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Abiraterone
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Squalene Monooxygenase
"Furthermore, SQLE was essential for proliferation of AR-positive PCa cell lines, including
abiraterone
or enzalutamide resistant derivatives, and blocked transactivation of the AR pathway. ...
"Furthermore, SQLE was essential for proliferation of AR-positive PCa cell lines, including
abiraterone
or enzalutamide resistant derivatives, and blocked transactivation of the AR pathway. ...
pjoshea13
in
Fight Prostate Cancer
1 year ago
How content should I be with my current treatment đ€·
The dust seems to have settled into my current treatment of Lupron,
Abiraterone
, and Prednisone. And I have to admit I'm enjoying riding that path quietly for a while. On the other hand I'm still confused about some things I've brought to my MO and RO.
The dust seems to have settled into my current treatment of Lupron,
Abiraterone
, and Prednisone. And I have to admit I'm enjoying riding that path quietly for a while. On the other hand I'm still confused about some things I've brought to my MO and RO.
Lewellen
in
Advanced Prostate Cancer
2 years ago
Approximately how long can I get with abiraterone plus Zoladex.
(Chemotherapy and radiation treatments as well at diagnosis) Now I am CRPC and have added
abiraterone
. Approximately how long can I get with this combination. When this fails what can I expect. I know I had increased bone pain before the addition of the
abiraterone
.
(Chemotherapy and radiation treatments as well at diagnosis) Now I am CRPC and have added
abiraterone
. Approximately how long can I get with this combination. When this fails what can I expect. I know I had increased bone pain before the addition of the
abiraterone
.
Islandboy2021
in
Advanced Prostate Cancer
2 years ago
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Should my dad continue docetaxel? He seems weakening so much.
We returned to 4th docetaxel and start to add
abiraterone
but again after 2 weeks he got infection and we go into hospital treating again with antibiotic. We only able to take
abiraterone
for 10 days only.
We returned to 4th docetaxel and start to add
abiraterone
but again after 2 weeks he got infection and we go into hospital treating again with antibiotic. We only able to take
abiraterone
for 10 days only.
leechi
in
Advanced Prostate Cancer
2 years ago
Michael T Schweizer & BAT [Bipolar Androgen Therapy
The FDA certainly thought so: "
Abiraterone
acetate was approved by the United States Food and Drug Administration on 28 April 2011 for mCRPC.Â
The FDA certainly thought so: "
Abiraterone
acetate was approved by the United States Food and Drug Administration on 28 April 2011 for mCRPC.Â
pca2004
in
Fight Prostate Cancer
2 years ago
When should you start taking Bisphosphonates, or bone strengthening medications.
I have been on continuous ADT since 2017 plus chemo and now
Abiraterone
with prednisone. The last year I have increased back and rib pain. The pain follows after I lift any heavy objects and usually at night when lying in bed. I defiantly have lost a lot of strength as well.
I have been on continuous ADT since 2017 plus chemo and now
Abiraterone
with prednisone. The last year I have increased back and rib pain. The pain follows after I lift any heavy objects and usually at night when lying in bed. I defiantly have lost a lot of strength as well.
Islandboy2021
in
Advanced Prostate Cancer
2 years ago
Duration of ADT needed with salvage radiation
New data from the "Formula 509" trial shows that hormone intensification with adjuvant apalutamide+
abiraterone
+ADT for just 6 months with salvage radiation therapy (SRT) may be all that's needed: https://www.prostatecancer.news/2023/02/duration-of-adt-needed-with-salvage.html
New data from the "Formula 509" trial shows that hormone intensification with adjuvant apalutamide+
abiraterone
+ADT for just 6 months with salvage radiation therapy (SRT) may be all that's needed: https://www.prostatecancer.news/2023/02/duration-of-adt-needed-with-salvage.html
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Should our RO's be doing HDR for Gleason 9?
And, does the Casodex/Lupron +
Abiraterone
(Zytiga) for 2 yrs + 8 weeks of EBRT sound like "enough" treatment for such an aggressive PCa?? Thanks for your help/guidance, I appreciate it.
And, does the Casodex/Lupron +
Abiraterone
(Zytiga) for 2 yrs + 8 weeks of EBRT sound like "enough" treatment for such an aggressive PCa?? Thanks for your help/guidance, I appreciate it.
Adendino
in
Advanced Prostate Cancer
2 years ago
Get a bone density test if you have PC and are taking Abiraterone etc
I'm on 5 months of ADT (Firmagon first, RT with Lupron, then after RT added
Abiraterone
plus Prednisone.) GLTA
I'm on 5 months of ADT (Firmagon first, RT with Lupron, then after RT added
Abiraterone
plus Prednisone.) GLTA
Derf4223
in
Advanced Prostate Cancer
2 years ago
ï»żLeftover prostate cancer drugs
I would like to help out anyone that has a financial need and has been prescribed
abiraterone
. This is expensive for some people.
I would like to help out anyone that has a financial need and has been prescribed
abiraterone
. This is expensive for some people.
Grumpyswife
in
Advanced Prostate Cancer
2 years ago
Father, 55yrs, diagnosed with prostate cancer
He is also taking
Abiraterone
(Zytiga)1000mg and prednisolone 10mg. Triplet therapy it said. PSA initial diagnosis -380 15days after ADT done and before starting chemo , PSA was 36. And after 3 cycles of chemo it was 9.
