I have been on Afinitor and Letrazole for 2 and half years. My tumor markers have been going up every month and this past month it jumped 80 points. So, my oncologist is switching me to Ibrance and Letrozole this coming Monday. I have had many chemos prior to Afinitor and wonding if there is anyone else who may be like me and found Ibrance to work for them. It seems like people who start Ibrance and only have a short amount of time do well on Afinitor and vice versa. So I am a bit nervous...