Experiences with

Anal fistula

Also last December I had a surgery for a small anal fistula. It healed well, but I think it has returned, so Friday morning I sent an email ago my dr. At the University of Chicago and now I have an appointment on November 11th with the colorectal surgeon that worked on me last December.

Doctor thinks it may be anal fissures or fistula.

Also last December I had a surgery for a small anal fistula. It healed well, but I think it has returned, so Friday morning I sent an email ago my dr. At the University of Chicago and now I have an appointment on November 11th with the colorectal surgeon that worked on me last December.

Promising approach for multiple tumors (even if in its early stage). RPT04402 is a first-in-class molecular glue that selectively reactivates PP2A, a tumor suppressor enzyme crucial for regulating cell growth. By restoring PP2A activity, this therapy suppresses oncogenic pathways, offering a novel

I am in my 60, was diagnosed with stage 2 prostate cancer, i am going Through hell with biopsy and markers procedure, each times I got bad infection, the last procedure I was hospitalized for a week, send home with midline to have ertapenem antibiotic administer for 14 days! I am considering ivermectin

I would have thought methionine was both too ubiquitous and too important for its restriction to be a valid PCa treatment. "During the time the patient was on methionine restriction alone, effected by a low-methionine diet and o-rMETase, the metastatic prostate cancer did not progress. " https://

Because sometimes it's nice to know the actual outcomes in day to day clinical practice. A retrospective real-world study analyzed the effectiveness of apalutamide (APA) combined with androgen-deprivation therapy (ADT) as a first-line treatment for metastatic hormone-sensitive prostate cancer (mHSPC

The WOMBAT Trial (Working Out M0 Bipolar Androgen Therapy) investigates the efficacy of bipolar androgen therapy (BAT) in extending metastasis-free survival for patients with M0 castration-resistant prostate cancer (CRPC) experiencing rising PSA levels on darolutamide, without visible metastases. This

KPG-121 is an experimental cereblon modulator aimed at metastatic castration-resistant prostate cancer (mCRPC). Early research shows it binds more strongly than lenalidomide to a key immune-regulating protein, potentially boosting anti-cancer effects. In a Phase 1 study of 16 mCRPC patients already taking

Has anyone had an MRI proctogram or similar? I've had ibs for 28 years now and tried so many things to help. Haven't had much help thru the nhs. I now suffer from additional even more difficult to deal with issues in that I get urgency to pass stool, tiny flecks of stool, small stool, frequent toilet

Hi, I have tried gtn and diltiazem creams for a chronic fissure which did not work, has anyone here had laser treatment for a fissure?

Repurposing existing drugs, such as rifaximin, can accelerate the development of new treatments because their safety profiles are already established. A recent study screened 3,800 FDA-approved drugs and identified rifaximin as a promising lead compound for PIM-1 inhibition. The potential of rifaximin

A Phase 3 trial is recruiting 675 patients to be randomized to Xaluritamig versus cabazitaxel or an AR switch, aiming to establish its superiority as a second-line treatment. Xaluritamig is a STEAP1-targeted T-cell engager being developed for metastatic castration-resistant prostate cancer (mCRPC).

Happy Christmas to all you wonderful people Where do I begin. It was three months ago I started having symptoms both intertrigo and Diverticulitis. Intertrigo had been there a while earlier, but then the Diverticulitis came. 3 days normal, one day went nuts...constipation, followed hours later

My daughter had a diagnostic lap in august and was told there wasn't any endo but she might have adenomyosis. My daughter had noticed a peri anal lump which didn't mention at the time because she thought it was a pile. She has been managing her menstrual symptoms with desogestrel. she has since been

It's worth checking! https://reporter.nih.gov/project-details/10695499

With all the caveats of an observational study, even if the publisher is highly regarded... A study in JBMR plus found that bone-modifying agents like bisphosphonates and denosumab are linked to improved overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). The

Exciting progress... - https://www.urologytimes.com/view/janx007-demonstrates-encouraging-clinical-activity-in-mcrpc Key takeaways... JANX007 showed promising anti-tumor activity in mCRPC patients, with significant PSA declines and disease control rates observed. Two once-weekly dosing regimens

So i was diagnosed with lgsoc in oct and told its stage 4 . I have been told its quite rare and chemo wont work. Ive had cytroreductive surgery last week and am waiting on my follow up app and to be placed on hormone therapy to stop it growing. Is there anyone who is in the same position and can help

A statistical method, Matching-Adjusted Indirect Comparison (MAIC), has been used to evaluate the effectiveness of different PARP inhibitor combinations for treating metastatic castration-resistant prostate cancer (mCRPC). The study, published on Nature, found that a combination of talazoparib and