Hi, it will be 5 years ago in July I received my diagnosis of metastatic breast cancer. I started out on exemastane and zometa infusions worked great for 4 years then I was put on letrozole when it stopped working. Letrozole only worked short time anyway Cancer has spread to a few spots in my spine. Dr and I are looking at my options and are leaning toward Exemastane again with Afinitor adding the Afinitor May get the exemastane to work again. My question is has anyone here been on this combination and how were side effects and outcome. Hope everyone is having a good day today.