I am seeing a naturopath for my RLS and insomnia. I was prescribed Taurine, 1000 mg, and after two weeks am sleeping 7 hours a night. Hope it keeps working, as it has been years since I had this much sleep a night.
Taurine : I am seeing a naturopath for... - Restless Legs Syn...
As ever, if it works for you and does no harm then do it.
I read that Taurine is a "non essential" amino acid and the body can manufacture it's own given sufficient protein in the diet.
I also read that it can be used for "lack of sleep", i.e. usually in conjunction with caffeine to counteract sleepiness caused by lack of sleep.
I'm not sure then, how a stimulant can help you sleep.
Maybe you have misunderstood the naturopaths reason for prescribing it.
Here are some papers for you to peruse, Manerva.
All very interesting. It would appear that Taurine is anything but non-essential. At the very least it appears brain-protective, and particularly DA receptor protective, which, God knows, we need.
Who knew - certainly not our doctors.
If you google 'taurine and dopamine you will find a lot more .......
Thanks, I 'll look at these. I can be persuaded by good evidence.
Taurine is NOT an "essential" amino acid in respect of it's not one of the 9 amino acids which CANNOT be synthesised in the body. The 9 "essential" amino acids MUST be present in the diet.
Taurine does appear to be something that is "necessary" to sustain life, so might be better called "vital", but it CAN be synthesised in the body so is not essential in the diet.
article one - suggests that taurine can protect the brain from the dopaminergic neurodgeneration found in Parkinson's disease. (No comment on the paraquat poisoning). Although, dopaminergic dysfunction is associated with RLS, there is no conclusive evidence that RLS is a degenerative condition, at least 12 years ago!
There is limited evidence of a causal connection between RLS and PD at least in 2018
I couldn't access the second article, link didn't work (I hope "inhuman experiment didn't meant that paraquat was used on humans!)
CONCLUSION - RLS may or may not cause PD (Oh sh**!)
Tons of evidence on the benefits of sufficient taurine for various issues including PD. Nothing specific for RLS.
My hippocampal aging means that my memory of the formal logic I learned in the early 1970's partly now escapes me, but I do remember something about partial premises do not support absolute conclusions.
i.e. some things work for some people with RLS, but not all things work for all people.
Ooh , it helps the ageing hippocampus. That I certainly need. My hippocampus has gone on strike.
I see, I was wondering, there's a few words starting in "hippo"
Hippodrone a large flying animal with four propellers
Hippocrates - a man named because of his obsession with large wooden boxes
Hippocratic oath - a swear word uttered by the same man when a box fell on him.
Hippopotamus - I believe this is an abbreviation of "Hippo pot of mustard", a big jar of condiment.
I hear it can be dangerous living in Africa.
The neurotransmitters Glutamate (excitable - keeps you awake) and GABA (relaxing) are significant players in sleep regulation. "Taurine is a sulfur containing amino acid structurally similar to the neurotransmitters glycine and GABA (Gamma aminobutyric acid). It is the most abundant free amino acid in retina and the second most abundant free amino acid in the central brain after glutamate" ncbi.nlm.nih.gov/pmc/articl...
I take a 1/2 dose of ibuprofen when I wake in the night. It blocks glutamate. I have recently also started CoQ10 and Ginko at night both supposedly block glutamate and promote GABA.
More on Taurine by Cynthia Perkins...
"The amino acid taurine increases the GAD enzyme and consequently GABA levels. Additionally, taurine doubles as an inhibitory neurotransmitter and can bind directly to GABA receptors, so it can help provide balance naturally in that manner as well."
An interesting read, is this evidence for the use of Taurine to promote sleep?
GABA is inhibitory (calming), Glutamate is excitatory.
GABA and Glutamate Balance - When GABA is low, glutamate is high and vice versa. So in order to increase (GABA), it’s not simply a matter of bringing it up, you must also focus on reducing the excess glutamate.
So GABA - up, Glutamate - down.
The amino acid taurine increases the GAD enzyme and consequently GABA levels. Additionally, taurine doubles as an inhibitory neurotransmitter and can bind directly to GABA receptors,
If taurine is deficient, then the GAD enzyme may be low as well, therefore, supplementing with taurine can be used to manage the GABA and glutamate balance
However, there are a couple of gene mutations that can result in negative effects from taurine supplementation
Taurine supplementation may increase glutamate in some people.
The rest got so complicated that I lost the will to carry on.
This seems to be another example, see the post on Potassium Citrate, where because some people with a specific deficiency might find relief from RLS from a supplement, that everybody with RLS will irrespective of any deficit will benefit. It appears that for some, taurine might do more harm than good.
I suppose it is a matter of personal preference, but I'm not going to start eating meat again after 45 years and I find the statement that most people don't eat enough fat difficult to swallow!
It's a shame that everybody can't be genetically tested at birth and given magic gene changing pills as appropriate.
To sleep (if you can), perchance to dream.
The Glutamate excess is the reason that I could get 2-3 hours of sleep and of course be tired but not sleepy all day. The ibuprofen connection is interesting. Before I had RLS in June of 2016 - I had sleep issues the Fall of 2015 into 2016 (and still have BTW), and discovered that taking an ibuprofen initiated a back to sleep advantage. The sleep issues perplexed me - I covered my electric meter, turned off wifi at night - no help.
Caffeine has opposite effects where RLS is concerned- for some it's a stimulant, for some it helps RLS in the night. So taurine provides balance. Certainly think it's worth a shot! Swanson's sells quite a few different brands online, all pretty reasonable. And it's interesting that naturopathy has an approach here.
I’ve tried taking some taurine, I only took 500mg and it does seem to be helping. Difficult to say at this early stage as sometimes I do get a couple of nights remission, but, fingers crossed the past two nights I have slept well. I have read that it helps it to work better if taken with zinc so might try that as well. Thanks Sarasota16.