just found out I my cancer is brca-2 positive. Ok so I qualify for PARPs but my overall prognosis is worse. Any feedback out there?
brca-2 advanced prostate cancer - Fight Prostate Ca...
brca-2 advanced prostate cancer
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Nowhereman9
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Suggest talking to Denmeade.
clinicaltrials.gov/ct2/show...
Link to a trial... Maybe explain why the possible use of Denmeade? Curious...
Thank you
Sure. Denmeade is the chief investigator for most BAT trials. I've contacted Schweizer and he won't reply to me unless I am a patient at his hospital. Denmeade replies and has asked MOs to contact him if they have questions about BAT.
Olaparib, like Indomethacin, is an AKR1C3 inhibitor [go.drugbank.com/polypeptide...]. AKR1C3 plays an important role in resistance to second-generation antiandrogens, so Olaparib would be a strategy to overcome treatment resistance.
Sorry. I just read your bio and see that you're castration sensitive. Denmeade might not be able to help.
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