academic.oup.com/sleep/adva...
This study shows a reduction in serum a syn levels in RLS patients and suggests that it may be the reason for reduced dopamine/faulty dopamine system in RLS patients.
It also mentions that a high percentage are experiencing augmentation.
What a surprise!
Very interesting and what a surprise about augmentation !
And still nearly every UK neurologist is dishing out dopamine agonists and trying to convince patients that augmentation is unlikely to happen. It really defies rational belief.
interesting. Thanks Joolsg 👍
Interesting. The link only gives access to the summary (?). I’ll try to get the full paper later, as I am curious about why they looked at alpha-synuclein and what its usual function is. It would be interesting if it could be used as a biomarker, but as that isn’t mentioned in the summary, I guess not.
This is what I was wondering too. If you get a hold of the full paper let us know.
I will. Remind me if I forget.
Ha! I'll do my best! Think we'll have to remind each other to remind each other! ; )
Can't see full paper but wondering if these people had PD or not. In this paper they mention REM sleep disorders also having abnormal α-synuclein:
Thanks for posting Joolsg -another piece for the puzzle, very interesting
who wants to see links to "spinal cord excitability" in people with RLS?? :) putting it here instead of in the 48 responses on "Dopamine"
THE EXPERT PATIENT IN RLS
And now for the good news
The link between Iron and RLS
