I have been on Cymbalta for 10 years. I started getting RLS soon after starting the Cymbalta, but I only got it occasionally. Now, having been on it for so long I began to suffer with RLS every night . Originally I felt the very nerve racking sensations in my legs. Gradually I not only suffered with RLS at night but also during the day. It was a terrible feeling like being trapped in a very painful body and having no way to stop the pain except to walk and walk and walk- something very hard to do when you are exhausted because RLS prevents me from being able to sleep! My neurologist prescribed Mirapex, which brought relief for a while until he increased the dose to such a high level that I went into what is called AUGMENTATION- which means that now the Mirapex BROUGHT ON THE RLS. Imagine that!! So he switched me over to Requip, but gradually increased the dose so once again I went into AUGMENTATION. I felt like I was going to lose my mind. My legs were driving me nuts all day long, soon i got RLS in my arms and living did not seem so worthwhile anymore to be honest. Well, then my neurologist said that I would have to be on Percocet which is an OPIOD. I had a 5mg tablet from a previous prescription from this same doctor, but when I said that the Percocet made me feel dizzy and just awful in general, he told me to split it in half. I asked my pharmacist about this and was told that was a very dangerous to split Percocet because the broken tablet would get into my bloodstream too fast and actually could cause- now get this- DEATH! Needless to say this neurologist is now history for me. But luckily my friend did some research and discovered that Cymbalta can bring on RLS. So I took myself off it and 2 days later NO MORE RESTLESS LEGS- A MIRACLE RIGHT. HOWEVER, WHY IS IT THAT NO DOCTOR OR PHARMACIST EVER TOLD ME ABOUT THE CYMBALTA -RLS CONNECTION!!!!!!!!!!! I AM LIVID!! I SUFFERED FOR SO LONG, THEY KNEW I WAS SUFFERING AND NO PROFESSIONAL, YES NO PROFESSIONAL EVER MENTIONED THE CONNECTION. I AM NOW FREE OF RLS AND ACTUALLY CAN SLEEP AT NIGHT. I HOPE ALL OF YOU OUT THERE WHO HAVE BEEN ON CYMBALTA WILL HAVE THE SAME RESULTS WHEN YOU EXPERIMENT BY GETTING OFF CYMBALTA. MY BEST WISHES TO YOU ALL!!!!!!!!!!!!!!!!!!!!!!!!!!!! (sometimes you will have to be your own doctor, even though doctors just hate it when you read to education yourself about your ailment- come to think of it, isn't there a book out there titled DOCTORS CAN KILL YOU!!