Started faslodex and ibrance

[MissyAnn68]

I was wondering if anyone else on this can tell me how long until they saw a positive result after starting this faslodex/ibrance combo?

Also would like to know if you have mets to the lungs if this worked.

Thanks!

[Bangorbea]

Hello MissyAnn. I started Ibrance and Faslodex for mets to bone and liver in Jan 2016. My tumor markers seemed to skyrocket after a liver biopsy late December 2015. It took 3 cycles of these drugs before the tumor markers dramatically dropped. Don't give up early. These drugs are the most promising for the longer term. Good luck on your journey.

[beachlover65 in reply to Bangorbea]

Hi Bangorbea! I am in the same boat as you - mets to bone and liver. I started on ibrance and faslodex in November, but my numbers keep going up. My marker went from 81 to 146. I am wondering if I should change, or stay the course. I can talk to my doctor sooner than my appointment on the 28th. I'm not sure what to do. It's just nice to be able to contact a person that is on the same journey.

[Hidden in reply to Bangorbea]

I was just put on Faslodex was already taking Ibrance. Hoping for a quick drop in markers.

[MissyAnn68 in reply to Hidden]

I posted a long, eventful year ago. I was switched from Ibrance to Kisqali and took these meds all year. I did not tolerate them well even on their lowest doses. Towards the fall of last year my Onc kept saying i was stable nothing had changed which we know is good. She also mentioned my lung met could be scar tissue now. So i had all i could take with the pills and side effects. I had CT and same. So she did a Pet Scan and it showed NO EVIDENCE OF METASTATIC disease. I quit Kisqali immediately and of course i still take Femera (letrozole). So thats where i am now.

The pills destroyed my digestive so i see a GI next week.

Hope you all are doing well.

[Rhwright12]

Hi Missyanne68!

I have MBC with mets to bone so my meds are different. But I have seen a lot of people on here that have been on Ibrance for years. I hope this will be the case for u...

Praying for some speedy positive results!

-Heather

[Mariannem]

You should see a response or stability with 3 month scans for follow up. I have mets to pleura. Capcitabine the first chemo I was on when first diagnosed worked the best. Note this is expected as this was my first chemo.

[My3girls]

I just recently started on Ibrance and Faslodex. I asked my doctor what the average rate to progression is and she told me about 2 years. I'm hoping it will be much longer, because so far the only side effects I've had are hot flashes, tiredness and of course some bruising from the injection site.

[Kjsmoose316]

I an on that combo now. I had my labs done about 3 months an had a 20 % change in levels.

This is my second bout with breast Cancer. It came back after 9 years in my lungs.

[MissyAnn68 in reply to Kjsmoose316]

This is my 4th bout with breast cancer, however between my 2nd (local recurrence) and my mets diagnosis was 12 years.

[Becca65]

My mets are to my peritonuem only and I recently (2nd cycle) started back on Ibrance ( it was effective in combo with letrozole for 14 months until my body needed a change temporarily - took Xeloda for 4 cycles) hoping to have less hair loss with faslodex/Ibrance compared to Ibrance/letrozole. Cancer marker #’s dropped after first cycle. I am hoping the ascites starts drying up and lessening soon in 3rd week if 2nd cycle. I have no quality of life with the ascites so hoping for relief soon.

[opnjim in reply to Becca65]

My wife breast cancer spread to her peritoneum with omental caking. Her oncologist will start her on Ibrance and faslodex. She was on Xeloda for 1 year and her CA27/29 tumor marker went from 190 to 49. Do you think Ibrance is more effective in treating peritoneum cancer than Xeloda?

[Hidden]

Even though this is a somewhat old post, I am adding a comment, in case folks come upon this later. I've been on Ibrance + Faslodex for 7 months. Did not see any great results/regression, but have held steady, which is a victory, in my book. Tumor markers (generally accurate, in my case) kept rising. Recent scans show modest...very modest...improvement. So it's not one of the common cases where everything improves with a new treatment, but I'll take it, for sure. My hope is that I can maintain this status for months or maybe years to come. My point is that the results might not be dramatic, but still positive in maintaining status quo...