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Toward safer steroids: Scientists devise process for making precision anti-inflammatory medicines.
A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named “ligand class analysis.” Their process enabled them to
A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named “ligand class analysis.” Their process enabled them to
2greys
in
Lung Conditions Community Forum
4 years ago
Struggling with Covid and asthma.
Update: 02/02/21 Hubby and I finally well enough to leave hospital to continue our recovery. It's going to be a long haul as we both have on going issues due to Covid. Thank you for the well wishes. Home at last after 10 days in hospital. Can't fault the care we received throughout. Update: 29/01/21
Update: 02/02/21 Hubby and I finally well enough to leave hospital to continue our recovery. It's going to be a long haul as we both have on going issues due to Covid. Thank you for the well wishes. Home at last after 10 days in hospital. Can't fault the care we received throughout. Update: 29/01/21
redstar9
in
Asthma Community Forum
4 years ago
Genital Lichen Sclerosus
Hi everybody, I was diagnosed with BXO a few days ago. I had always had phimosis (full retraction when flaccid; none when erect) but in last 5 months my phimosis had closed completely and I developed scarring and discolouration on the foreskin. At the moment, my foreskin is so tight that it is uncomfortable
Hi everybody, I was diagnosed with BXO a few days ago. I had always had phimosis (full retraction when flaccid; none when erect) but in last 5 months my phimosis had closed completely and I developed scarring and discolouration on the foreskin. At the moment, my foreskin is so tight that it is uncomfortable
Cosma
in
Men's Health Forum (Penis Health)
4 years ago
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Dad/Heart Risk with ADT. Almost 3 years in PSA good.
Hi all! Checking in, now almost 3 years now since diagnosis for my dad. PSA17, G9. Lupron and Zytiga (4) plus prednisone (5mg) daily since mid 2018. 28 sessions of radiation also in early 2019. I'm worried about cardiovascular effects and weight gain. His belly is very big now. He has changed a lot in
Hi all! Checking in, now almost 3 years now since diagnosis for my dad. PSA17, G9. Lupron and Zytiga (4) plus prednisone (5mg) daily since mid 2018. 28 sessions of radiation also in early 2019. I'm worried about cardiovascular effects and weight gain. His belly is very big now. He has changed a lot in
DaughterOnAMission
in
Advanced Prostate Cancer
4 years ago
Quest for Lu 177 succeeded
I am writing this waiting for my radiation readings to go down so I can go back to our flat here in Windsor. My first dose of Lu 177 is circulating through my system. Amazing it is jus 8 mL of “medication”. For those of you thinking about this therapy a PSMA PET CT scan will have to be done first
I am writing this waiting for my radiation readings to go down so I can go back to our flat here in Windsor. My first dose of Lu 177 is circulating through my system. Amazing it is jus 8 mL of “medication”. For those of you thinking about this therapy a PSMA PET CT scan will have to be done first
Cleodman
in
Advanced Prostate Cancer
4 years ago
Dexamethasone.
Hi,does anyone else use dexamethasone drops for life after having trab surgery as I have been prescribed them for life now after surgery.?
Hi,does anyone else use dexamethasone drops for life after having trab surgery as I have been prescribed them for life now after surgery.?
chris4146
in
Glaucoma UK
4 years ago
Post Covid
Good morning all . It has been almost 3 weeks since I caught Covid and ended up in hospital. I’m almost feeling human again but much of it is a case of having to get on with it . I’ve lost loads of weight, have no energy and I’ve gone off my life saving cups of tea . I upped my Prednisilone from 3mg
Good morning all . It has been almost 3 weeks since I caught Covid and ended up in hospital. I’m almost feeling human again but much of it is a case of having to get on with it . I’ve lost loads of weight, have no energy and I’ve gone off my life saving cups of tea . I upped my Prednisilone from 3mg
Greensleeves
in
PMRGCAuk
4 years ago
What are Tocilizumab and Sarilumab treatments for COVID?
