Zoster infections?
So I am waiting to be diagnosed with Lupus/ Mix Connective Tissue Disease. I have a lot of the symptoms for lupus like the face rash, other rashes on my body. Severing from fatigue, mouth ulcers really bad migraines. My body gets swollen and holds a lot of fluid. Joint pain as well as stomach issues.
So I am waiting to be diagnosed with Lupus/ Mix Connective Tissue Disease. I have a lot of the symptoms for lupus like the face rash, other rashes on my body. Severing from fatigue, mouth ulcers really bad migraines. My body gets swollen and holds a lot of fluid. Joint pain as well as stomach issues.
Severancered9
in
LUPUS UK
2 months ago
Is Baclofen part of asthma treatment?
I was taken off Montelukast by my Asthma specialist after more than twenty years. Baclofen was given but I had to stop taking it after two weeks because my cough didn't get better. My GP asked me to stop. I couldn't get in touch with my specialist. Should I restart the Baclofen?
I was taken off Montelukast by my Asthma specialist after more than twenty years. Baclofen was given but I had to stop taking it after two weeks because my cough didn't get better. My GP asked me to stop. I couldn't get in touch with my specialist. Should I restart the Baclofen?
Ossing
in
Asthma Community Forum
6 months ago
Lyme disease
Reply to Steve n. Yes have Lyme . Diagnosed with ME so sadly no treatment. Very interested to hear about new treatment.
Reply to Steve n. Yes have Lyme . Diagnosed with ME so sadly no treatment. Very interested to hear about new treatment.
Shelley1234567
in
Pernicious Anaemia Society
6 months ago
Could thyroid be causing the issues ?
I have enclosed my daughters ( age 22 ) last thyroid result panel. Her TSH in June last year was over 6 then swung down to under 2 in September but is on the rise again. Her T3/ T4 are always just above minimum. Her father has Hashimoto’s as did her Grandfather and so does her male cousin. Grandad unfortunately
I have enclosed my daughters ( age 22 ) last thyroid result panel. Her TSH in June last year was over 6 then swung down to under 2 in September but is on the rise again. Her T3/ T4 are always just above minimum. Her father has Hashimoto’s as did her Grandfather and so does her male cousin. Grandad unfortunately
BigMamma17
in
Thyroid UK
2 months ago
ACID REFLUX-ARTHRITIS
I rarely get time to read or comment on posts here ...but this morning I have and have been struck by the number of us who suffer from Acid Reflux ... Is this a chicken/egg situation ? do we get acid reflux as another sideline to Arthritis or is it caused by medication ? those of us with reflux issues
I rarely get time to read or comment on posts here ...but this morning I have and have been struck by the number of us who suffer from Acid Reflux ... Is this a chicken/egg situation ? do we get acid reflux as another sideline to Arthritis or is it caused by medication ? those of us with reflux issues
RUSTY750
in
NRAS
2 months ago
Underactive thyroid
Hi, my thyroid levels have been up and down recently. I've been on 125mcg and felt fine until the GP decided, after a blood test, to lower the dose. The dosage I need isn't available so I'm now on 100mcg for 5 days and then 112mcg for 2 days. Is this an ok thing to do? Thanks.
Hi, my thyroid levels have been up and down recently. I've been on 125mcg and felt fine until the GP decided, after a blood test, to lower the dose. The dosage I need isn't available so I'm now on 100mcg for 5 days and then 112mcg for 2 days. Is this an ok thing to do? Thanks.
Hidden
in
Thyroid UK
2 months ago
Three Distinct MS Subtypes Identified
[i]I'm so sorry. I sent a bad link. Hopefully this one will work better.[/i]
MDedge/Neurology 09 Apr 2024
https://www.mdedge.com/neurology/article/268641/multiple-sclerosis/three-distinct-ms-subtypes-identified
[i]I'm so sorry. I sent a bad link. Hopefully this one will work better.[/i]
MDedge/Neurology 09 Apr 2024
https://www.mdedge.com/neurology/article/268641/multiple-sclerosis/three-distinct-ms-subtypes-identified
BettysMom
in
My MSAA Community
2 months ago
Prostate cancer
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
Yuncoinc7148
in
Fight Prostate Cancer
6 months ago
Liver Biopsy report, can anyone interpret?
Hello all, got my cirrhosis dx in march from a biopsy, however I have the full report, is there anything else of note from it other than I have cirrhosis from fat in the liver? The biopsy followed a high fibroscan read of 30.7kPa. Thank you Specimen: Liver, very high fibroscan reading ?cirrhosis
Hello all, got my cirrhosis dx in march from a biopsy, however I have the full report, is there anything else of note from it other than I have cirrhosis from fat in the liver? The biopsy followed a high fibroscan read of 30.7kPa. Thank you Specimen: Liver, very high fibroscan reading ?cirrhosis
aranshaw
in
British Liver Trust
6 months ago
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