Raloxifene (Evista)

Good afternoon ladies,

I was diagnosed with estrogen positive DCIS in September, had a lumpectomy in October and completed radiation in February. I had an appointment today with my oncologist to discuss estrogen blocking medications.

I was expecting her to recommend an aromatase inhibitor and was surprised when she said that my risk of recurrence was less than the risk of their quality of life altering side effects. Instead she wanted me to consider Tamoxifen. But tamoxifen is contraindicated for other medical issues I have.

So she is recommending Raloxifene (Evista)

It is an estrogen modulator that decreases the risk of breast cancer in postmenopausal women. It also promotes bone strength and is used to treat osteoporosis.

Is anyone familiar with or taking this med to prevent estrogen receptor positive breast cancer?

Thanks in advance for any information to help me decide if I should begin taking Raloxifene.


12 Replies

  • I am a 20 year estrogen receptor positive breast cancer survivor and have taken Evista (now the generic, raloxofene) from the beginning. At that time Tamoxifen was not indicated for pre-menopausal women.. A clinical trial studying the two drugs was ended early due to the success of the Evista.

    I had no side effects from the Evista and was pleased when a bone scan last year showed that my results were just below normal! I am still taking it.

    I don't think you would have anything to worry about by taking Evista. And now that a generic is available it is much less expensive.

    Best of luck regardless of what you decide!

  • RonnieDale, just saw your post after I wrote in. Thanks for replying :)

  • Thanks so much for your reply RonnieDale. You are the only person I know of who has taken this med. glad to hear you didn't have side effects. How many years have u been/were you on it? I'll let u know when I make my decision.


  • I've been on it for 20 years. It's the only drug I've taken, and I'm happy to say I've had no recurrence and my bones are strong.

    I hope it will do as well for you, should you decide to take it.


  • Hi haagr-- I've done a bit of digging around online, and it's been a little hard to find other women talking about their experience with this particular drug. Raloxifene, like all drugs, may have side effects (http://www.breastcancer.org/treatment/druglist/evista).

    This article by the Washington Post discusses some of the pluses and minuses to taking this drug as well: washingtonpost.com/national...

    Hope you're able to find the info you need to feel confident about whatever you end up taking!

  • Thanks Missa.


  • Hi! That was an excellent article in the Washington Post. As I said, the medication has been beneficial to me and I am still on it. Most of the side effects are manageable, but personal and family history have to be considered. In twenty years I had forgotten the risk of blood clots, fortunately I've been fine. Thanks for sharing.


  • Of course! So glad to hear you've had a good experience with it.

  • Back in 1999 a clinical trial called the Star Trial was done which tested Evista aginst Tamoxifen here are the results:

    Primary Outcome Measures:

    Incidence of invasive breast cancer; superiority of one of the therapies. [ Time Frame: Time from randomization to the occurance of invasive breast cancer. ]

    Determine which of the following is true:

    compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer;

    compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or

    the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.

  • Thank you so much daf10. I'm going to obtain and read the entire study to help decide Raloxifene is the way to go for me. Will also read the manufacturer's prescribing information for doctors that will detail side effects and considerations specific to the drug. I'll post my decision once I've made it.

    Thanks again,


  • Hi: I took Evista for more than 10 years after going through menopause. It was recommended by my breast specialist who I had been seeing yearly because of my tendency to have cysts. I just ( 2016) had my diagnosis of Invasive ductal carcinoma by this same surgeon and he suggested I stop the Evista and switched me to an aromatase inhibitor. I wonder if I would have had my breast cancer earlier if not for taking Evista. I never had a problem with the drug and so far seem to be doing fine with the aromatase inhibitor. It is a stronger anti estrogen drug as I understand it and many of my friends have suffered difficult side effects. Fingers crossed I will continue to be fine with taking it.

  • Thanks for your reply 1jet11

    I'm happy to hear from someone who took Evista. Sorry to hear that it ultimately did not prevent BC for you.

    Still on the fence about taking Evista. My oncologist clearly does not want me on an AI due to the risk vs benefits for me. Yet I have friends who didn't have a problem with their side effects.

    She calculated my risk for recurrurence at 5%. Adding Evista will bring it down to 2-3%.

    I just had a dexa scan and found that I have early osteopenia which Evista will help from progressing. I'll give my internist a call and discuss the whole picture with him. Though I love my surgeon and oncologist, I want to talk to someone who is caring for all of me, not just my breasts.

    I'll keep you posted.

    Thanks again


You may also like...