The REMPA-CPAP Clinical trial results show that the drugs reduced the risk of death by 24% for critically ill patients and reduced the time spent in intensive care by up to 10 days. In light of these results, the UK government has said that supplies of tocilizumab are already available in hospitals
The REMPA-CPAP Clinical trial results show that the drugs reduced the risk of death by 24% for critically ill patients and reduced the time spent in intensive care by up to 10 days. In light of these results, the UK government has said that supplies of tocilizumab are already available in hospitals
Jm954
Administrator
in
CLL Support
4 years ago
Coronavirus disease (COVID-19) advice for the public: Mythbusters
FACT: Vitamin and mineral supplements cannot cure COVID-19 Micronutrients, such as vitamins D and C and zinc, are critical for a well-functioning immune system and play a vital role in promoting health and nutritional well-being. There is currently no guidance on the use of micronutrient supplements
FACT: Vitamin and mineral supplements cannot cure COVID-19 Micronutrients, such as vitamins D and C and zinc, are critical for a well-functioning immune system and play a vital role in promoting health and nutritional well-being. There is currently no guidance on the use of micronutrient supplements
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
4 years ago
Dexamethasone Shortage!
My regular pharmacy could not supply my dex refill. They said there was a manufacturers shortage. I finally found a CVS store that had stock to fill a 30 day script. My MO concurred with me that it’s due to dex being used in large doses to mitigate Covid symptoms.
My regular pharmacy could not supply my dex refill. They said there was a manufacturers shortage. I finally found a CVS store that had stock to fill a 30 day script. My MO concurred with me that it’s due to dex being used in large doses to mitigate Covid symptoms.
6357axbz
in
Advanced Prostate Cancer
4 years ago
Suggestions on next step of therapy
Looking for some guidance on where to go from here as is it appears I'm on my way to castrate resistance. Diagnosed in March 2019 with T4N0M1b HSPC. Started Lupron then, added Zytiga/Prednisone in May 2019. Due to also having progressive MS we opted for the Zytiga approach as opposed to docetaxel. My
Looking for some guidance on where to go from here as is it appears I'm on my way to castrate resistance. Diagnosed in March 2019 with T4N0M1b HSPC. Started Lupron then, added Zytiga/Prednisone in May 2019. Due to also having progressive MS we opted for the Zytiga approach as opposed to docetaxel. My
Kentucky1
in
Advanced Prostate Cancer
4 years ago
Help with Non Hodkin’s Lymphoma
Hello I’m new here. I have just started a new regimen of treatment for Follicular Lymphoma. The first regimen R-CHOP got rid of the lump in my groin but unfortunately the lumps in my chest and neck resisted the treatment. My consultant told me this is not a good sign and he is concerned. They are communicating
Hello I’m new here. I have just started a new regimen of treatment for Follicular Lymphoma. The first regimen R-CHOP got rid of the lump in my groin but unfortunately the lumps in my chest and neck resisted the treatment. My consultant told me this is not a good sign and he is concerned. They are communicating
Charlie120920
in
Non Hodgkin's Lymphoma Friends
4 years ago
Hypothyroid, coeliac, PMR - my journey to 0 pred
Diagnosed with PMR in 2017 and after a few months of not taking pred, I succumbed and my aches and pains mostly vanished. I was working in a high pressure environment then and was luckily able to keep working and attend my Pilates classes all the way through apart from a 6 week period during the first
Diagnosed with PMR in 2017 and after a few months of not taking pred, I succumbed and my aches and pains mostly vanished. I was working in a high pressure environment then and was luckily able to keep working and attend my Pilates classes all the way through apart from a 6 week period during the first
Casia
in
PMRGCAuk
4 years ago
Clodronate. And how to deal with emerging Radiation Induced lumbo-sacral plexopathy?
