Acetyl DL Leucine

[MrCrow]

Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports:

nature.com/articles/s41467-....

In 2020, we treated a PD patient, who also suffered from Restless Legs Syndrome (RLS) and the phenotype RBD, with the modified amino acid acetyl-D-leucine (ADLL; 5 g/day orally). Within 2 weeks after initiating ADLL treatment, the patient’s RLS symptoms had substantially abated

[SueJohnson]

Interesting although only 1 patient had RLS. It would be great to have a larger study.

[MrCrow in reply to SueJohnson]

it's OTC? where can you buy it?

[SueJohnson in reply to MrCrow]

My mistake! In investigating further it is not OTC. I will correct my previous post.

[MrCrow in reply to SueJohnson]

((((((((((((((((

[DicCarlson]

it is sold OTC in France for treatment of Vertigo. This is fascinating stuff! It is not just Leucine but acetylation changes Leucine's (an amino acid) activity...

nature.com/articles/s41598-...

[MrCrow in reply to DicCarlson]

Is N-Acetyl Leucine the same thing as Acetyl DL Leucine?

[DicCarlson in reply to MrCrow]

I believe it is the same formulation. D and L versions are usually the mirror images of the same molecule. N-acetyl-d,l-leucine is approved in France for vertigo and its l-enantiomer is being developed as a drug for rare and common neurological disorders. This is pretty much complex biochemistry basically using the acetylation to enhance absorption of leucine into organs and cells.