I’ve been on Ibrance, Letrozole and Xgeva combination now for 3 years. Was wondering if others have been on this regimen longer. I have bone Mets and some undetermined liver spots. I have tolerated this well but have noticed increased fatigue and joint pain. I have settled on the lowest dose of 75 mg for Ibrance due to neutropenia. Hoping to stay on this for as long as I can. God bless each of us!