Oral SERD trial - 1st result

[TammyCross]

When Ibrance and Fulvestrant stopped working -- 2 new mets, and old one avid -- I went into a clinical trial for an oral SERD (same mechanism as Fulvestrant, blocking estrogen receptors). The one I am on is put out by Zeno Pharmaceuticals; trial is called n-c5-0001. I take a daily capsule on empty stomach.

Had my first scan last week (using the new radioactive isotope special for ER+HER2-). Just got results and have not seen oncologist to get interpretation (tomorrow). It looks good. No mention of the two new mets that showed up on last scan, all old bone mets healed. Everything unremarkable -- except for one thing that I bet those two experts in this group could explain: "Minimal activity is demonstrated within subcentimeter right lower paratracheal node, SUV max 2.3 (3:70)."

That sounds pretty high? SUV 2.3? I have to look up what it was before, but I have been having something going on there for a year or more. Onocologist thought it might be an infection, but it has persisted, so apparently not.

[Justme153]

Ok Tammy if I'm reading this right it sounds to me like who ever was reading your scan assumed you and your doctor already knew about a node on the right lower paratracheal . He is telling you there is minimal activity within that node. So if this had been highly active before minimal would be good news. But I got the feeling you and your oncologist didn't know this was there so there is nothing to compare it to. Can they look back at other CT scans and see if this node was missed . Do you think this node and it's activity only showed up now because of the new radioactive isotope they used??