First the personal and then the science: I completed PLN RT to left hemipelvis about a year ago (58Gy in 28 fractions with boost to two PSMA avid nodes. Thee months or so after the RT I developed left sacro-iliac joint and adjacent muscular pain. Bothersome but did not impair my functioning. I had L-S
First the personal and then the science: I completed PLN RT to left hemipelvis about a year ago (58Gy in 28 fractions with boost to two PSMA avid nodes. Thee months or so after the RT I developed left sacro-iliac joint and adjacent muscular pain. Bothersome but did not impair my functioning. I had L-S
MateoBeach
in
Advanced Prostate Cancer
4 years ago
Zytiga and dexamethasone
My husband has been on zytiga and dexamethasone since mid August. Lately he has become much angrier and some weight gain. Also it seems like his feet aren’t working as well. Has anyone else seen these symptoms with this drug combination? Thank you in advance.
My husband has been on zytiga and dexamethasone since mid August. Lately he has become much angrier and some weight gain. Also it seems like his feet aren’t working as well. Has anyone else seen these symptoms with this drug combination? Thank you in advance.
Cynthgob
in
Advanced Prostate Cancer
4 years ago
Dexamethasone instead of Prednisone for PMR????
Hi All! Been through some things with esophagus - had dilation and polyps removed. Acid reflux is bad and gastro thinks prednisone has had an impact after 2 years. No enteric pred in US and doc doesn't thiink putting it in a capsule is a good idea. I am down to 3.5 mg - occasional 5 if I flare and
Hi All! Been through some things with esophagus - had dilation and polyps removed. Acid reflux is bad and gastro thinks prednisone has had an impact after 2 years. No enteric pred in US and doc doesn't thiink putting it in a capsule is a good idea. I am down to 3.5 mg - occasional 5 if I flare and
bluegirl7
in
PMRGCAuk
4 years ago
Happy Last Chemo Day!
My wonderful, loving husband, Steve, will have his final Docetaxel treatment today, Dec. 3rd. Yay! As those of you who have been down the chemo road know, it hasn't been a picnic so he's happy to see this day finally arrive. We read all the chemo tips on this site and others before he started treatment
My wonderful, loving husband, Steve, will have his final Docetaxel treatment today, Dec. 3rd. Yay! As those of you who have been down the chemo road know, it hasn't been a picnic so he's happy to see this day finally arrive. We read all the chemo tips on this site and others before he started treatment
Avanat
in
Advanced Prostate Cancer
4 years ago
DOUBLE CONDTIONS TREATED WITHPRED
Is anyone on this site who has PMR and ITP a conditon , autoimmune condition that lower platelets that control bleeding in our body can cause one to bleed. Both are treated with prednisone. My platelets dropped early this week down to 25 k. Normal is 15k and above. I have been put on a 4 day dose
Is anyone on this site who has PMR and ITP a conditon , autoimmune condition that lower platelets that control bleeding in our body can cause one to bleed. Both are treated with prednisone. My platelets dropped early this week down to 25 k. Normal is 15k and above. I have been put on a 4 day dose
sandydame
in
PMRGCAuk
4 years ago
Bladder problems??
After 3 months on Zytiga and Prednisone with no drop in a climbing PSA ( 6.4 in 12/19 to 20.1 on 11/14/20)we elected to try Dexamethasone with the Zytiga. I was on Xtandi for 3 yrs prior. But I noticed my evening bladder leakage problems got much worse. I usually just use a Maximum Depends Guard at night
After 3 months on Zytiga and Prednisone with no drop in a climbing PSA ( 6.4 in 12/19 to 20.1 on 11/14/20)we elected to try Dexamethasone with the Zytiga. I was on Xtandi for 3 yrs prior. But I noticed my evening bladder leakage problems got much worse. I usually just use a Maximum Depends Guard at night
docbulldog
in
Advanced Prostate Cancer
4 years ago
Why am I being given a dexamethasone suppression test?
After my previous blood test (stated on my last post) the doctor said that I was not anaemic, even though I have all the symptoms and have very low iron, and therefore won’t prescribe me with iron. I explained to the doctor that I was diagnosed with anxiety a year ago and that would be the main reason
After my previous blood test (stated on my last post) the doctor said that I was not anaemic, even though I have all the symptoms and have very low iron, and therefore won’t prescribe me with iron. I explained to the doctor that I was diagnosed with anxiety a year ago and that would be the main reason
droferwyziad
in
Women's Health
4 years ago
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