Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports:
In 2020, we treated a PD patient, who also suffered from Restless Legs Syndrome (RLS) and the phenotype RBD, with the modified amino acid acetyl-D-leucine (ADLL; 5 g/day orally). Within 2 weeks after initiating ADLL treatment, the patient’s RLS symptoms had substantially abated
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MrCrow
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it is sold OTC in France for treatment of Vertigo. This is fascinating stuff! It is not just Leucine but acetylation changes Leucine's (an amino acid) activity...
I believe it is the same formulation. D and L versions are usually the mirror images of the same molecule. N-acetyl-d,l-leucine is approved in France for vertigo and its l-enantiomer is being developed as a drug for rare and common neurological disorders. This is pretty much complex biochemistry basically using the acetylation to enhance absorption of leucine into organs and cells.
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