chronic depression

[kirks2092]

hi can anyone advise anti depressants that can be taken alongside buprenorphine, that also help for sleep that can help with chronic depression possibly caused by daws that won’t cause rls ?

thank you x

[SueJohnson]

trazodone

[kirks2092 in reply to SueJohnson]

thanks, sorry should have mentioned tried this but caused nausea unfortunately

[SueJohnson in reply to kirks2092]

Vortioxetine however it is on RLS-UK's not safe for RLS yet some find it is OK and also the buprenorphine might override it if it would otherwise make RLS worse.

[teakabeagle in reply to SueJohnson]

Taking Trazadone and Buprenorphine increases risk of Seratonin Syndrome

[SueJohnson in reply to teakabeagle]

Thank you. I have made a note of that. Unfortunately that also applies to methadone and tramadol.

[Hectorsmum2]

I take a supplement called 5htp its the best antidepressant i have ever used and I have been on a few. It doesnt seem to affect my restless legs but sue might know if it can make thinsg worse in some people.

[Nelsonmonths in reply to Hectorsmum2]

To help for sleeping I can recommend Tryptophan instead of 5htp. But both work way weaker than trazodone. You can try it but should consider Wellbutrin as antidepressant during the day.

[Eryl]

Could she be suffering neuro inflammation which is causing the RLS and the depression? This inframmation can be caused by food (google 'foods that cause inflammation'). youtu.be/w76HgPmnwhU?si=cIv...(Not working as expected?)

[kirks2092]

thank you everyone, have been recommended pregabalin low dose

does anyone have any experience of this?

[Trish8433]

I have suffered severe depression for years as a result of rls.I have tried all types of antidepressants with some working for a short while.

Interestingly, since I have been on Buprenorphine (0.6), for the past six months, my depression has lifted and I finally feel normal after many many years and many many different medications - special thanks to Sue and Jools and this wonder site.

[kirks2092 in reply to Trish8433]

thats great, unfortunately its caused chronic depression in my mum

i’m glad it is working for you x

[restlessstoz]

Hi, I am on venlafaxine and with buprenorphine have no symptoms of either RLS or depression which I had before starting on the anti-depressant. I'm on 75mg.

I hope you can find something that works and doesn't cause symptoms. In my expereince, once the RLS are controlled effectively by a medication, there can be a lot more leeway with what other medication can be taken. However, like all things RLS connected, every person is different. Good luck.