Multiple liver Mets. Treatment changed to abraxane

[Cureforever]

Hi everyone,

I wonder if anyone lives with multiple liver mets and what is the treatment. Please share. Thank you.

Best,

Marina

[Silver126]

Hi, yesterday I came to know that Xeloda stopped working. My recent PET scans showed increased activity in liver ( three mets) They suggested taxol, but on Monday I’ll get a second opinion. I’m going to a centre that offers local treatments too, a new one is based on protons.

[Cureforever in reply to Silver126]

Hi, Thank you for sharing. I got 6 Mets plus other spreads to lymph nodes. I was offered abraxane. I asked my doctor about y92. She said that it’s not in my case. Did you have liver Mets before ? How is your appetite? I got 6. I can’t eat. Nausea and loss of appetite. Please keep me posted Are you in the USA? Thank you

Best,

Marina

[Silver126 in reply to Cureforever]

Hi Marina! I was diagnosed in July 2020 with breast and lymph nodes involvement and one spine met. I was put on Ribociclib + letrozole. After about 6 months I was NED until November 2021, when two liver mets appeared. I was switched to Xeloda and in March PET scans showed good improvement. My recent scan showed what I wrote before. Blood tests show good liver levels apart alkaline phosphatase, which was in the range at the beginning and progressively rose up to 203. I feel very good and show no symptoms, I have good appetite and eat a lot… the onc always reports very good physical condition and it’s true. They are suggesting me taxol too but I want to see if I can also access local treatments and a new biopsy since bones and breast remain stable and maybe something changed in liver. I live in Turin, Italy. Do you live in the USA? Here NHS is very different, because all treatments are free, you pay only if you seek for a second opinion or or need scans in a couple of days. No insurance would pay for expensive systemic treatments such CDK 4/6 or surgery. Do you think you’ll agree with Abraxane suggestion? I’m scared of IV chemo, I’m also looking for a suitable trial at the moment.

Stay strong 💪🏻 🤗

[Cureforever in reply to Silver126]

Hi Silver, Thank you for sharing your experience. I am very scared but already agreed to abraxane, Iv chemo. I have progression in liver and lymph nodes and abdominal. I have no choice. I need an aggressive chemo. I live in US. Good luck to you.

[Thatflowerlady in reply to Silver126]

I was similar to Kim , I had less side effects other than hair loss to the IV Taxol than I did Ibrance .

[Silver126 in reply to Thatflowerlady]

Thanks for sharing. Was your hair loss severe? That’s the thing that I dread most… you may judge me vain, but it’s like losing my identity

[Thatflowerlady in reply to Silver126]

Oh no worries on the vanity with me. I am currently awaiting a treatment change now , one option is to go back on Taxol the ONLY a thing that is making me hesitate is the loosing my hair again . Yes I lost all my hair everywhere. I shaved it after 2nd treatment , I hate hair everywhere. I bought a really nice wig wore it for 1/2 hour lol , I wore thin beanie hats at home mainly to keep warm . Winter in Canada is cold . After I was done the taxol my hair grew back in . It was during the pandemic so I was not in the public much . I was on Ibrance a few years ago it damaged my hair so bad I had it cut short , it was awful . My hair has come back in much better than that . What I dislike the most with the hair loss is I look sick. Close friends often say they forget I am sick but with no hair it is a reminder .

Has your oncologist talked about a port for the IV treatment ?

[Silver126 in reply to Thatflowerlady]

News about switching from Xeloda to Taxol came two days ago. I told my onc I refused the beginning of this new treatmen. I had a second and third opinion last December in another two different cancer centers and tomorrow I’ll be in one if them. Here they suggested in case of worsening a new biopsy, genetic testing and local treatments. We’ll see.On the other side I don’t want to stay out of treatments for a long time.

We haven’t talked about a port, but I think it’ll be the best choice. And we haven’t talked about which taxol therapy (Abraxane, Paclitaxel, Taxotere?).

Sorry if my English isn’t perfect, but I hope you can understand. Greetings from Italy, today 36 C degrees in Turin, in the north - 80 km from France

Teresa

[Thatflowerlady in reply to Silver126]

Your English is very good , better than mine . LolSometimes I feel so rushed to have to make decisions.

Good luck with your appointment.

We also have a beautiful sunny day here .

Enjoy your day , I am sure it is lovely there .

Luann

[Cureforever in reply to Thatflowerlady]

Thanks for sharing. I am getting a port this week. I hate this disease, port, chemo everything. I dream about cure. Erx41 is going to trial the first quarter of 2023. ErSo may Hope we will be cured one day Best,

Marina

[Cureforever in reply to Thatflowerlady]

Hi Luann, Why are you supposed to change treatment again? I am supposed to go on Abraxane and I am very scared. Good luck

[Thatflowerlady in reply to Cureforever]

Hi Marina My last scans showed a mixed response to my treatment . I had a progression in my bones but stable and improvement in lungs and liver. I am waiting to hear what my options are and in the meantime continuing with previous treatment .

I find switching treatments very stressful unless I am feeling terrible . I am feeling good so this change is difficult. I had a radiation treatment 2 weeks ago and I will now wait for a call .

I hope your new medication is effective and easy on your body .

Luann

[Mumberly]

My MBC was discovered in June 2021 because lesions in my liver showed up in an annual scan of my kidney (not cancer related).

No symptoms, no previous cancer, no family history.

There were a number of sub-centimetre sized and three that were between 1 and 2 cm. From there we discovered the source was breast cancer (one 1cm lump), plus three lymph nodes, and three bone mets.

I started with 8 treatments of FEC chemotherapy and then moved to kisqali and letrozole in January. Not because the chemo wasn’t working, but because there are limits to how much one of the drugs can be administered.

Other than hair loss and low white blood counts, the chemo went really well. I was supposed to have 6 treatments (once every 3 weeks) and I asked for 2 more to get as much high test into me before I started the daily meds 😊

My body actually cooperated more with the chemo than it has the kisqali. Once my ALT count comes back down to normal range, I’ll be switching to palbo. It’s not that the kisqali wasn’t working either, it’s just the side effects won’t allow me to continue.

I continue to take letrozole every day.

I’m happy to answer any questions you have about either treatment plan.

Take care,

Kim

[Cureforever in reply to Mumberly]

Hi Kim. Thank you so much for sharing. I hope your treatment will work. Best,

Marina

[Cureforever in reply to Mumberly]

Thank you for your reply. What is FEC ? My doctor is putting me on abraxane every week, one week off after three weeks. Best,Marina

[Mumberly]

It’s an acronym for the three drugs used: fluorouracil, epirubicin, cyclophosphamide

K

[Cureforever in reply to Mumberly]

Thank you