Has anyone took endep to wean them selves off pramipexole. I was prescribed it yesterday cause l have Augmented from been on Pramipexole 0.125 for 3 years February next month. I missed it tonight cause l havent been sleeping. So l can at least see if l sleep Thursday night Aust time. Its been a hell tonight "Wed" into "Thur" morning just wishing l could sleep.
The Endep 10mg is the same as Amitriptyline. My brother takes it for sleep and said it helps him. Is a antidepressant.
I read that it can give low pulse reading. Mine already sits around 52 down to 42 lying in bed.lts 49 just now.
Cause l get anxiety l get worried trying new drugs.
It was a nightmare when l first took Pramipexole.
I have taken it yet.
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Boss15
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Endep is Amitriptyline and makes RLS 1000% worse for 99% of people. Avoid. If you’ve just started- stop instantly.
Diazepam or clonazepam would be much better or pregabalin.
All help anxiety and RLS.
You need strong painkillers to wean off pramipexole- usually an opioid like tramadol or OxyContin. Even then, withdrawal is very hard but definitely worth it. Once off pramipexole, pregabalin works very well for most people to control symptoms.
Read the pinned post on augmentation and don’t let them give you another DA like Ropinirole or the Neupro patch as you will augment again.
Get your serum ferritin checked- ensure it’s above 100. That will help alleviate augmentation and sometimes relieves RLS for 50% of sufferers.
Ok- the serum ferritin is almost at the acceptable level but the serum iron should be above 60. According to the US experts, for RLS patients, serum iron should be greater than 60, per cent iron saturation should be greater than 16%, TIBC (Total Iron Binding Capacity) should be less than 400 and serum ferritin should be greater than 100. In fact, the new recommended ferritin number for RLS patients is at least 100.
So all your levels are good apart from iron and ferritin.
Take ferrous bisglycinate every other night.
That will help long term but you still need to get off pramipexole. Reduce very, very slowly and ask your doctor for smaller doses as I know it's difficult to cut those pills in half or in quarter.
There are many of us who have gone through withdrawal and nearly everyone has a really rough time but we are all glad we managed to get off Dopamine Agonists. The daytime RLS disappears and the severity and intensity diminishes.
Many have to take other meds ( but some lucky people manage to resolve RLS by raising iron, taking magnesium and eliminating triggers from their diet.
I wish you strength.
Holler if you need advice during withdrawal- there'll be someone on here (at most times) who has been through it, but bear in mind it's a UK site so we are 12 hours behind Australia.
Lyrica ( pregabalin) has side effects- dizziness, weight gain, water retention but it’s different for everyone.
It’s now the preferred choice for RLS and the majority do well on it.
It’s not as likely to cause augmentation as dopamine agonists ( there was a US study that showed it caused augmentation in a small number of patients).
I had side effects for the first 3 months but they settled/ disappeared.
Increase the dose slowly ( 25mg every 3 days) and work up to the maximum dose of 300mg. Most do well on smaller doses of around 150 mg so see how that works.
It is fully effective after 3 weeks and is best taken at night.
Avoid magnesium 3 hours before or after pregabalin as it reduces effectiveness.
Most people find it doesn’t help until withdrawal symptoms from dopamine agonists have settled.
I am not familiar with Australian Iron panel numbers but be aware that all countries will tell you iron levels are normal within their ‘set’ levels but for RLS the numbers have to be much higher. Doctors and neurologists who do not have expertise in RLS are unaware of this.
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