Side Effects - Ropinirole & Pramipexole

[PaddyMac1]

Hi all,

I found that the generic Ropinirole gave me nausea but the commercial ReQuip didn't, now ReQuip is being manufactured under license for GSK and the "commercial" ReQuip is giving me nausea.

I have thus switched to Pramipexole and I am currently 3 days into GLEPARK generic version, it is giving me the very same nausea.

Has anyone got any similar experiences or suggestions ?

[SueJohnson]

Welcome to the forum. You will find lots of help, support and understanding here. See my reply to Help1963. Since you are having nausea it is best to come off it. Ropinirole, requip and pramipexole are no longer the first-line treatment for RLS, gabapentin or pregabalin is. It used to be the first-line treatment which is why so many doctors prescribed it but they are not uptodate on the current treatment recommendations. Besides up to 70% of people will eventually suffer augmentation according to the Mayo Clinic Updated Algorithm on RLS which believe me you don't want because it can be hell to come off it and the longer you are on it, the harder it will be to come off it and the more likely your dopamine receptors will be damaged so that the now first line treatment for RLS gabapentin won't work. Check out the Mayo Clinic Updated Algorithm on RLS which discusses augmentation and the latest guidelines on RLS treatment and refer your doctor to it as many doctors do not know much about RLS or are not uptodate on it as yours obviously isn't or s/he would never have prescribed a dopamine agonist . Https://mayoclinicproceedings.org/a...

[PaddyMac1 in reply to SueJohnson]

Thanks Sue,

The original ReQuip worked well for me but the idea of damaging receptors and augmentation is very worrying.

Is Pregabalin as effective as Dopamine Agonists?

[SueJohnson in reply to PaddyMac1]

Yes unless your dopamine receptors have been damaged by being on DAs for + or - 10 years. Then you need to go on low dose opioids.