Which drugs work best? HELP!

[Winner123]

Hi.

My wife has TNBC, mets to lung with a growing mass.

We need to reduce the mass quickly.

Our UK team have offered;

treatment 1:

Abraxane (chemo)

Atezulizumab (immuno)

Treatment 2:

Paxlitaxel (chemo), weekly 90m2 w/c

Treatment 3

Capecitabine (oral)

1000mg / M2

pd X 14 days every 21 days

Does anyone have experience on the above? The more specific to TNBC would be better but I'd love to hear a cross section of "real world" experience with the above.

Thank you all in advance.

Leo, Susie and family. XX♥️

[ingaliga2]

I had a recurrence of breast cancer in two lymph nodes, one of which turned out to be TNBC. My onco put me on a combination of abraxane and tecentriq. After about 5 months the tumors were gone. I did suffer, and still am suffering, side effects from the immuno therapy drug - my liver numbers shot up and i have been dealing with autoimmune hepatitis for about 6 months now. It was almost managed but then I had my first covid shot and the numbers went back up. I am feeling great though. My last PET scan showed NED! I will take that any day of the week!. Blessings to you and your wife and good luck.

[Winner123 in reply to ingaliga2]

Thank you for your reply. I've heard about the auto immune issues with systemic immunotherapy. Can they sort that or will it carry on? X ❤️

[ingaliga2 in reply to Winner123]

My oncologist is still treating me for it. I remain optimistic because he is and I have complete confidence in him. He explains everything to me and gives me all the options. I am currently on prednisone and starting to taper off. My blood is tested weekly to track the numbers. I feel the treatment is working. My understanding is that this particular side effect is rare, just my luck! I plan to go back to playing tennis which my onco is encouraging me to do.

[PJBinMI]

Hi, from across the pond! I don't have TNBC myself, but have been dealing with metastatic bc for over 17 years and have learned alot, from others with mbc and from confrences. My impression is that the choices you have been offered are pretty standard and it is really impossible to know which would work best for your wife as each of us responds uniquely to treatment. I imagine that over time, she will likely receive, at a minimun, one of the first two choices and the third choice. The first two are quite similar. Response of cancer cells and side effects vary alot person to person. One of the difficulties with these decisions is that whatever you do, if it doesn't turn out well, it becomes an invitation to blame yourself for not having chosen differently. So anything you and your wife can do to tell yourself that you are doing the best you can with what you know at the time. Her breathing is critical so getting started soon is probably more important in the long run that which option is chosen. All any of us can do is make a choice, hope for the best and keep in close touch with the oncologist and team about symptoms and side effects! I can add that the first long term mbc patient that I met had lung mets. She'd been in treatment for over ten years when I met her and I sure was impressed by how well she looked and her energy level. I don't remember what her treatment was exactly. If you or your wife, or the two of you together, are offered appts with somebody for emotional support and education, do it! Even if we don't think we need it, it can be helpful, often in ways we never expected. Sometimes a word or two resonates with our experience and somehow makes it easier and more normal. I think it is wonderful that you are helping your wife like this! Give her a hug for me! Sending love and healng toughts .....