Quality of life on Lynparza PARP inhibitor

[HopeSeeker22]

I'm a care advocate for my mother, who was diagnosed with ovarian cancer August 2022. After 6 rounds of chemo and debulking surgery, we're bring told that they recommend she go on Lynparza. Has anyone here been on it? How long and what are the side effects? We're curious about quality of life on the drug since it's something more long-term. Thank you!

[CapeCodBeachBum]

I’ve been taking Lynparza for almost 3 years for primary peritoneal cancer with a BRCA1 mutation. First 6 weeks, had mild nausea which was easily managed with compazine. After that my body adjusted. Some fatigue for a few months but nothing like I had with chemo. At this point, the only inconvenience is having labs checked frequently. I’m going every 6 weeks now but it was monthly until my most recent visit with oncologist. I expect to stay on indefinitely, Well worth the early side effects !

[HopeSeeker22 in reply to CapeCodBeachBum]

Thank you for sharing your experience, CapeCodBeachBum!

[delia2]

Hi. Lots of people are on it. It’s been a miracle drug for me. I’m somatic brca1. I went on it after chemo for first recurrence which had only partial success. Olaparib got rid of the remaining cancer. I had many side effects at first, joint pain, nausea, fatigue. After 31 months I still have fatigue. I wish I had taken it after frontline. That’s the ideal. I have been on a reduced dose the entire time.

[HopeSeeker22 in reply to delia2]

Thank you, delia2!

[Catcher910]

I’ve been on Lynparza for 4 months and have virtually no noticeable side effects.

[9667]

I was on Lynparza for 2 years and 8 months. Other than some fatigue, I did great on it!! Hoping for a LONG LIFE!! Exercise is important while on Lynparza.

[quillette]

after reading all the scary stories of lynparza and zejula i keep on wondering whats the point - the cancer i have has no germline familial connections

they sent tumour out for dna of that tumour - nothing - its not in any database

guess will b their guinea pig

not looking forward to reactions from whatever pills they choose

also in maternal line there is idiopathic tendency to blood clots