Oserdu and Increase Cholestrol

[Elle713]

I was told Oserdu can increase cholesterol. I’ve been on it two months so far and, yes, my cholesterol is high!

oncologist is encouraging getting on a statin. My MD is trying to be conservative about throwing me on a statin. Anybody had cholesterol spike with Oserdu? How did you proceed? Does it ever go down? My cancer markers are up to 61 now also. Appreciate any input on Oserdu

[KMBL_]

My cholesterol was high before going on. The second time I tested, it went to 275. I didn’t go on anything. My triglycerides were good. I was just tested again, and it’s down to 230. I don’t plan on going on a statin. I’ve been on 6.5 months. Tumor markers can raise for a few months, so try to give them a chance to drop.

[Elle713 in reply to KMBL_]

Thank you. That’s very helpful for me to know. Appreciate your reply. Have you had any side effects or any progression thus far?

[KMBL_ in reply to Elle713]

I had a lot of fatigue the first four months or so, but that’s gotten a little better. I had to take Omeprazole for a few months as well. I don’t believe I’ve had progression, as my tumor markers dropped for five months. They went up a tick this month, but I had a cold, so I’m not worried. My tumor markers are a very good indicator. My mets are in my bones, bone marrow, and stomach. If it progresses in my stomach, I start not being able to eat and lose weight. I gained weight with this.

[Elle713 in reply to KMBL_]

Sounds like you have done very well. I’m glad to hear. I know this is a fairly new treatment so there’s not alot of information. Im wondering if anyone takes less than 345mg.

Continued good luck to you.

[KMBL_ in reply to Elle713]

Thank you. I hope you do well also. There is an Orserdu Facebook group. I do some take less.

[TammyCross]

I was on Arimidex, which increases cholesterol. I had never had a problem, but it did get high. Primary doc wanted to put me on a statin, but I resisted. I went on exemestane, which is even more likely to cause high cholesterol. I got it down quite a bit with diet, but still high. I just started a low dose of a statin, finally. I have other risk factors for stroke/heart attack.

I looked up interactions, and it turns out the statin interacts with the CDK4/6 inhibitor I am taking (Kisqali). I am on a reduced dose of Kisqali because of heart issue, and the statin amplifies the Kisqali. Neither my onc or primary is concerned.

[Elle713]

Thanks Tammy. So much to juggle. Everything causes something else. And then a new drug for the something else’s side effects.