Hard facts between 100mg and 125mg

[marianne88]

Thinking about asking dr to lower my ibrance from 125 to 100. Anyone have any hard facts on this or benefits. Thanks.

[MaryJ-S]

Hi Marianna,

I did not ask to lower ibrance since I just started but I did ask to lower my amounts for Afinitor, twice. The first month I got just about every side affect possible so he lowered it from 10mg to 7.5mg. I did well on that for about a year and then started getting side effects again and they were bad enough that I wanted to try another drug. But then the makers of Afinitor came up with a mouth rinse that seemed to help keep the mouth sores away. I was getting them in wierd places where they would be settling on a nerve in my mouth. That hurt! So I stayed on the 7.5mg regime for about 9 more months. Then I was having some more issues so he alternated my dosage to 7.5 on one day and 5mg the next day. That worked fine for almost another year until recently when I had to start the Ibrance and Letrozole this week. So far, no issues except for some fatigue. The main thing is if you can't handle the side effects I am sure your doctor may be agreeable to it or perhaps alternate the dosage. I don't know how long you have been on it but it may have a cumulative effect. Check with your doctor. Let me know what he says. Since I am knew to this drug I am trying to learn as much as possible.

Best wishes,

Mary

[Epinto]

I would be a good idea to discuss any side effects with your doctor and let he or she decide if it should be lowered.

[SusieIM in reply to Epinto]

Yeah, talking with your doc about your side effects is a good idea. I just started on Ibrance.

[Epinto]

The disease will most likely be determined by your shite blood cell count. If it goes too low, the disease most likely will be reduced. Good luck to u.

[Selmac]

I'm going to ask my Oncologist tomorrow to lower mine. I think I told you I'm in my third cycle and got very sick. I know he probably feels I need the higher dose but quality of life is important. Would you like me to tell you what he says tomorrow?

[marianne88 in reply to Selmac]

Yes please. I’m asking too

[Selmac in reply to marianne88]

Will do. Praying for you.

[BeckyHobson]

My doc lowered mine due to my crashing counts. I bet yours will too. I was worried that the lower dose wouldn’t work as hard as a lower dose but he assured me that it not the case and the lower dose will work just the same 😊. Everyone I’ve talked to has gotten there dose lowered. Some can’t handle it at all even at the 75mg

[Selmac]

Marianne

This will be long. I am recovering from a hip replacement. They wanted to do 5 radiation treatments to help with pain as ball was put on hip with cancer. The night after first treatment was when I got so sick. Oncologist said he thinks radiation may have hit my bowel and caused this. Anyway he actually then said since I have stomach problems he wanted to lower my Ibrance to 100 mg. I didn't have to ask. Got my Faslodex and Xgeva shots today.

[daf10]

One of our volunteers who has been taking Ibrance had her Ibrance dosage lowered to 75 mg due to low WBC She is doing fine

[Mimiholl]

I started ibrance 125 with letrozole in may 2017 . I developed a severe rash on stomach hands arms, and nauseous. Steroid creams didn't work, but Allegra did, and nauseous medicine. I gave up the nauseous medicine, by sitting calmly after taking, ,for about an hour till it passes. I just gave up the Allegra(24 hr kind) and so far so good. Alegra was very drying to my whole system, and I hate taking more drugs then I need to. Other than real tired in afternoon, neorapthy now also in my leg, hair thinning I'm doing good. I've had one xgeva shot 6 weeks ago and still have bruise and lump at sight. I see my oncologist every 2 months and it's scary not going every month. I feel like I'm free floating, not having confirmation from blood tests. Good health to everyone, and so great full for drs and medications.

[Lizannern]

I take Ibrance 125mg. and Letrozole 2.5mg. nausea is terrible with Ibrance but if I take

Zofra 8mg. 40 minutes before I take the Ibrance it helps and must take on a full stomach.

I had to stop Ibrance because my ANC was 0.3. Waiting a week and see if it comes up. Started on antibiotic and in 1 week more blood work and then maybe will start me back on lower dose of Ibrance.

[Scandia68]

Hi

As far as the info I have read on this it makes no difference other than reducing side effects

[Scandia68]

healthunlocked.com/share-me...

[8576]

It doesn't seem to matter what dose you are on as long as it works.

Cheers, June S.