Having same issues with 2-digits being ulcerated, now am having skin discoloration in hands, itching reaction which has caused bruising, weight loss, numbness in arms, hands, sweating profusely only at bedtime, sleep deprivation. Am concerned, yet there seems to be no answer why? Veins are so visible , do not have any blockages, nor masses in chest. yet this is on-going only at bedtime. Does anyone out there relate to this? I am so concerned, especially with the weight loss, all blood work and organs are stable. Hospital thinks I am a 51-50 (mentally unstable-imagining symptons ) , just for attention not true. Pain is unbearable still. Had an IV tranfusion, do not know if it worked, new stuff has occurred as I listed above. Rash on both arms after this treatment. Can anyone relate ? Thank-you.