sickness

[kirks2092]

hi mum has discharged herself from hospital as they can’t find course of her horrendous sickness and stomach ache.

unfortunately we now have to accept the buprn is the course.

mum has serious ptsd from withdrawing from pramipexol and is terrified to go through that again she also has complete rls coverage on buprn.

we are going to try all the tips on here at first, taking the buprn in 4 etc

If it doesn’t work we will need to try another medication but we need something she can transfer to straight away without weaning the buprn

its been mentioned that methadone may be a suitable alternative or another opioid?

she needs something that covers rls but doesn’t cause sickness

if anyone can help i appreciate it x

[Joolsg]

What doctor prescribed Buprenorphine?.Her GP or her neurologist?Doctors SHOULD be helping your mother through this- but they are clearly struggling.

If Buprenorphine is now the prime culprit and Zofran and medical cannabis do not help- has any doctor suggested Subutex???

Subutex is Buprenorphine with naloxone. Naloxone is added to many opioids to prevent absorption in the gut which can lead to constipation.

Subutex will control your mum's RLS AND it MIGHT stop the nausea.

Here are a few research papers on Naloxone to stop nausea.

Show to your doctors and ask to try Subutex.

release.org.uk/drugs/subutex

sciencedirect.com/science/a...

pmc.ncbi.nlm.nih.gov/articl...

[kirks2092 in reply to Joolsg]

its a private consultant , her gp is unfortunately politely putting it useless

thanks so much i will show her this x

[davchar23 in reply to kirks2092]

Dear kirks2092,

I am sorry to hear that things haven't improved,

I have to tell you that my efforts to find "something" that even eased the nausea caused by bupre proved useless despite many many suggestions and medications that people on this sight had used and believed worked for them. For me none of the GP prescribed antinausea medications worked nor did the OTC medicines or those such as cannabis, ginger, and many others kindly put forward by members of this forum

Most GPs are ignorant on the topic of RLS and tend to put their "heads in the sand". I was lucky with a younger GP who was prepared to work with me. We both agreed that bupre was causing my nausea and you have to be sure that is the case with your Mum? If it is then my (and my GP) research and that of a fellow contributor to this site, Twicher707 in USA, should be tried.

Nausea is caused by bupre when the level in the blood exceeds a certain concentration and so it is important that the bupre concentration is steady and below the concentration (will probably vary according to the person) that causes nausea. Lets call it the "nausea % " The use of only tablets is most likely to cause the nausea % to be exceeded if the smallest ( I think that is 200mcg) tablet is taken whole. It seems that when a 200mcg tablet is taken that after about an hour the amount of bupre released is high enough to exceed the nausea %.

Therefore it is important to have a steady "background" concentration of bupre that a patch can provide. Of course that size of the patch must also be below (but as near as possible) to the nausea % line. I believe the smallest in UK (I use it) is 10mcg/hr or 0.24mg per day.. If this is not on its own enough to block RLS (try it) then small portions of tablet (start at 50mcg late in the evening) will be needed. Remember that the "weekly" patch only last 5 or 6 days and that a freshly applied patch needs at least 12-18 hours to reach it stated dose and so the patches need to be overlapped in application

I hope this helps but would appreciate you posting the outcome please.

Kind regards

Davchar

[kirks2092 in reply to davchar23]

thank you so much davchar for this

mum doesn’t have access to patches at the minute, we are going to try splitting the pill dosage

i will keep you updated