He is also taking
Abiraterone
(Zytiga)1000mg and prednisolone 10mg. Triplet therapy it said. PSA initial diagnosis -380 15days after ADT done and before starting chemo , PSA was 36. And after 3 cycles of chemo it was 9.
Helllfire
in
Advanced Prostate Cancer
2 years ago
test Enzalutamide or Lu 177 for the first line therapy?
My father PSA is 157 after 8 sessions of Docetaxel with 150 mg dose and 2 months
Abiraterone
after chemo. His health is not in a good way, anemia, loss of appetite, nausea and neuropathy.
My father PSA is 157 after 8 sessions of Docetaxel with 150 mg dose and 2 months
Abiraterone
after chemo. His health is not in a good way, anemia, loss of appetite, nausea and neuropathy.
Samani
in
Advanced Prostate Cancer
2 years ago
Hoping for the best
I am now on
Abiraterone
and prednisone for two years. I recently read a post that said that if my PSA was undetectable it meant that the cancer cell had died or were in the process of dying. Is this correct?
I am now on
Abiraterone
and prednisone for two years. I recently read a post that said that if my PSA was undetectable it meant that the cancer cell had died or were in the process of dying. Is this correct?
Hidden
in
Advanced Prostate Cancer
2 years ago
PSA rising - follow-up, now falling again
Special thanks to Tall Allen and Pickelballplayer for helping me understand that it was my
Abiraterone
dosage that was most likely to be the cause. I started taking 500 mg on empty stomach and added125 mg every week, now at 750mg .
Special thanks to Tall Allen and Pickelballplayer for helping me understand that it was my
Abiraterone
dosage that was most likely to be the cause. I started taking 500 mg on empty stomach and added125 mg every week, now at 750mg .
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Lu-177 PNT2002 SPLASH trial
The randomized study (32 weeks) will have arm A and arm B (
abiraterone
or enzalutamide) with crossover eligibility. I am concerned if I get assigned to arm B and moving the possible treatment well too late down the road if I change as requested from
Abiraterone
to Enzalutamide.
The randomized study (32 weeks) will have arm A and arm B (
abiraterone
or enzalutamide) with crossover eligibility. I am concerned if I get assigned to arm B and moving the possible treatment well too late down the road if I change as requested from
Abiraterone
to Enzalutamide.
Ollie1948
in
Advanced Prostate Cancer
2 years ago
Cabazitaxel Plus Enzalutamide
There was a phase 1 and phase 2 trial that proved the safety of this combination and they also saw a PSA response 30% or more in 30% of the patients who had previously been treated with
Abiraterone
.
There was a phase 1 and phase 2 trial that proved the safety of this combination and they also saw a PSA response 30% or more in 30% of the patients who had previously been treated with
Abiraterone
.
EdBacon
in
Advanced Prostate Cancer
2 years ago
What first?: Provenge or Nubeqa?
In the post chemotherapy space, two new oral agents have gained approval,
abiraterone
acetate and enzalutamide. The agent
abiraterone
acetate is an androgen biosynthesis inhibitor and lowers testosterone and testosterone metabolite levels by impacting the binding domain of the androgen receptor.
In the post chemotherapy space, two new oral agents have gained approval,
abiraterone
acetate and enzalutamide. The agent
abiraterone
acetate is an androgen biosynthesis inhibitor and lowers testosterone and testosterone metabolite levels by impacting the binding domain of the androgen receptor.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Update liver & lymph biopsy
Abiraterone
was never prescribed yet and it is worth a try. The liver biopsy states, 'CT guided biopsy from FDG Avid left lobe liver lesion shows deposits of Adenocarcinoma.There are atypical cells noted in clusters & sheets. Cells show high N:C ratio, prominent nucleoli & clear cytoplasm.
Abiraterone
was never prescribed yet and it is worth a try. The liver biopsy states, 'CT guided biopsy from FDG Avid left lobe liver lesion shows deposits of Adenocarcinoma.There are atypical cells noted in clusters & sheets. Cells show high N:C ratio, prominent nucleoli & clear cytoplasm.
spw1
in
Advanced Prostate Cancer
2 years ago
affordable Rx medications
This one only handles certain generic drugs at present, and
Abiraterone
Acetate (generic Zytiga) is one of those in their formulary. Please post related URL links and/or email addresses where possible.
This one only handles certain generic drugs at present, and
Abiraterone
Acetate (generic Zytiga) is one of those in their formulary. Please post related URL links and/or email addresses where possible.
Shams_Vjean
in
Advanced Prostate Cancer
2 years ago
BATMAN
Post-BAT, the PSA50 and PSA90 responses to
abiraterone
or enzalutamide were 94.4% and 66.7%, respectively and median PFS was 20.6 months. Patients with peak PSA level of â„9 ng/ml after BAT had median PFS of 20.6 months versus NR for those having PSA < 9 ng/ml (HR: 0.122, p < 0.001).
Post-BAT, the PSA50 and PSA90 responses to
abiraterone
or enzalutamide were 94.4% and 66.7%, respectively and median PFS was 20.6 months. Patients with peak PSA level of â„9 ng/ml after BAT had median PFS of 20.6 months versus NR for those having PSA < 9 ng/ml (HR: 0.122, p < 0.001).
pca2004
in
Fight Prostate Cancer
2 years ago
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